Cited by 189Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCongenital heart defects research

Cortical interneuron development: a tale of time and space

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Hu, Jia Sheng, Vogt, Daniel, Sandberg, Magnus, Rubenstein, John L.·2017·Development

Abstract

Cortical interneurons are a diverse group of neurons that project locally and are crucial for regulating information processing and flow throughout the cortex. Recent studies in mice have advanced our understanding of how these neurons are specified, migrate and mature. Here, we evaluate new findings that provide insights into the development of cortical interneurons and that shed light on when their fate is determined, on the influence that regional domains have on their development, and on the role that key transcription factors and other crucial regulatory genes play in these events. We focus on cortical interneurons that are derived from the medial ganglionic eminence, as most studies have examined this interneuron population. We also assess how these data inform our understanding of neuropsychiatric disease and discuss the potential role of cortical interneurons in cell-based therapies.

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  • After becoming postmitotic, interneurons migrate tangentially toward cortical areas and then radially into predetermined cortical layers.

    “Once postmitotic, cells migrate tangentially toward cortical areas and then radially into predetermined cortical layers (Fig. 2, steps 1a, 1b, and 2), [129, 130].”

    From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [129]

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Authors
Hu, J. S., Vogt, D., Sandberg, M., & Rubenstein, J. L.
Affiliations
University of California, San Francisco (US)
Venue
Development
Published
2017-11-01
Volume
144
Issue
21
Pages
3867-3878
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
OpenAlex
W2765697964
Cited by
189
References
131
Citations by year
2026: 7 · 2025: 17 · 2024: 21 · 2023: 22 · 2022: 27 · 2021: 24 · 2020: 33 · 2019: 23 · 2018: 14 · 2017: 1
FWCI
2.95
Type
journal article
Language
en
Open access
Locations
  • Development (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
  • National Institute of Mental Health (T32 MH089920, R37 MH049428, R01 MH081880)
  • Brain and Behavior Research Foundation
  • Clinical and Translational Science Institute, University of California, San Francisco (1111111)
  • Vetenskapsrådet (2011-38865-83000-30)
  • Svenska Sällskapet för Medicinsk Forskning
  • Nina Ireland
  • Simons Foundation (309279)
  • U.S. Department of Defense (TS150059)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords
cortical interneurons, interneuron development, medial ganglionic eminence, neuronal specification, neuronal migration, transcription factors, neuropsychiatric disorders, cell therapy, mice
MeSH terms
Animals, Cerebral Cortex, Interneurons, Models, Biological, Time Factors, Transcription, Genetic, Cell Lineage

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