Cited by 278Algal biology and biofuel productionFatty Acid Research and HealthMicrobial Metabolic Engineering and Bioproduction

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Biotechnological production and applications of the ω-3 polyunsaturated fatty acid docosahexaenoic acid

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Sijtsma, L., de Swaaf, M. E.·2004·Applied Microbiology and Biotechnology

DOI 10.1007/s00253-003-1525-y

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Abstract

Docosahexaenoic acid (DHA) is a polyunsaturated fatty acid composed of 22 carbon atoms and six double bonds. Because the first double bond, as counted from the methyl terminus, is at position three, DHA belongs to the so-called omega-3 group. In recent years, DHA has attracted much attention because of its beneficial effect on human health. At present, fish oil is the major source of DHA, but alternatively it may be produced by use of microorganisms. Marine microorganisms may contain large quantities of DHA and are considered a potential source of this important fatty acid. Some of these organisms can be grown heterotrophically on organic substrates without light. These processes can be well controlled and DHA with constant quality can be produced all year round. This paper reviews recent advances in the biotechnological production of DHA by marine microorganisms.

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Authors: Sijtsma, L., & de Swaaf, M. E.
Affiliations: Wageningen University & Research (NL)
Corresponding author: Sijtsma, L.
ORCID: Sijtsma, L.
Venue: Applied Microbiology and Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2004-01-22
Volume: 64
Issue: 2
Pages: 146-153
ISSN: 0175-7598 (ISSN-L)
1432-0614
DOI: 10.1007/s00253-003-1525-y
OpenAlex: W2093047642
Cited by: 278
References: 60
Citations by year: 2026: 1 · 2025: 9 · 2024: 8 · 2023: 7 · 2022: 9 · 2021: 18 · 2020: 19 · 2019: 15 · 2018: 14 · 2017: 15 · 2016: 9 · 2015: 22 · 2014: 22 · 2013: 20 · 2012: 20
FWCI: 6.52
Type: journal article
Language: en
Open access: green
research.wur.nl
Licence: www.springer.com/tdm (tdm)
Locations: Applied Microbiology and Biotechnology (publishedVersion)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Keywords: docosahexaenoic acid, omega-3 fatty acids, polyunsaturated fatty acids, marine microorganisms, heterotrophic cultivation, fish oil alternatives
MeSH terms: Animals, Biotechnology, Dinoflagellida, Docosahexaenoic Acids, Fungi, Bioreactors, Eukaryota

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Biotechnological production and applications of the ω-3 polyunsaturated fatty acid docosahexaenoic acid

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