Precision medicine in diagnosis, prognosis, and disease monitoring of bone and soft tissue sarcomas using liquid biopsy: A systematic review
Open accessAbstract
INTRODUCTION: Liquid biopsy as a non-invasive method to investigate cancer biology and monitor residual disease has gained significance in clinical practice over the years. Whilst its applicability in carcinomas is well established, the low incidence and heterogeneity of bone and soft tissue sarcomas explains the less well-established knowledge considering liquid biopsy in these highly malignant mesenchymal neoplasms. MATERIALS AND METHODS: A systematic literature review adhering to the PRISMA guidelines initially identified 920 studies, of whom 68 original articles could be finally included, all dealing with clinical applicability of liquid biopsy in sarcoma. Studies were discussed within two main chapters, i.e. translocation-associated and complex-karyotype sarcomas. RESULTS: Overall, data on clinical applicability of liquid biopsy in 2636 patients with > 10 different entities of bone and soft tissue sarcomas could be summarised. The five most frequent tumour entities included osteosarcoma (n = 602), Ewing sarcoma (n = 384), gastrointestinal stromal tumour (GIST; n = 203), rhabdomyosarcoma (n = 193), and leiomyosarcoma (n = 145). Of 11 liquid biopsy analytes, largest evidence was present for ctDNA and cfDNA, investigated in 26 and 18 studies, respectively. CONCLUSIONS: This systematic literature review provides an extensive up-to-date overview about the current and potential future uses of different liquid biopsy modalities as diagnostic, prognostic, and disease monitoring markers in sarcoma.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Sarcoma diversity includes distinct molecular architectures ranging from translocation-associated tumors with relatively simple genomic profiles to complex-karyotype sarcomas with widespread copy-number alterations, structural instability, methylation changes, and substantial intertumoral heterogeneity.
“Their diversity extends beyond histology to include distinct molecular architectures, ranging from translocation-associated tumors with relatively simple genomic profiles to complex-karyotype sarcomas characterized by widespread copy-number alterations, structural instability, methylation changes, and substantial intertumoral heterogeneity [ 3 , 4 ].”
From Signals Alongside Scans: A Genomics-Guided Framework for Liquid Biopsy in Bone and Soft-Tissue Sarcomas (2026) · cites this paper as [4]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Integrating liquid biopsies into the management of cancer
Siravegna, G., Marsoni, S., Siena, S., & Bardelli, A. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.14 · Cited by 1,941 · see citing works
Current and future perspectives of liquid biopsies in genomics-driven oncology
Heitzer, E., Haque, I. S., Roberts, C. E. S., & Speicher, M. R. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0071-5 · Cited by 1,557 · see citing works
Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin
Snyder, M. W., Kircher, M., Hill, A. J., Daza, R. M., & Shendure, J. (2016) · Cell · doi:10.1016/j.cell.2015.11.050 · Cited by 1,462 · see citing works
Ashley, E. A. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.86 · Cited by 1,116 · see citing works
Circulating tumour cells in cancer patients: challenges and perspectives
