Obesity and mental health improvement following nutritional education focusing on gut microbiota composition in Japanese women: a randomised controlled trial
Abstract
Purpose Gut microbiota composition was supposedly related to obesity and psychological factors. We examined the effects of a nutritional education intervention focusing on gut microbiota composition on obesity and psychological factors among obese women.Methods Forty-four obese Japanese women aged 40 or older were randomly assigned to either an intervention group (n = 22) or control group (n = 22). The intervention consisted of a 20-min dietary lecture and a 10-min counselling session by registered dieticians, every 2 weeks for eight consecutive weeks. Body weight, height, waist circumference, food frequency, and gut microbiota composition were measured, and self-rated health and psychological factors were scored before and after the intervention.Results All participants completed the 8 week program. After the intervention, dietary fibre intake (p < 0.01), frequency of vegetable consumption (p = 0.020), and frequency of milk and milk product consumption (p < 0.01) increased significantly in the intervention group compared with the control group. Body weight and body mass index (BMI; p < 0.001), waist circumference (p < 0.01), and the depression scale score (p < 0.01) decreased significantly, while significant improvements were found in self-rated health (p = 0.045) and microbiome diversity (p < 0.01).Conclusion Nutritional education focusing on gut microbiota composition may improve obesity and psychological factors in obese women.
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In an obese population, a nutrition education program focusing on the gut microbiota resulted in a decrease in the depression score and an increase in self-rated health, as well as an increase in alpha-diversity and abundance of beneficial bacteria such as B. bifidum and S. thermophilus.
“In an obese population, a nutrition education program focusing on the gut microbiota (increase in fiber-containing and fermented foods) resulted in a decrease in the depression score and an increase in selfrated health, as well as an increase in α-diversity and abundance of beneficial bacteria such as B. bifidum and S. thermophilus (332).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [332]
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Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
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- Authors
- Uemura, M., Hayashi, F., Ishioka, K., Ihara, K., Yasuda, K., Okazaki, K., Omata, J., Suzutani, T., Hirakawa, Y., Chiang, C., Aoyama, A., & Ohira, T.
- Affiliations
- Fukushima Medical University (JP)
- Center for Gene Research, Nagoya University (JP)
- Tosei General Hospital (JP)
- Nagoya University (JP)
- Corresponding author
- Uemura, Mayu
- ORCID
- Venue
- European Journal of Nutrition
- Published
- 2018-12-06
- Volume
- 58
- Issue
- 8
- Pages
- 3291-3302
- ISSN
- 1436-6207 (ISSN-L)
- 1436-6215
- OpenAlex
- W2902804186
- Cited by
- 52
- References
- 38
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 4 · 2023: 9 · 2022: 14 · 2021: 8 · 2020: 5 · 2019: 1
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- THE SKYLARK FOOD SCIENCE INSTITUTE
- Fostering Research Fund at Fukushima Medical University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Keywords
- obesity, gut microbiota, nutrition education, nutrition counseling, depression, self-rated health, dietary fiber intake, vegetable consumption, milk consumption, microbiome diversity, body mass index, waist circumference, Japanese women
- MeSH terms
- Gastrointestinal Microbiome, Adult, Mental Disorders, Diet, Female, Humans, Japan, Obesity, Patient Education as Topic, Treatment Outcome
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