Targeting Oxidative Stress and Aberrant Critical Period Plasticity in the Developmental Trajectory to Schizophrenia
Open accessAbstract
Schizophrenia is a neurodevelopmental disorder reflecting a convergence of genetic risk and early life stress. The slow progression to first psychotic episode represents both a window of vulnerability as well as opportunity for therapeutic intervention. Here, we consider recent neurobiological insight into the cellular and molecular components of developmental critical periods and their vulnerability to redox dysregulation. In particular, the consistent loss of parvalbumin-positive interneuron (PVI) function and their surrounding perineuronal nets (PNNs) as well as myelination in patient brains is consistent with a delayed or extended period of circuit instability. This linkage to critical period triggers (PVI) and brakes (PNN, myelin) implicates mistimed trajectories of brain development in mental illness. Strategically introduced antioxidant treatment or later reinforcement of molecular brakes may then offer a novel prophylactic psychiatry.
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Colizzi, M., Lasalvia, A., & Ruggeri, M. (2020) · International Journal of Mental Health Systems · doi:10.1186/s13033-020-00356-9 · Cited by 727 · see citing works
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“Studies suggest that neural-structural changes mediate ELA effects on depression [38], while sensitive period disruption may contribute to schizophrenia and autism pathogenesis [30, 39].”
BackgroundThe roles of perineuronal nets and the perinodal extracellular matrix in neuronal function
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Genome-Wide Target Analyses of Otx2 Homeoprotein in Postnatal Cortex
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- Authors
- Do, K. Q., Cuenod, M., & Hensch, T. K.
- Affiliations
- Harvard University (US)
- Corresponding author
- Hensch, Takao K.
- ORCID
- Hensch, Takao K.
- Venue
- Schizophrenia Bulletin
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-06-01
- Volume
- 41
- Issue
- 4
- Pages
- 835-846
- ISSN
- 0586-7614 (ISSN-L)
- 1745-1701
- PMC
- PMC4466197
- OpenAlex
- W2200686875
- Cited by
- 158
- References
- 165
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 6 · 2023: 17 · 2022: 8 · 2021: 16 · 2020: 20 · 2019: 19 · 2018: 15 · 2017: 27 · 2016: 13 · 2015: 6
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Bulletin (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- reroDoc Digital Library (submittedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (135736, 116689, 310030)
- National Institute of Mental Health (P50MH094271)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- schizophrenia, oxidative stress
- MeSH terms
- Animals, Brain, Humans, Neuronal Plasticity, Schizophrenia, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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