Co-occurrence of anaerobic bacteria in colorectal carcinomas
Open accessAbstract
Background: Numerous cancers have been linked to microorganisms. Given that colorectal cancer is a leading cause of cancer deaths and the colon is continuously exposed to a high diversity of microbes, the relationship between gut mucosal microbiome and colorectal cancer needs to be explored. Metagenomic studies have shown an association between Fusobacterium species and colorectal carcinoma. Here, we have extended these studies with deeper sequencing of a much larger number (n = 130) of colorectal carcinoma and matched normal control tissues. We analyzed these data using co-occurrence networks in order to identify microbe-microbe and host-microbe associations specific to tumors. Results: We confirmed tumor over-representation of Fusobacterium species and observed significant co-occurrence within individual tumors of Fusobacterium, Leptotrichia and Campylobacter species. This polymicrobial signature was associated with over-expression of numerous host genes, including the gene encoding the pro-inflammatory chemokine Interleukin-8. The tumor-associated bacteria we have identified are all Gram-negative anaerobes, recognized previously as constituents of the oral microbiome, which are capable of causing infection. We isolated a novel strain of Campylobacter showae from a colorectal tumor specimen. This strain is substantially diverged from a previously sequenced oral Campylobacter showae isolate, carries potential virulence genes, and aggregates with a previously isolated tumor strain of Fusobacterium nucleatum. Conclusions: A polymicrobial signature of Gram-negative anaerobic bacteria is associated with colorectal carcinoma tissue.
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Colorectal cancers have an increased enrichment of opportunistic pathogens and polymicrobial Gram-negative anaerobic bacteria.
“CRCs have an increased enrichment of opportunistic pathogens and polymicrobial Gram-negative anaerobic bacteria91”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [91]
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- Authors
- Warren, R. L., Freeman, D. J., Pleasance, S., Watson, P., Moore, R. A., Cochrane, K., Allen-Vercoe, E., & Holt, R. A.
- Affiliations
- BC Cancer Agency (CA)
- University of Guelph (CA)
- Corresponding author
- Holt, Robert A
- Venue
- Microbiome
- Published
- 2013-05-15
- Volume
- 1
- Issue
- 1
- Pages
- 16-16
- ISSN
- 2049-2618 (ISSN-L)
- PMC
- PMC3971631
- OpenAlex
- W2122131141
- Cited by
- 348
- References
- 50
- Citations by year
- 2026: 18 · 2025: 24 · 2024: 30 · 2023: 28 · 2022: 37 · 2021: 35 · 2020: 39 · 2019: 33 · 2018: 26 · 2017: 20 · 2016: 27 · 2015: 21 · 2014: 8 · 2013: 1
- FWCI
- 8.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Microbiome (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Summit (Simon Fraser University) (submittedVersion, cc-by)
- Funders
- Genome British Columbia (SOF128)
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- colorectal cancer, anaerobic bacteria, Fusobacterium, Campylobacter showae, Leptotrichia, host-microbe interactions, co-occurrence networks, interleukin-8, Gram-negative bacteria, gut microbiota, Fusobacterium nucleatum, virulence genes, oral microbiota
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