DXA-equivalent quantification of bone mineral density using dual-layer spectral CT scout scans
Abstract
Objectives To develop and evaluate a method for areal bone mineral density (aBMD) measurement based on dual-layer spectral CT scout scans. Methods A post-processing algorithm using a pair of 2D virtual mono-energetic scout images (VMSIs) was established in order to semi-automatically compute the aBMD at the spine similarly to DXA, using manual soft tissue segmentation, semi-automatic segmentation for the vertebrae, and automatic segmentation for the background. The method was assessed based on repetitive measurements of the standardized European Spine Phantom (ESP) using the standard scout scan tube current (30 mA) and other tube currents (10 to 200 mA), as well as using fat-equivalent extension rings simulating different patient habitus, and was compared to dual-energy X-ray absorptiometry (DXA). Moreover, the feasibility of the method was assessed in vivo in female patients. Results Derived from standard scout scans, aBMD values measured with the proposed method significantly correlated with DXA measurements (r = 0.9925, p Conclusions Based on dual-layer spectral scout scans, aBMD measurements were fast and reliable and significantly correlated with the according DXA measurements in phantoms. Considering the number of CT acquisitions performed worldwide, this method could allow truly opportunistic osteoporosis screening. Key points • 2D scout scans (localizer radiographs) from a dual-layer spectral CT scanner, which are mandatory parts of a CT examination, can be used to au…
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These findings are in line with previous reports using quantitative CT, dual-energy CT, and dual-energy CT-based localizer radiographs.
“These findings are in line with previous reports using quantitative CT,18 dual-energy CT,18–20 and dual-energy CT–based localizer radiographs.10”
From In Vivo Bone Mineral Density Assessment With Spectral Localizer Radiographs From Photon-Counting Detector CT (2025) · cites this paper as [10]
Alternatively, 1 localizer radiograph obtained with a dual-layer CT scanner enables quantification of the aBMD.
“Alternatively, 1 localizer radiograph obtained with a dual-layer CT scanner enables quantification of the aBMD.10”
From In Vivo Bone Mineral Density Assessment With Spectral Localizer Radiographs From Photon-Counting Detector CT (2025) · cites this paper as [10]
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- Authors
- Laugerette, A., Schwaiger, B. J., Brown, K., Frerking, L. C., Kopp, F. K., Mei, K., Sellerer, T., Kirschke, J., Baum, T., Gersing, A. S., Pfeiffer, D., Fingerle, A. A., Rummeny, E. J., Proksa, R., Noël, P. B., & Pfeiffer, F.
- Affiliations
- TUM Klinikum (DE)
- Philips (Germany) (DE)
- Technical University of Munich (DE)
- Corresponding author
- Noël, Peter B.
- ORCID
- Venue
- European Radiology
- Published
- 2019-02-13
- Volume
- 29
- Issue
- 9
- Pages
- 4624-4634
- ISSN
- 0938-7994 (ISSN-L)
- 1432-1084
- OpenAlex
- W2911756823
- Cited by
- 29
- References
- 33
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 6 · 2019: 1
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Radiology (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Funders
- BMBF (13GW0072C)
- DFG (GRK2274)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Physical Sciences › Engineering › Biomedical Engineering › Advanced X-ray and CT Imaging
- Physical Sciences › Engineering › Biomedical Engineering › Medical Imaging and Analysis
- Keywords
- spectral CT, dual-layer spectral CT, spine, osteoporosis screening, opportunistic screening, tube current, soft tissue segmentation, vertebral segmentation, precision and accuracy, female patients
- MeSH terms
- Adult, Age Factors, Aged, Algorithms, Feasibility Studies, Female, Humans, Image Processing, Computer-Assisted, Middle Aged, Osteoporosis, Spine, Tomography, X-Ray Computed, Reproducibility of Results, Bone Density, Phantoms, Imaging, Young Adult
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