Ageing, but not yet senescent, rats exhibit reduced muscle quality and sarcoplasmic reticulum function: Age and muscle quality
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AIM: Reduced muscle force greater than expected from loss of muscle mass has been reported in ageing muscles. Impaired sarcoplasmic reticulum (SR) Ca(2+) release has been implicated as a possible mechanism, and attributed to several factors, including loss of ryanodine receptor (RYR) expression and protein binding. The aim of this study was to evaluate muscle quality and SR Ca(2+) release in ageing rats that were not so old that major atrophy had occurred. METHODS: We collected in situ force data from the plantarflexor muscle group and muscle mass from the constituent muscles to determine muscle quality (force/mass) in adult (6-8 months) and ageing (24 months) rats (n=8/group). We evaluated SR Ca(2+) uptake and release, and determined expression of key proteins associated with Ca(2+) release [RYR and FK506 binding protein (FKBP)] and uptake (SERCA, parvalbumin, calsequestrin). RESULTS: Plantarflexor force and muscle quality were reduced with ageing (approx. 28 and 34%, respectively), but atrophy was limited, and significant only in the medial gastrocnemius (approx. 15%). The fast phase of SR Ca(2+) release was reduced with ageing in both gastrocnemii, as was FKBP expression and FKBP-RYR binding, but RYR expression was not affected. Similar, but non-significant changes were present in the plantaris, but the soleus muscle generally showed no ageing-related changes. CONCLUSION: These data suggest a possible role for impaired SR Ca(2+) release in ageing-related loss of muscle quality, although not through loss of RYR expression.
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Loss of muscle performance has a greater negative impact on older adults than loss of muscle mass.
“the preponderance of evidence from years indicates that loss of muscle performance has a greater negative impact on older adults than loss of mass [18, 20–25, 37–39].”
From Targeting Intramyocellular Lipids to Improve Aging Muscle Function (2025) · cites this paper as [25]
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- Ó 2010 The Authors Acta Physiologica Ó 2010 Scandinavian Physiological Society, doi: 10.1111/j.1748-1716.2010.02191.x Age and muscle quality Æ D W Russ et al. Acta Physiol 2011, 201, 391-403 17481716, 2011, 3, Downloaded from https://onlinelibrary.wiley.com/doi/10.1111/j.1748-1716.2010.02191.x by Mount Vernon Nazarene University, Wiley Online Library on [14/01/2026]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License · DOI
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Self-citationTargeting Intramyocellular Lipids to Improve Aging Muscle Function
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“Regardless of the term used, the preponderance of evidence from years indicates that loss of muscle performance has a greater negative impact on older adults than loss of mass [18, 20–25 , 37– 39].”
Self-citation
- Authors
- Russ, D. W., Grandy, J. S., Toma, K., & Ward, C. W.
- Affiliations
- Ohio University (US)
- University of Maryland, Baltimore (US)
- Corresponding author
- Russ, D. W.
- Venue
- Acta Physiologica
- Publisher
- Wiley
- Published
- 2010-11-09
- Volume
- 201
- Issue
- 3
- Pages
- 391-403
- ISSN
- 1748-1708 (ISSN-L)
- OpenAlex
- W1880253657
- Cited by
- 61
- References
- 68
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 6 · 2012: 10
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Acta Physiologica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R03AR053318)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- muscle aging, muscle quality, sarcoplasmic reticulum, ryanodine receptor, FKBP, SERCA, calsequestrin, parvalbumin, muscle force, muscle atrophy, plantar flexor muscles, gastrocnemius, soleus muscle, rats
- MeSH terms
- Aging, Animals, Male, Muscle Contraction, Rats, Inbred F344, Sarcoplasmic Reticulum, Muscle, Skeletal, Ryanodine Receptor Calcium Release Channel, Calcium Signaling, Rats, Muscle Strength
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