Pantel, K., & Alix‐Panabières, C. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.07.001 · Cited by 816 · see citing works
Circulating cell free DNA: Preanalytical considerations
Messaoudi, S. E., Rolet, F., Mouliere, F. C., & Thierry, A. R. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2013.05.022 · Cited by 560 · see citing works
Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma
Barr, F. G., Galili, N., Holick, J., Biegel, J. A., Rovera, G., & Emanuel, B. S. (1993) · Nature Genetics · doi:10.1038/ng0293-113 · Cited by 553 · see citing works
Miettinen, M., Antonescu, C. R., Fletcher, C. D. �., et al. (2017) · Human Pathology · doi:10.1016/j.humpath.2017.05.010 · Cited by 451 · see citing works
Biology of EWS/ETS fusions in Ewing's family tumors
Arvand, A., & Denny, C. T. (2001) · Oncogene · doi:10.1038/sj.onc.1204598 · Cited by 347 · see citing works
Kohler, C., Radpour, R., Barekati, Z., Asadollahi, R., Bitzer, J., Wight, E., Bürki, N., Diesch, C., Holzgreve, W., & Zhong, X. Y. (2009) · Molecular Cancer · doi:10.1186/1476-4598-8-105 · Cited by 215 · see citing works
Peneder, P., Stütz, A. M., Surdez, D., Krumbholz, M., Semper, S., Chicard, M., Sheffield, N. C., Pierron, G., Lapouble, E., Tötzl, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23445-w · Cited by 200 · see citing works
KIT and PDGFRA Mutations and the Risk of GI Stromal Tumor Recurrence
Joensuu, H., Rutkowski, P. L., Nishida, T., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.57.4970 · Cited by 176 · see citing works
Klega, K. S., Imamović, A., Ha, G., Clapp, A. N., Meyer, S. C., Ward, A., Clinton, C., Nag, A., Allen, E. M. V., Mullen, E. A., et al. (2018) · JCO Precision Oncology · doi:10.1200/po.17.00285 · Cited by 139 · see citing works
Suehara, Y., Alex, D., Bowman, A., Middha, S., Zehir, A., Chakravarty, D., Wang, L., Jour, G., Nafa, K., Hayashi, T., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-4032 · Cited by 135 · see citing works
Fujiwara, T., Uotani, K., Yoshida, A., Morita, T., Nezu, Y., Kobayashi, E., Yoshida, A., Uehara, T., Omori, T., Sugiu, K., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16498 · Cited by 118 · see citing works
Integrated microfluidic-SERS for exosome biomarker profiling and osteosarcoma diagnosis
Han, Z., Peng, X., Yang, Y., Yi, J., Zhao, D., Bao, Q., Long, S., Yu, S., Xu, X., Liu, B., et al. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114709 · Cited by 116 · see citing works
Molecular pathology of sarcomas: concepts and clinical implications
Bovée, J. V. M. G., & Hogendoorn, P. C. W. (2009) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-009-0828-5 · Cited by 107 · see citing works
TP53 mutations emerge with HDM2 inhibitor SAR405838 treatment in de-differentiated liposarcoma
Jung, J., Lee, J. S., Dickson, M. A., Schwartz, G. K., Cesne, A. L., Varga, A., Bahleda, R., Wagner, A. J., Choy, E., Jonge, M. J. D., et al. (2016) · Nature Communications · doi:10.1038/ncomms12609 · Cited by 99 · see citing works
Genomic EWSR1 Fusion Sequence as Highly Sensitive and Dynamic Plasma Tumor Marker in Ewing Sarcoma
Krumbholz, M., Hellberg, J., Steif, B., Bäuerle, T., Gillmann, C., Fritscher, T., Agaimy, A., Frey, B., Juengert, J., Wardelmann, E., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-3028 · Cited by 96 · see citing works
MDM2 Amplified Sarcomas: A Literature Review
