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Cited by 60Fungal and yeast genetics researchAntifungal resistance and susceptibilityYeasts and Rust Fungi Studies

Rapid and extensive karyotype diversification in haploid clinical Candida auris isolates

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Bravo Ruiz, Gustavo, Ross, Zoe K., Holmes, Eilidh, Schelenz, Silke, Gow, Neil A. R., Lorenz, Alexander·2019·Current Genetics
DOI 10.1007/s00294-019-00976-wPMC PMC6744574

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Abstract

Candida auris is a newly emerged pathogenic microbe, having been identified as a medically relevant fungus as recently as 2009. It is one of the most drug-resistant yeast species known to date and its emergence and population structure are unusual. Because of its recent emergence, we are largely ignorant about fundamental aspects of its general biology, life cycle, and population dynamics. Here, we report the karyotype variability of 26 C. auris strains representing the four main clades. We demonstrate that all strains are haploid and have a highly plastic karyotype containing five to seven chromosomes, which can undergo marked alterations within a short time frame when the fungus is put under genotoxic, heat, or osmotic stress. No simple correlation was found between karyotype pattern, drug resistance, and clade affiliation indicating that karyotype heterogeneity is rapidly evolving. As with other Candida species, these marked karyotype differences between isolates are likely to have an important impact on pathogenic traits of C. auris.

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  • The karyotypic plasticity displayed by C. auris in response to stressors may contribute to this organism's ability to adapt and persist in the skin niche.

    “In addition, the karyotypic plasticity displayed by C. auris in response to stressors may contribute to this organism’s ability to adapt and persist in the skin niche (23).”

    From Candida auris Forms High-Burden Biofilms in Skin Niche Conditions and on Porcine Skin (2020) · cites this paper as [23]

    The Results section (‘C. auris undergoes karyotype rearrangements in stress conditions’; page unavailable) documents stress-induced karyotype changes, and the Discussion suggests such changes might aid fitness adaptation. The Introduction describes C. auris as a skin colonizer, but the paper does not link karyotypic plasticity to adaptation or persistence in the skin niche. (LLM, conf=0.88)

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References 94 · Cited by 60

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Authors
Bravo Ruiz, G., Ross, Z. K., Holmes, E., Schelenz, S., Gow, N. A. R., & Lorenz, A.
Affiliations
  • University of Aberdeen (GB)
  • Royal Brompton Hospital (GB)
Corresponding author
Lorenz, Alexander
ORCID
Venue
Current Genetics
Publisher
Springer Science and Business Media LLC
Published
2019-04-24
Volume
65
Issue
5
Pages
1217-1228
ISSN
  • 0172-8083 (ISSN-L)
  • 1432-0983
DOI
10.1007/s00294-019-00976-w
PMC
PMC6744574
OpenAlex
W2910154903
Cited by
60
References
94
Citations by year
2026: 6 · 2025: 7 · 2024: 7 · 2023: 10 · 2022: 7 · 2021: 8 · 2020: 12 · 2019: 3
FWCI
2.48
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Genetics (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Aberdeen University Research Archive (Aberdeen University) (submittedVersion, cc-by-nc-nd)
  • Figshare (submittedVersion, cc-by)
  • Open Research Exeter (University of Exeter) (submittedVersion, cc-by)
  • Spiral (Imperial College London) (submittedVersion, cc-by)
Funders
  • Medical Research Council (MR/P501955/1, MR/N006364/1)
  • Wellcome Trust (204815/Z/16/Z, 080088, 086827, 075470, 099215, 097377)
  • Tenovus (G17.02)
  • Royal Society (RG140254)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Keywords
Candida auris, haploid yeast, chromosome number variation, clade diversity, genotoxic stress, heat stress, osmotic stress, antifungal resistance, fungal population dynamics, emerging fungal pathogens
MeSH terms
Candida, Candidiasis, Cell Cycle, Haploidy, Stress, Physiological, Chromosomes, Fungal, Genome, Fungal, Evolution, Molecular, Karyotype

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