Genome structure and dynamics of the yeast pathogen Candida glabrata
Open accessAbstract
The yeast pathogen Candida glabrata is the second most frequent cause of Candida infections. However, from the phylogenetic point of view, C. glabrata is much closer to Saccharomyces cerevisiae than to Candida albicans. Apparently, this yeast has relatively recently changed its life style and become a successful opportunistic pathogen. Recently, several C. glabrata sister species, among them clinical and environmental isolates, have had their genomes characterized. Also, hundreds of C. glabrata clinical isolates have been characterized for their genomes. These isolates display enormous genomic plasticity. The number and size of chromosomes vary drastically, as well as intra- and interchromosomal segmental duplications occur frequently. The observed genome alterations could affect phenotypic properties and thus help to adapt to the highly variable and harsh habitats this yeast finds in different human patients and their tissues. Further genome sequencing of pathogenic isolates will provide a valuable tool to understand the mechanisms behind genome dynamics and help to elucidate the genes contributing to the virulence potential.
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Other investigations led to similar claims based on differences among karyotypes of serial clinical isolates of C. glabrata exhibiting increased resistance to antifungals.
“Other investigations led to similar claims based on differences among karyotypes of serial clinical isolates of the species exhibiting an increased resistance to antifungals [130].”
From Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens (2018) · cites this paper as [130]
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- Authors
- Ahmad, K. M., Kokošar, J., Guo, X., Gu, Z., Ishchuk, O. P., & Piškur, J.
- Affiliations
- Lund University (SE)
- Cornell University (US)
- Corresponding author
- Ahmad, Khadija M.
- Venue
- FEMS Yeast Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-06-01
- Volume
- 14
- Issue
- 4
- Pages
- 529-535
- ISSN
- 1567-1356 (ISSN-L)
- 1567-1364
- PMC
- PMC4320752
- OpenAlex
- W2003094568
- Cited by
- 57
- References
- 54
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 2
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- FEMS Yeast Research (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Vetenskapsrådet
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI085286, AI085286)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- Candida glabrata, genome structure, genome dynamics, genome plasticity, chromosome number variation, segmental duplication, candidiasis, clinical isolates, environmental isolates, virulence genes
- MeSH terms
- Adaptation, Biological, Gene Rearrangement, Genome, Fungal, Gene Order, Candida glabrata, Genomic Structural Variation
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