Sciot, R. (2021) · Diagnostics · doi:10.3390/diagnostics11030496 · Cited by 96 · see citing works
miR-491 Inhibits Osteosarcoma Lung Metastasis and Chemoresistance by Targeting αB-crystallin
Wang, S., Luo, S., Liu, C., Piao, Z.-H., Gou, W., Wang, Y., Guan, W., Li, Q., Zou, H., Yang, Z., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.05.018 · Cited by 94 · see citing works
Detection of tumour cells in peripheral blood and bone marrow from ewing tumour patients by rt‐pcr
Pfleiderer, C., Zoubek, A., Gruber, B., Kronberger, M., Ambros, P. F., Lion, T., Fink, F., Gadner, H., & Kovar, H. (1995) · International Journal of Cancer · doi:10.1002/ijc.2910640211 · Cited by 90 · see citing works
A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes
Asano, N., Matsuzaki, J., Ichikawa, M., Kawauchi, J., Takizawa, S., Aoki, Y., Sakamoto, H., Yoshida, A., Kobayashi, E., Tanzawa, Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09143-8 · Cited by 90 · see citing works
George, S. L., Izquierdo, E., Campbell, J., Koutroumanidou, E., Proszek, P., Jamal, S., Hughes, D., Yuan, L., Marshall, L. V., Carceller, F., et al. (2019) · European Journal of Cancer · doi:10.1016/j.ejca.2019.07.027 · Cited by 86 · see citing works
Szymanski, J. J., Sundby, R. T., Jones, P. A., Srihari, D., Earland, N. J., Harris, P. K. W., Feng, W., Qaium, F., Lei, H., Roberts, D., et al. (2021) · PLoS Medicine · doi:10.1371/journal.pmed.1003734 · Cited by 86 · see citing works
Wang, R., Lu, Y., Fisher, C., et al. (2001) · Genes Chromosomes and Cancer · doi:10.1002/gcc.1118 · Cited by 63 · see citing works
Detection of Circulating Tumor DNA in Patients With Leiomyosarcoma With Progressive Disease
Hemming, M. L., Klega, K. S., Rhoades, J., Ha, G., Acker, K. E., Andersen, J. L., Thai, E., Nag, A., Thorner, A. R., Raut, C. P., et al. (2019) · JCO Precision Oncology · doi:10.1200/po.18.00235 · Cited by 60 · see citing works
RNA-Sequencing of Tumor-Educated Platelets, a Novel Biomarker for Blood-Based Sarcoma Diagnostics
Heinhuis, K. M., Veld, S. G. J. G. I. ‘., Dwarshuis, G., van den Broek, D. A., Sol, N., Best, M. G., van Coevorden, F., Haas, R. L., Beijnen, J. H., van Houdt, W. J., et al. (2020) · Cancers · doi:10.3390/cancers12061372 · Cited by 58 · see citing works
Serrano, C., Vivancos, A. P., Pousa, A. L., Matito, J., Mancuso, F. M., Valverde, C. M., Quiroga, S., Landolfi, S., Castro, S., Dopazo, C., et al. (2020) · BMC Cancer · doi:10.1186/s12885-020-6597-x · Cited by 54 · see citing works
SERS and MALDI-TOF MS based plasma exosome profiling for rapid detection of osteosarcoma
Han, Z., Yi, J., Yang, Y., Li, D., Peng, C., Long, S., Peng, X., Shen, Y., Liu, B., & Qiao, L. (2021) · The Analyst · doi:10.1039/d1an01163d · Cited by 52 · see citing works
Yu, M., Wan, Y., & Zou, Q. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.06.007 · Cited by 48 · see citing works
Bauer, S., Heinrich, M. C., George, S., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-1864 · Cited by 46 · see citing works
Detection of circulating tumor cells in liquid biopsy from Ewing sarcoma patients
Benini, S., Gamberi, G., Cocchi, S., Garbetta, J., Alberti, L., Righi, A., Gambarotti, M., Picci, P., & Ferrari, S. M. (2018) · Cancer Management and Research · doi:10.2147/cmar.s141623 · Cited by 42 · see citing works
Genotyping of circulating cell-free DNA enables noninvasive tumor detection in myxoid liposarcomas
