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Bipolar disorder type 1 and schizophrenia are accompanied by decreased density of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region
Open accessAbstract
GABAergic interneurons synchronize network activities and monitor information flow. Post-mortem studies have reported decreased densities of cortical interneurons in schizophrenia (SZ) and bipolar disorder (BPD). The entorhinal cortex (EC) and the adjacent subicular regions are a hub for integration of hippocampal and cortical information, a process that is disrupted in SZ. Here we contrast and compare the density of interneuron populations in the caudal EC and subicular regions in BPD type I (BPD-I), SZ, and normal control (NC) subjects. Post-mortem human parahippocampal specimens of 13 BPD-I, 11 SZ and 17 NC subjects were used to examine the numerical density of parvalbumin-, somatostatin- or calbindin-positive interneurons. We observed a reduction in the numerical density of parvalbumin- and somatostatin-positive interneurons in the caudal EC and parasubiculum in BPD-I and SZ, but no change in the subiculum. Calbindin-positive interneuron densities were normal in all brain areas examined. The profile of decreased density was strikingly similar in BPD-I and SZ. Our results demonstrate a specific reduction of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region in BPD-I and SZ, likely disrupting synchronization and integration of cortico-hippocampal circuits.
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“Reductions in the number of PV-INs were reported in the hippocampus, entorhinal cortex, and subicular areas [1,[9][10][11].”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [9]
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“The preponderance of interneuron pathologies in the hippocampus and adjacent cortical areas, such as the interneuron pathologies observed in schizophrenia and BPD, might be, at least in part, a reflection of this extended developmental vulnerability [1, 9, 122, 140-142].”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [9]
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Metadata
- Authors
- Wang, A. Y., Lohmann, K. M., Yang, C. K., Zimmerman, E. I., Pantazopoulos, H., Herring, N., Berretta, S., Heckers, S., & Konradi, C.
- Affiliations
- Vanderbilt University (US)
- Harvard University (US)
- Corresponding author
- Konradi, Christine
- ORCID
- Venue
- Acta Neuropathologica
- Published
- 2011-10-04
- Volume
- 122
- Issue
- 5
- Pages
- 615-626
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- PMC
- PMC4207060
- OpenAlex
- W2141284711
- Cited by
- 135
- References
- 62
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 10 · 2023: 10 · 2022: 11 · 2021: 8 · 2020: 13 · 2019: 11 · 2018: 12 · 2017: 7 · 2016: 6 · 2015: 9 · 2014: 11 · 2013: 7 · 2012: 5
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH067999, R24MH068855, MH 068855, MH67999)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- bipolar I disorder, schizophrenia, parvalbumin interneurons, somatostatin interneurons, GABAergic interneurons, entorhinal cortex, parasubiculum, subiculum, parahippocampal region, interneuron density, network synchronization
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Autopsy, Bipolar Disorder, Cell Count, Female, Hippocampus, Humans, Interneurons, Male, Middle Aged, Nerve Net, Parvalbumins, Schizophrenia, Somatostatin, Case-Control Studies, Entorhinal Cortex, Parahippocampal Gyrus, Young Adult, Calbindins, S100 Calcium Binding Protein G
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