The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Lactic acid bacteria producing B-group vitamins: a great potential for functional cereals products
Abstract
Wheat contains various essential nutrients including the B group of vitamins. However, B group vitamins, normally present in cereals-derived products, are easily removed or destroyed during milling, food processing or cooking. Lactic acid bacteria (LAB) are widely used as starter cultures for the fermentation of a large variety of foods and can improve the safety, shelf life, nutritional value, flavor and overall quality of the fermented products. In this regard, the identification and application of strains delivering health-promoting compounds is a fascinating field. Besides their key role in food fermentations, several LAB found in the gastrointestinal tract of humans and animals are commercially used as probiotics and possess generally recognized as safe status. LAB are usually auxotrophic for several vitamins although certain strains of LAB have the capability to synthesize water-soluble vitamins such as those included in the B group. In recent years, a number of biotechnological processes have been explored to perform a more economical and sustainable vitamin production than that obtained via chemical synthesis. This review article will briefly report the current knowledge on lactic acid bacteria synthesis of vitamins B2, B11 and B12 and the potential strategies to increase B-group vitamin content in cereals-based products, where vitamins-producing LAB have been leading to the elaboration of novel fermented functional foods. In addition, the use of genetic strategies to increase vitamin production or to create novel vitamin-producing strains will be also discussed.
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“Vitamin production by LAB varies considerably, being a species-specific or strain-dependent trait. Hence, the genetic information for riboflavin biosynthesis is species and/or strain-specific traits in LAB [64].”
From Genomic Characterization of Lactiplantibacillus plantarum Strains: Potential Probiotics from Ethiopian Traditional Fermented Cottage Cheese (2024) · cites this paper as [64]
Citations
Cites
Institute of Medicine (1998) · National Academies Press eBooks · doi:10.17226/6015 · Cited by 2,464
Complete genome sequence of Lactobacillus plantarum WCFS1
Kleerebezem, M., Boekhorst, J., van Kranenburg, R., Molenaar, D., Kuipers, O. P., Leer, R., Tarchini, R., Peters, S. A., Sandbrink, H. M., Fiers, M. W. E. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337704100 · Cited by 1,472
Riboflavin (vitamin B-2) and health
Powers, H. J. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.6.1352 · Cited by 1,030
The Chemical and Biological Versatility of Riboflavin
Massey, V. (2000) · Biochemical Society Transactions · doi:10.1042/bst0280283 · Cited by 713
Folate Production by Probiotic Bacteria
Rossi, M., Amaretti, A., & Raimondi, S. (2011) · Nutrients · doi:10.3390/nu3010118 · Cited by 683
Machlin, L. J. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90176-4 · Cited by 633
LeBlanc, J. G., Laiño, J. E., del Valle, M. J., Vannini, V., van Sinderen, D., Taranto, M. P., de Valdez, G. F., de Giori, G. S., & Sesma, F. (2011) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2011.05157.x · Cited by 529
Vitamin B 12 Sources and Bioavailability
Watanabe, F. (2007) · Experimental Biology and Medicine · doi:10.3181/0703-mr-67 · Cited by 519
Fermented functional foods based on probiotics and their biogenic metabolites.
Stanton, C., Ross, R., Fitzgerald, G., & van Sinderen, D. (2005) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2005.02.008 · Cited by 497
Comparative Genomics of the Vitamin B12 Metabolism and Regulation in Prokaryotes
Rodionov, D. A., Vitreschak, A. G., Mironov, A. A., & Gelfand, M. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305837200 · Cited by 472
Research works printed but not linked: 5
- Food and Drug Administration (1996) Food standards: amendment of standards of identity for enriched grain products to require addition of folic acid. Fed Regist 61:8781–8807
- Kumar S, Ghosh K, Das KC (1989) Serum B12 levels in an Indian population: an evaluation of three assay methods. Med Lab Sci 46:120–126
- LeBlanc JG, Savoy de Giori G, Smid EJ, Hugenholtz J, Sesma F (2007) Folate production by lactic acid bacteria and other food-grade microorganisms. In: Méndez-Vilas A (ed) Communicating current research and educational topics and trends in applied microbiology. Formatex Research Center, Badajoz, pp 329–339
- Rivlin RS, Pinto JT (2001) Riboflavin (vitamin B2). In: Rucker RB, Suttie JW, McCormick DB, Machlin LJ (eds) Handbook of vitamins, 3rd edn. Marcel Dekker Inc, New York, pp 255–275
- Tanphaichitr V (2001) Thiamine. In: Rucker RB, Suttie JW, McCormick DB, Machlin LJ (eds) Handbook of vitamins, 3rd edn. Marcel Dekker Inc., New York, pp 275–310
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Metabolism Characteristics of Lactic Acid Bacteria and the Expanding Applications in Food Industry
Wang, Y., Wu, J., Lv, M., Shao, Z., Hungwe, M., Wang, J., Bai, X., Xie, J., Wang, Y., & Geng, W. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.612285 · Cited by 1,001
LeBlanc, J. G., Chain, F., Martín, R., Bermúdez‐Humarán, L. G., Courau, S., & Langella, P. (2017) · Microbial Cell Factories · doi:10.1186/s12934-017-0691-z · Cited by 912
Health benefits of fermented foods
Şanlier, N., Gökcen, B. B., & Sezgin, A. C. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1383355 · Cited by 789
Septembre‐Malaterre, A., Remize, F., & Poucheret, P. (2017) · Food Research International · doi:10.1016/j.foodres.2017.09.031 · Cited by 657
Health Benefits of Lactic Acid Bacteria (LAB) Fermentates
Mathur, H., Beresford, T. P. J., & Cotter, P. D. (2020) · Nutrients · doi:10.3390/nu12061679 · Cited by 394
Metadata
- Authors
- Capozzi, V., Russo, P., Dueñas, M. T., López, P., & Spano, G.
- Affiliations
- University of Foggia (IT)
- University of the Basque Country (ES)
- Centro de Investigaciones Biológicas Margarita Salas (ES)
- Corresponding author
- Spano, Giuseppe
- Venue
- Applied Microbiology and Biotechnology
- Published
- 2012-10-24
- Volume
- 96
- Issue
- 6
- Pages
- 1383-1394
- ISSN
- 0175-7598 (ISSN-L)
- 1432-0614
- OpenAlex
- W2000886831
- Cited by
- 290
- References
- 78
- Citations by year
- 2026: 15 · 2025: 25 · 2024: 24 · 2023: 24 · 2022: 27 · 2021: 30 · 2020: 25 · 2019: 22 · 2018: 16 · 2017: 32 · 2016: 15 · 2015: 14 · 2014: 16 · 2013: 3
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Applied Microbiology and Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Health Sciences › Nursing › Nutrition and Dietetics › Folate and B Vitamins Research
- Keywords
- lactic acid bacteria, B vitamins, riboflavin, vitamin B11, vitamin B12, vitamin biosynthesis, wheat, fermented foods, probiotics, auxotrophy
- MeSH terms
- Bacteria, Edible Grain, Food Handling, Vitamin B Complex, Lactic Acid, Functional Food
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