Braig, D., Becherer, C., Bickert, C., Braig, M., Claus, R., Eisenhardt, A. E., Heinz, J., Scholber, J., Herget, G. W., Bronsert, P., et al. (2019) · International Journal of Cancer · doi:10.1002/ijc.32216 · Cited by 42 · see citing works
Shah, A. T., Azad, T. D., Breese, M. R., Chabon, J. J., Hamilton, E. G., Straessler, K., Kurtz, D. M., Leung, S. G., Spillinger, A., Liu, H.-Y., et al. (2021) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-20-0987 · Cited by 42 · see citing works
Samuel, G., Crow, J., Klein, J. B., Merchant, M. L., Nissen, E., Koestler, D. C., Laurence, K., Liang, X., Neville, K. A., Staggs, V. S., et al. (2020) · Oncotarget · doi:10.18632/oncotarget.27678 · Cited by 41 · see citing works
Bao, Q., Gong, L., Wang, J., Wen, J., Shen, Y., & Zhang, W. (2018) · Annals of Surgical Oncology · doi:10.1245/s10434-018-6642-z · Cited by 40 · see citing works
Krumbholz, M., Eiblwieser, J., Ranft, A., Zierk, J., Schmidkonz, C., Stütz, A. M., Peneder, P., Tomazou, E. M., Agaimy, A., Bäuerle, T., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-1324 · Cited by 39 · see citing works
Gutteridge, A., Rathbone, V. M., Gibbons, R., Bi, M., Archard, N., Davies, K. E. J., Brown, J., Plagnol, V., Pillay, N., Amary, F., et al. (2017) · Cancer Medicine · doi:10.1002/cam4.1146 · Cited by 38 · see citing works
Ferreira, E. N., Barros, B. D. D. F., de Souza, J. E., de Almeida, R. V. B., Torrezan, G. T., Garcia, S., Krepischi, A. C. V., de Mello, C. A. L., da Cunha, I. W., Pinto, C. A. L., et al. (2016) · Human Genomics · doi:10.1186/s40246-016-0092-0 · Cited by 36 · see citing works
Precision diagnostics of Ewing’s sarcoma by liquid biopsy: circulating EWS-FLI1 fusion transcripts
Allegretti, M., Casini, B., Mandoj, C., Benini, S., Alberti, L., Novello, M., Melucci, E., Conti, L., Covello, R., Pescarmona, E. O., et al. (2018) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835918774337 · Cited by 36 · see citing works
Circulating cKIT and PDGFRA DNA indicates disease activity in Gastrointestinal Stromal Tumor (GIST)
Jilg, S., Rassner, M. P., Maier, J., Waldeck, S., Kehl, V., Follo, M., Philipp, U., Sauter, A. P., Specht, K., Mitschke, J., et al. (2019) · International Journal of Cancer · doi:10.1002/ijc.32282 · Cited by 36 · see citing works
Serum microRNA profile enables preoperative diagnosis of uterine leiomyosarcoma
Yokoi, A., Matsuzaki, J., Yamamoto, Y., et al. (2019) · Cancer Science · doi:10.1111/cas.14215 · Cited by 35 · see citing works
Wang, J., Guo, W., Wang, X., Tang, X., Sun, X., & Ren, T. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-2682 · Cited by 35 · see citing works
Fricke, A., Cimniak, A. F. V., Ullrich, P. V., Becherer, C., Bickert, C., Pfeifer, D., Heinz, J., Stark, G. B., Bannasch, H., Braig, D., et al. (2018) · Cancer Biomarkers · doi:10.3233/cbm-170496 · Cited by 33 · see citing works
imPlatelet classifier: image‐converted RNA biomarker profiles enable blood‐based cancer diagnostics
Pastuszak, K., Supernat, A. M., Best, M. G., Veld, S. G. J. G. I. ‘., Łapińska‐Szumczyk, S., Łojkowska, A., Różański, R., Zaczek, A. J., Jassem, J., Wurdinger, T. D., et al. (2021) · Molecular Oncology · doi:10.1002/1878-0261.13014 · Cited by 33 · see citing works
Han, Z., Peng, C., Yi, J., Wang, Y., Liu, Q., Yang, Y., Long, S., Qiao, L., & Shen, Y. (2021) · iScience · doi:10.1016/j.isci.2021.102906 · Cited by 32 · see citing works
