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Cited by 94Advanced X-ray and CT ImagingBone health and osteoporosis researchDigital Radiography and Breast Imaging

Accuracy of bone mineral density quantification using dual-layer spectral detector CT: a phantom study

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van Hamersvelt, Robbert W., Schilham, Arnold M. R., Engelke, Klaus, den Harder, Annemarie M., de Keizer, Bart, Verhaar, Harald J., Leiner, Tim, de Jong, Pim A. +1 more·2017·European Radiology
DOI 10.1007/s00330-017-4801-4PMC PMC5579207
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Abstract

To investigate the accuracy of bone mineral density (BMD) quantification using dual-layer spectral detector CT (SDCT) at various scan protocols. Two validated anthropomorphic phantoms containing inserts of 50–200 mg/cm 3 calcium hydroxyapatite (HA) were scanned using a 64-slice SDCT scanner at various acquisition protocols (120 and 140 kVp, and 50, 100 and 200 mAs). Regions of interest (ROIs) were placed in each insert and mean attenuation profiles at monochromatic energy levels (90–200 keV) were constructed. These profiles were fitted to attenuation profiles of pure HA and water to calculate HA concentrations. For comparison, one phantom was scanned using dual energy X-ray absorptiometry (DXA). At both 120 and 140 kVp, excellent correlations (R = 0.97, P < 0.001) were found between true and measured HA concentrations. Mean error for all measurements at 120 kVp was -5.6 ± 5.7 mg/cm 3 (-3.6 ± 3.2%) and at 140 kVp -2.4 ± 3.7 mg/cm 3 (-0.8 ± 2.8%). Mean measurement errors were smaller than 6% for all acquisition protocols. Strong linear correlations (R 2 ≥ 0.970, P < 0.001) with DXA were found. SDCT allows for accurate BMD quantification and potentially opens up the possibility for osteoporosis evaluation and opportunistic screening in patients undergoing SDCT for other clinical indications. However, patient studies are needed to extend and translate our findings. • Dual - layer spectral detector CT allows for accurate bone mineral density quantification . • BMD measurements on SDCT are strongly linearly correlated to DXA . • SDCT , acquired for several indications , may allow for evaluation of osteoporosis . • This potentially opens up the possibility for opportunistic osteoporosis screening .

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Cited by

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Authors
van Hamersvelt, R. W., Schilham, A. M. R., Engelke, K., den Harder, A. M., de Keizer, B., Verhaar, H. J., Leiner, T., de Jong, P. A., & Willemink, M. J.
Affiliations
  • University Medical Center Utrecht (NL)
  • Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
ORCID
Venue
European Radiology
Publisher
Springer Science and Business Media LLC
Published
2017-04-03
Volume
27
Issue
10
Pages
4351-4359
ISSN
  • 0938-7994 (ISSN-L)
  • 1432-1084
DOI
10.1007/s00330-017-4801-4
PMC
PMC5579207
OpenAlex
W2604280289
Cited by
94
References
2
Citations by year
2026: 5 · 2025: 15 · 2024: 11 · 2023: 10 · 2022: 11 · 2021: 8 · 2020: 9 · 2019: 8 · 2018: 11 · 2017: 6
FWCI
4.19
Type
journal article
Language
en
Open access
Licence
Locations
  • European Radiology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
Funders
University Medical Center Utrecht
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Advanced X-ray and CT Imaging
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Digital Radiography and Breast Imaging
Keywords
dual-layer spectral detector CT, dual-energy X-ray absorptiometry comparison, osteoporosis screening, acquisition protocol, measurement accuracy
MeSH terms
Humans, Osteoporosis, Tomography, X-Ray Computed, Absorptiometry, Photon, Bone Density, Phantoms, Imaging

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