Cited by 158Schizophrenia research and treatmentNeuroscience and Neuropharmacology ResearchTryptophan and brain disorders

Targeting Oxidative Stress and Aberrant Critical Period Plasticity in the Developmental Trajectory to Schizophrenia

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Do, Kim Q., Cuenod, Michel, Hensch, Takao K.·2015·Schizophrenia Bulletin

Abstract

Schizophrenia is a neurodevelopmental disorder reflecting a convergence of genetic risk and early life stress. The slow progression to first psychotic episode represents both a window of vulnerability as well as opportunity for therapeutic intervention. Here, we consider recent neurobiological insight into the cellular and molecular components of developmental critical periods and their vulnerability to redox dysregulation. In particular, the consistent loss of parvalbumin-positive interneuron (PVI) function and their surrounding perineuronal nets (PNNs) as well as myelination in patient brains is consistent with a delayed or extended period of circuit instability. This linkage to critical period triggers (PVI) and brakes (PNN, myelin) implicates mistimed trajectories of brain development in mental illness. Strategically introduced antioxidant treatment or later reinforcement of molecular brakes may then offer a novel prophylactic psychiatry.

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Crossref · 10.1093/schbul/sbv065

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165 of 165 references verified0 citation errors · 0 not checkable

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  • Neural-structural changes may mediate ELA effects on depression, while sensitive period disruption may contribute to schizophrenia and autism pathogenesis.

    “Studies suggest that neural-structural changes mediate ELA effects on depression [38], while sensitive period disruption may contribute to schizophrenia and autism pathogenesis [30, 39].”
  • Lifetime omega-3 fatty acid, vitamin, sulforaphane, and prebiotic supplementation are effective universal prevention interventions to support good mental health by reducing neuroinflammation, oxidative stress, and microbiota dysbiosis.

    “lifetime omega-3 fatty acid [56–58], vitamin [57–59], sulforaphane [60], and prebiotic [61] supplementation to support good mental health by reducing neuroinflammation, oxidative stress, and microbiota dysbiosis”

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Authors
Do, K. Q., Cuenod, M., & Hensch, T. K.
Affiliations
Harvard University (US)
Corresponding author
Hensch, Takao K.
Venue
Schizophrenia Bulletin
Published
2015-06-01
Volume
41
Issue
4
Pages
835-846
ISSN
  • 0586-7614 (ISSN-L)
  • 1745-1701
OpenAlex
W2200686875
Cited by
158
References
165
Citations by year
2026: 6 · 2025: 5 · 2024: 6 · 2023: 17 · 2022: 8 · 2021: 16 · 2020: 20 · 2019: 19 · 2018: 15 · 2017: 27 · 2016: 13 · 2015: 6
FWCI
2.79
Type
journal article
Language
en
Open access
Locations
  • Schizophrenia Bulletin (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • reroDoc Digital Library (submittedVersion)
  • IRIS (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
Funders
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (135736, 116689, 310030)
  • National Institute of Mental Health (P50MH094271)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
schizophrenia, oxidative stress
MeSH terms
Animals, Brain, Humans, Neuronal Plasticity, Schizophrenia, Oxidative Stress

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