Eguchi‐Ishimae, M., Tezuka, M., Kokeguchi, T., Nagai, K., Moritani, K., Yonezawa, S., Tauchi, H., Tokuda, K., Ishida, Y., Ishii, E., et al. (2019) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22734 · Cited by 30 · see citing works
de Vos, L., Jung, M., Koerber, R.-M., Bawden, E., Holderried, T. A. W., Dietrich, J., Bootz, F., Brossart, P., Kristiansen, G., & Dietrich, D. (2020) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2020.04.205 · Cited by 30 · see citing works
Schmidkonz, C., Krumbholz, M., Atzinger, A., Cordes, M., Goetz, T. I., Prante, O., Ritt, P., Schaefer, C., Agaimy, A., Hartmann, W., et al. (2019) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-019-04649-1 · Cited by 29 · see citing works
Zhang, H., Gao, P., Xiao, X., Heger, M., Geng, L., Fan, B., Yuan, Y., Huang, C., Chen, G., Liu, Y., et al. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.3905 · Cited by 28 · see citing works
Paemel, R. V., Vandeputte, C., Raman, L., Thorre, J. V., Willems, L., Dorpe, J. V., Linden, M. V. D., Wilde, J. D., Koker, A. D., Menten, B., et al. (2021) · European Journal of Cancer · doi:10.1016/j.ejca.2021.09.022 · Cited by 28 · see citing works
Mattox, A. K., Douville, C., Silliman, N., et al. (2022) · eLife · doi:10.7554/elife.74238 · Cited by 26 · see citing works
Cell-Free DNA as a Diagnostic and Prognostic Biomarker in Pediatric Rhabdomyosarcoma
Lak, N. S. M., van Zogchel, L. M. J., Zappeij-Kannegieter, L., Javadi, A., van Paemel, R., Vandeputte, C., De Preter, K., De Wilde, B., Chicard, M., Iddir, Y., et al. (2023) · JCO Precision Oncology · doi:10.1200/po.22.00113 · Cited by 25 · see citing works
Morita, T., Fujiwara, T., Yoshida, A., Uotani, K., Kiyono, M., Yokoo, S., Hasei, J., Kunisada, T., & Ozaki, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-66120-8 · Cited by 24 · see citing works
Seidel, M. G., Kashofer, K., Moser, T., Thueringer, A., Liegl-Atzwanger, B., Leithner, A., Szkandera, J., Benesch, M., El-Heliebi, A., & Heitzer, E. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.926405 · Cited by 24 · see citing works
Self-citationRuhen, O., Lak, N. S. M., Stutterheim, J., Danielli, S. G., Chicard, M., Iddir, Y., Saint‐Charles, A., Paolo, V. D., Tombolan, L., Gatz, S. A., et al. (2022) · JCO Precision Oncology · doi:10.1200/po.21.00534 · Cited by 24 · see citing works
Use of liquid biopsies to monitor disease progression in a sarcoma patient: a case report
Namløs, H. M., Zaikova, O., Bjerkehagen, B., Vodák, D., Hovig, E. J., Myklebost, O., Boye, K., & Meza‐Zepeda, L. A. (2017) · BMC Cancer · doi:10.1186/s12885-016-2992-8 · Cited by 23 · see citing works
Detection of fusion gene in cell-free DNA of a gastric synovial sarcoma
Ogino, S., Konishi, H., Ichikawa, D., Hamada, J., Shoda, K., Arita, T., Komatsu, S., Shiozaki, A., Okamoto, K. K., Yamazaki, S., et al. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i8.949 · Cited by 23 · see citing works
Clinical significance of circulating tumor cells and cell‐free DNA in pediatric rhabdomyosarcoma
Tombolan, L., Rossi, E. M. C., Binatti, A., Zin, A., Manicone, M., Facchinetti, A., Lucchetta, S., Affinita, M. C., Bonvini, P., Bortoluzzi, S., et al. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13197 · Cited by 23 · see citing works
Connell, L. M., Gazdová, J., Beck, K., Srivastava, S., Harewood, L., Stewart, P., Hübschmann, D., Stenzinger, A., Glimm, H., Heilig, C. E., et al. (2020) · Cancers · doi:10.3390/cancers12123627 · Cited by 22 · see citing works
