Cited by 135Schizophrenia research and treatmentBipolar Disorder and TreatmentNeuroscience and Neuropharmacology Research

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Bipolar disorder type 1 and schizophrenia are accompanied by decreased density of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region

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Wang, Alice Y., Lohmann, Kathryn M., Yang, C. Kevin, Zimmerman, Eric I., Pantazopoulos, Harry, Herring, Nicole, Berretta, Sabina, Heckers, Stephan, Konradi, Christine·2011·Acta Neuropathologica

DOI 10.1007/s00401-011-0881-4PMC PMC4207060

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Abstract

GABAergic interneurons synchronize network activities and monitor information flow. Post-mortem studies have reported decreased densities of cortical interneurons in schizophrenia (SZ) and bipolar disorder (BPD). The entorhinal cortex (EC) and the adjacent subicular regions are a hub for integration of hippocampal and cortical information, a process that is disrupted in SZ. Here we contrast and compare the density of interneuron populations in the caudal EC and subicular regions in BPD type I (BPD-I), SZ, and normal control (NC) subjects. Post-mortem human parahippocampal specimens of 13 BPD-I, 11 SZ and 17 NC subjects were used to examine the numerical density of parvalbumin-, somatostatin- or calbindin-positive interneurons. We observed a reduction in the numerical density of parvalbumin- and somatostatin-positive interneurons in the caudal EC and parasubiculum in BPD-I and SZ, but no change in the subiculum. Calbindin-positive interneuron densities were normal in all brain areas examined. The profile of decreased density was strikingly similar in BPD-I and SZ. Our results demonstrate a specific reduction of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region in BPD-I and SZ, likely disrupting synchronization and integration of cortico-hippocampal circuits.

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Authors: Wang, A. Y., Lohmann, K. M., Yang, C. K., Zimmerman, E. I., Pantazopoulos, H., Herring, N., Berretta, S., Heckers, S., & Konradi, C.
Affiliations: Vanderbilt University (US)
Harvard University (US)
Corresponding author: Konradi, Christine
ORCID: Zimmerman, Eric I.
Pantazopoulos, Harry
Herring, Nicole
Berretta, Sabina
Heckers, Stephan
Konradi, Christine
Venue: Acta Neuropathologica
Publisher: Springer Science and Business Media LLC
Published: 2011-10-04
Volume: 122
Issue: 5
Pages: 615-626
ISSN: 0001-6322 (ISSN-L)
1432-0533
DOI: 10.1007/s00401-011-0881-4
PMC: PMC4207060
OpenAlex: W2141284711
Cited by: 135
References: 62
Citations by year: 2026: 4 · 2025: 10 · 2024: 10 · 2023: 10 · 2022: 11 · 2021: 8 · 2020: 13 · 2019: 11 · 2018: 12 · 2017: 7 · 2016: 6 · 2015: 9 · 2014: 11 · 2013: 7 · 2012: 5
FWCI: 5.03
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Acta Neuropathologica (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH067999, R24MH068855, MH 068855, MH67999)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: bipolar I disorder, schizophrenia, parvalbumin interneurons, somatostatin interneurons, GABAergic interneurons, entorhinal cortex, parasubiculum, subiculum, parahippocampal region, interneuron density, network synchronization
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Autopsy, Bipolar Disorder, Cell Count, Female, Hippocampus, Humans, Interneurons, Male, Middle Aged, Nerve Net, Parvalbumins, Schizophrenia, Somatostatin, Case-Control Studies, Entorhinal Cortex, Parahippocampal Gyrus, Young Adult, Calbindins, S100 Calcium Binding Protein G

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Bipolar disorder type 1 and schizophrenia are accompanied by decreased density of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region

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