Dietary choline and betaine; associations with subclinical markers of cardiovascular disease risk and incidence of CVD, coronary heart disease and stroke: the Jackson Heart Study
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Purpose Several mechanisms have been described through which dietary intake of choline and its derivative betaine may be associated in both directions with subclinical atherosclerosis. We assessed the association of dietary intake of choline and betaine with cardiovascular risk and markers of subclinical cardiovascular disease.Methods Data from 3924 Jackson Heart Study (JHS) African-American participants with complete food frequency questionnaire at baseline and follow-up measurements of heart disease measures were used. Multivariable linear regression models were employed to assess associations between choline and betaine intake with carotid intima-media thickness, coronary artery calcium, abdominal aortic calcium and left ventricular mass. Cox proportional hazards regression models were used to estimate associations with time to incident coronary heart disease (CHD), ischemic stroke and cardiovascular disease (CVD).Results During an average nine years of follow-up, 124 incident CHD events, 75 incident stroke events and 153 incident CVD events were documented. In women, greater choline intake was associated with lower left ventricular mass (p = 0.0006 for trend across choline quartiles) and with abdominal aortic calcium score. Among all JHS participants, there was a statistically significant inverse association between dietary choline intake and incident stroke, β = -0.33 (p = 0.04). Betaine intake was associated with greater risk of incident CHD when comparing the third quartile of intake with the lowest quartile of intake (HR 1.89, 95 % CI 1.14, 3.15).Conclusions Among our African-American participants, higher dietary choline intake was associated with a lower risk of incident ischemic stroke, and thus putative dietary benefits. Higher dietary betaine intake was associated with a nonlinear higher risk of incident CHD.
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In the Jackson Heart Study (3,924 African-Americans), higher dietary choline was associated with reduced risk of incident ischemic stroke.
“In the Jackson Heart Study, involving 3,924 African-Americans, higher dietary choline was associated with reduced risk of incident ischemic stroke, whereas higher betaine intake was associated with a nonlinear higher risk of incident coronary heart disease (78).”
From Trimethylamine <i>N</i> -Oxide, the Microbiome, and Heart and Kidney Disease (2017) · cites this paper as [78]
In the Jackson Heart Study, higher betaine intake was associated with a nonlinear higher risk of incident coronary heart disease.
“In the Jackson Heart Study, involving 3,924 African-Americans, higher dietary choline was associated with reduced risk of incident ischemic stroke, whereas higher betaine intake was associated with a nonlinear higher risk of incident coronary heart disease (78).”
From Trimethylamine <i>N</i> -Oxide, the Microbiome, and Heart and Kidney Disease (2017) · cites this paper as [78]
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Choline status and related health outcomes in humans: A scoping review
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- Authors
- Millard, H. R., Musani, S. K., Dibaba, D. T., Talegawkar, S. A., Taylor, H. A., Tucker, K. L., & Bidulescu, A.
- Affiliations
- Indiana University Bloomington (US)
- University of Mississippi Medical Center (US)
- Johns Hopkins University (US)
- Morehouse School of Medicine (US)
- University of Massachusetts Lowell (US)
- Corresponding author
- Bidulescu, Aurelian
- ORCID
- Venue
- European Journal of Nutrition
- Published
- 2016-08-22
- Volume
- 57
- Issue
- 1
- Pages
- 51-60
- ISSN
- 1436-6207 (ISSN-L)
- 1436-6215
- PMC
- PMC5931705
- OpenAlex
- W2508273478
- Cited by
- 101
- References
- 54
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 16 · 2023: 18 · 2022: 14 · 2021: 15 · 2020: 11 · 2019: 5 · 2018: 4 · 2017: 6
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- European Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks Open (Indiana University) (submittedVersion)
- Funders
- Foundation for the National Institutes of Health (N01-HC-95170)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- dietary choline, betaine, cardiovascular risk, coronary artery disease, ischemic stroke, subclinical atherosclerosis, carotid intima-media thickness, coronary artery calcium, left ventricular mass, African American adults, Jackson Heart Study
- MeSH terms
- Adult, Aged, Aged, 80 and over, Betaine, Black or African American, Cardiovascular Diseases, Choline, Coronary Disease, Diet, Female, Humans, Male, Middle Aged, Mississippi, Surveys and Questionnaires, Risk Factors, Diet Records, Proportional Hazards Models, Stroke, Black People
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