Madanat‐Harjuoja, L. M., Klega, K. S., Lu, Y., Shulman, D. S., Thorner, A. R., Nag, A., Tap, W. D., Reinke, D. K., Diller, L., Ballman, K. V., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-3951 · Cited by 21 · see citing works
Colletti, M., Paolini, A., Galardi, A., Paolo, V. D., Pascucci, L., Russo, I., Angelis, B. D., Peinado, H., Vito, R. D., Milano, G. M., et al. (2018) · Epigenomics · doi:10.2217/epi-2018-0179 · Cited by 20 · see citing works
Comprehensive serum and tissue microRNA profiling in dedifferentiated liposarcoma
Kohama, I., Asano, N., Matsuzaki, J., Yamamoto, Y., Yamamoto, T., Takahashi, R., Kobayashi, E., Takizawa, S., Sakamoto, H., Kato, K., et al. (2021) · Oncology Letters · doi:10.3892/ol.2021.12884 · Cited by 19 · see citing works
Stegmaier, S., Sparber‐Sauer, M., Aakcha‐Rudel, E., Münch, P., Reeh, T., Feuchtgruber, S., Hallmen, E., Blattmann, C., Bielack, S., Klingebiel, T. E., et al. (2022) · Pediatric Blood & Cancer · doi:10.1002/pbc.29652 · Cited by 19 · see citing works
Crow, J., Samuel, G., Farrow, E., Gibson, M., Johnston, J. J., Guest, E. M., Miller, N., Pei, D., Koestler, D. C., Pathak, H. B., et al. (2022) · Biomarker Insights · doi:10.1177/11772719221132693 · Cited by 19 · see citing works
Demoret, B., Gregg, J., Liebner, D. A., Tinoco, G., Lenobel, S., & Chen, J. L. (2019) · Cancers · doi:10.3390/cancers11121829 · Cited by 18 · see citing works
The Circulating Nucleic Acid Characteristics of Non-Metastatic Soft Tissue Sarcoma Patients
Eastley, N. C., Sommer, A., Ottolini, B., Neumann, R., Luo, J., Hastings, R. K., McCulloch, T. A., Esler, C. P., Shaw, J., Ashford, R. U., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124483 · Cited by 18 · see citing works
Johansson, G., Berndsen, M., Lindskog, S., Österlund, T., Fagman, H., Muth, A., & Ståhlberg, A. (2021) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-21-0403 · Cited by 18 · see citing works
Genotyping of Circulating Free DNA Enables Monitoring of Tumor Dynamics in Synovial Sarcomas
Eisenhardt, A. E., Brugger, Z., Lausch, U., Kiefer, J., Zeller, J., Runkel, A., Schmid, A., Bronsert, P., Wehrle, J., Leithner, A., et al. (2022) · Cancers · doi:10.3390/cancers14092078 · Cited by 18 · see citing works
Self-citationXiang, H., Wang, J., Hisaoka, M., et al. (2008) · Pathology · doi:10.1080/00313020802320424 · Cited by 17 · see citing works
Mihály, D., Nagy, N., Papp, G., Pápai, Z., & Sápi, Z. (2018) · Diagnostic Pathology · doi:10.1186/s13000-018-0756-2 · Cited by 17 · see citing works
Lyskjær, I., Davies, C., Strobl, A., Hindley, J., James, S., Lalam, R. K., Cross, W., Hide, G., Rankin, K. S., Jeys, L., et al. (2021) · Molecular Oncology · doi:10.1002/1878-0261.13102 · Cited by 16 · see citing works
Przybył, J., van de Rijn, M., & Rutkowski, P. L. (2019) · Diagnostic Pathology · doi:10.1186/s13000-019-0800-x · Cited by 15 · see citing works
Long Noncoding MT1JP Enhanced the Inhibitory Effects of miR-646 on FGF2 in Osteosarcoma
Yang, L., Liu, G., Xiao, S., et al. (2020) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1089/cbr.2019.3328 · Cited by 15 · see citing works
Yokoo, S., Fujiwara, T., Yoshida, A., Uotani, K., Morita, T., Kiyono, M., Hasei, J., Nakata, E., Kunisada, T., Iwata, S., et al. (2021) · Cancers · doi:10.3390/cancers13081823 · Cited by 14 · see citing works
