Cited by 41Advanced X-ray and CT ImagingBone health and osteoporosis researchMedical Imaging and Analysis

The accuracy of bone mineral density measurement using dual-energy spectral CT and quantitative CT: a comparative phantom study

Li, X., Li, X., Li, J., Jiao, X., Jia, X., Zhang, X., Fan, G., Yang, J. +1 more·2020·Clinical Radiology

Abstract

Aim To compare bone mineral density (BMD) measurement accuracy by dual-energy spectral computed tomography (CT) and quantitative CT (QCT) using an anthropomorphic European spine phantom (ESP). Materials and methods An ESP containing three hydroxyapatite inserts with densities of 50, 100, and 200 mg/cm 3 was scanned 10 times each using spectral CT and QCT protocols. Their BMD values were measured using hydroxyapatite-based spectral CT material decomposition images and QCT images and compared with the true values in ESP. Results Both protocols had good repeatability in BMD measurement with low coefficient-of-variance (spectral CT: 3 hydroxyapatite insert with relative errors of 2.34% (48.83±1.13 mg/cm 3 ), 2% (98±1.25 mg/cm 3 ) and 5.96% (188.09±2.11 mg/cm 3 ), in spectral CT, and 11% (55.5±0.65 mg/cm 3 ), 9.85% (109.85±0.42 mg/cm 3 ) and 4.04% (208.07±0.54 mg/cm 3 ) in QCT, respectively. Conclusion BMD can be accurately measured using either QCT or spectral CT, and spectral CT has smaller bias than QCT.

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Crossref · 10.1016/j.crad.2019.11.008

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Authors
Li, X., Li, X., Li, J., Jiao, X., Jia, X., Zhang, X., Fan, G., Yang, J., & Guo, J.
Affiliations
First Affiliated Hospital of Xi'an Jiaotong University (CN)
Corresponding author
  • Yang, J.
  • Guo, J.
Venue
Clinical Radiology
Publisher
Elsevier BV
Published
2020-04
Volume
75
Issue
4
Pages
320.e9-320.e15
ISSN
0009-9260 (ISSN-L)
OpenAlex
W2998188360
Cited by
41
References
16
Citations by year
2026: 3 · 2025: 9 · 2024: 8 · 2023: 7 · 2022: 9 · 2021: 3 · 2020: 2
FWCI
1.24
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Radiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Agriculture Department of Shaanxi Province
  • GE Healthcare
  • Xi’an Jiaotong University (XJTU1AF-3D-2018-003)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Advanced X-ray and CT Imaging
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Physical Sciences › Engineering › Biomedical Engineering › Medical Imaging and Analysis
Keywords
bone mineral density, dual-energy CT, quantitative computed tomography, measurement accuracy, measurement bias, repeatability, material decomposition
MeSH terms
Humans, Spine, Tomography, X-Ray Computed, Bone Density, Radiography, Dual-Energy Scanned Projection, Phantoms, Imaging

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