Risk of colorectal cancer in patients with periodontal disease severity: a nationwide, population-based cohort study
Abstract
Background Periodontal disease (PD) and colorectal cancer (CRC) were associated with chronic inflammation. This retrospective cohort study examined the association between PD severity and CRC in a large-scale, population-based Chinese cohort.Methods A total of approximately 106,487 individuals with newly diagnosed PD and 106,487 age-matched and sex-matched patients without PD from 2000 to 2002 were identified from Taiwan's National Health Insurance Research Database (NHIRD).Results The Kaplan-Meier analysis revealed that the cumulative incidence of CRC was significantly higher in patients with PD than in those without PD (log-rank test, P < 0.001). After adjustment for age, sex, and comorbidities, patients with PD were associated with a significantly higher risk of CRC compared with those without PD (adjusted HR = 1.64, 95% CI = 1.50-1.80). Further, the risk of CRC appeared to increase with increasing frequency of PD medical visits [adjusted HR (95% CI) was 1.78 (1.58-2.02) and 1.53 (1.35-1.74) for annual visits > 10 and < 4, respectively].Conclusion Based on our study, PD severity was associated with an increase in the risk of CRC. Further mechanistic research is needed.
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These findings support the reported association between periodontal disease and colorectal cancer risk.
“These findings support the reported association of periodontal disease with CRC risk.38, 56, 57”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [56]
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- Authors
- Hu, J.-M., Shen, C.-J., Chou, Y.-C., Hung, C.-F., Tian, Y.-F., You, S.-L., Chen, C.-Y., Hsu, C.-H., Hsiao, C.-W., Lin, C.-Y., & Sun, C.-A.
- Affiliations
- Tri-Service General Hospital (TW)
- National Defense Medical Center (TW)
- Fu Jen Catholic University (TW)
- Taichung Veterans General Hospital (TW)
- Corresponding author
- Sun, Chien-An
- ORCID
- Venue
- International Journal of Colorectal Disease
- Published
- 2018-02-03
- Volume
- 33
- Issue
- 3
- Pages
- 349-352
- ISSN
- 0179-1958 (ISSN-L)
- 1432-1262
- OpenAlex
- W2789761120
- Cited by
- 39
- References
- 12
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 2 · 2023: 9 · 2022: 5 · 2021: 2 · 2020: 7 · 2019: 4
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- International Journal of Colorectal Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- periodontal disease, colorectal cancer, cancer risk, chronic inflammation, periodontal disease severity, Chinese population
- MeSH terms
- Adult, Female, Humans, Male, Periodontal Diseases, Risk Factors, Severity of Illness Index, Colorectal Neoplasms, Cohort Studies, Kaplan-Meier Estimate
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