Lee, S., Lim, S., & Cho, D. H. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6323 · Cited by 13 · see citing works
Circulating Plasma Tumor DNA Is Superior to Plasma Tumor RNA Detection in Ewing Sarcoma Patients
Bodlak, A., Chang, K., Channel, J., Treece, A. L., Donaldson, N., Cost, C. R., Garrington, T. P., Greffe, B., Luna-Fineman, S., Sopfe, J., et al. (2021) · The Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2021.04.003 · Cited by 12 · see citing works
Increased expression of microRNA-26a-5p predicted a poor survival outcome in osteosarcoma patients
Xie, X., Chen, X.-M., Shi, L., & Liu, J. (2021) · Medicine · doi:10.1097/md.0000000000024765 · Cited by 11 · see citing works
Cahn, F., Revon‐Rivière, G., Min, V., Rome, A., Filaine, P., Pelletier, A., Abed, S., Gentet, J.-C., Verschuur, A. C., & André, N. (2022) · Cancers · doi:10.3390/cancers14112774 · Cited by 10 · see citing works
Przybył, J., Spans, L., Ganjoo, K. N., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262272 · Cited by 6 · see citing works
Individualized Mini-Panel Sequencing of ctDNA Allows Tumor Monitoring in Complex Karyotype Sarcomas
Braig, D., Runkel, A., Eisenhardt, A. E., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810215 · Cited by 6 · see citing works
Rapid and highly sensitive approach for multiplexed somatic fusion detection
Abbou, S. D., Finstuen-Magro, S., McDannell, B., Feenstra, M., Ward, A., Shulman, D. S., Geoerger, B., Duplan, J., Comeau, H., Janeway, K. A., et al. (2022) · Modern Pathology · doi:10.1038/s41379-022-01058-y · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [8]Group OLoEW (2011) The Oxford 2011 levels of evidence. Oxford Centre for Evidence-Based Medicine, Oxford
- [25]Shukla NN, Patel JA, Magnan H, Zehir A, You D, Tang J et al (2017) Plasma DNA-based molecular diagnosis, prognostication, and monitoring of patients with EWSR1 fusion-positive sarcomas. JCO Precis Oncol 2017:1–11 PMC5881916 29629425
Cited by
Sorted by citations
Alabid, I., Yousef, A. J., Patni, M. M., Aloti, R. A., Qassim, Z. A.-A. M., Alothman-Agha, A. A., Hamdy, H. A., Noury, F. M., & Abdelfattah, M. T. (2026) · Cells · doi:10.3390/cells15141271
- Authors
- Smolle, M. A., Seidel, M. G., Kashofer, K., Liegl-Atzwanger, B., Sadoghi, P., Müller, D. A., & Leithner, A.
- Affiliations
- Medical University of Graz (AT)
- University of Zurich (CH)
- Corresponding author
- Leithner, Andreas
- Venue
- Archives of Orthopaedic and Trauma Surgery
- Published
- 2025-01-11
- Volume
- 145
- Issue
- 1
- Pages
- 121-121
- ISSN
- 0936-8051 (ISSN-L)
- 1434-3916
- PMC
- PMC11724793
- OpenAlex
- W4406274630
- Cited by
- 16
- References
- 83
- Citations by year
- 2026: 16
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Archives of Orthopaedic and Trauma Surgery (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by)
- Funders
- Medical University of Graz
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Rheumatology › Bone Tumor Diagnosis and Treatments
- Keywords
- liquid biopsy, bone and soft tissue sarcoma, osteosarcoma, Ewing sarcoma, gastrointestinal stromal tumor, rhabdomyosarcoma, leiomyosarcoma, circulating tumor DNA, cell-free DNA, disease surveillance, prognosis, diagnosis
- MeSH terms
- Liquid Biopsy, Bone Neoplasms, Humans, Prognosis, Sarcoma, Osteosarcoma, Soft Tissue Neoplasms, Biomarkers, Tumor, Precision Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
