The accuracy of bone mineral density measurement using dual-energy spectral CT and quantitative CT: a comparative phantom study
Abstract
Aim To compare bone mineral density (BMD) measurement accuracy by dual-energy spectral computed tomography (CT) and quantitative CT (QCT) using an anthropomorphic European spine phantom (ESP). Materials and methods An ESP containing three hydroxyapatite inserts with densities of 50, 100, and 200 mg/cm 3 was scanned 10 times each using spectral CT and QCT protocols. Their BMD values were measured using hydroxyapatite-based spectral CT material decomposition images and QCT images and compared with the true values in ESP. Results Both protocols had good repeatability in BMD measurement with low coefficient-of-variance (spectral CT: 3 hydroxyapatite insert with relative errors of 2.34% (48.83±1.13 mg/cm 3 ), 2% (98±1.25 mg/cm 3 ) and 5.96% (188.09±2.11 mg/cm 3 ), in spectral CT, and 11% (55.5±0.65 mg/cm 3 ), 9.85% (109.85±0.42 mg/cm 3 ) and 4.04% (208.07±0.54 mg/cm 3 ) in QCT, respectively. Conclusion BMD can be accurately measured using either QCT or spectral CT, and spectral CT has smaller bias than QCT.
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These findings are in line with previous reports using quantitative CT, dual-energy CT, and dual-energy CT-based localizer radiographs.
“These findings are in line with previous reports using quantitative CT,18 dual-energy CT,18–20 and dual-energy CT–based localizer radiographs.10”
From In Vivo Bone Mineral Density Assessment With Spectral Localizer Radiographs From Photon-Counting Detector CT (2025) · cites this paper as [18]
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- Authors
- Li, X., Li, X., Li, J., Jiao, X., Jia, X., Zhang, X., Fan, G., Yang, J., & Guo, J.
- Affiliations
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Corresponding author
- Yang, J.
- Guo, J.
- Venue
- Clinical Radiology
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 75
- Issue
- 4
- Pages
- 320.e9-320.e15
- ISSN
- 0009-9260 (ISSN-L)
- OpenAlex
- W2998188360
- Cited by
- 41
- References
- 16
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 8 · 2023: 7 · 2022: 9 · 2021: 3 · 2020: 2
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Radiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agriculture Department of Shaanxi Province
- GE Healthcare
- Xi’an Jiaotong University (XJTU1AF-3D-2018-003)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Advanced X-ray and CT Imaging
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Physical Sciences › Engineering › Biomedical Engineering › Medical Imaging and Analysis
- Keywords
- bone mineral density, dual-energy CT, quantitative computed tomography, measurement accuracy, measurement bias, repeatability, material decomposition
- MeSH terms
- Humans, Spine, Tomography, X-Ray Computed, Bone Density, Radiography, Dual-Energy Scanned Projection, Phantoms, Imaging
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