The role of androgen and androgen receptor in skin-related disorders
Open accessAbstract
Androgen and androgen receptor (AR) may play important roles in several skin-related diseases, such as androgenetic alopecia and acne vulgaris. Current treatments for these androgen/AR-involved diseases, which target the synthesis of androgens or prevent its binding to AR, can cause significant adverse side effects. Based on the recent studies using AR knockout mice, it has been suggested that AR and androgens play distinct roles in the skin pathogenesis, and AR seems to be a better target than androgens for the treatment of these skin diseases. Here, we review recent studies of androgen/AR roles in several skin-related disorders, including acne vulgaris, androgenetic alopecia and hirsutism, as well as cutaneous wound healing.
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5αR2 is detected in genital skin fibroblasts and IRSKs.
“5αR2 is detected in genital skin fibroblasts and IRSKs [107].”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [107]
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Steroidogenesis in the skin: Implications for local immune functions
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Skin steroidogenesis in health and disease
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- Authors
- Lai, J.-J., Chang, P., Lai, K.-P., Chen, L., & Chang, C.
- Affiliations
- University of Rochester Medicine (US)
- China Medical University (TW)
- Corresponding author
- Chang, Chawnshang
- Venue
- Archives of Dermatological Research
- Published
- 2012-07-25
- Volume
- 304
- Issue
- 7
- Pages
- 499-510
- ISSN
- 0003-9187 (ISSN-L)
- 0340-3696
- 1432-069X
- PMC
- PMC3763909
- OpenAlex
- W2062665729
- Cited by
- 207
- References
- 129
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 37 · 2023: 15 · 2022: 17 · 2021: 24 · 2020: 25 · 2019: 12 · 2018: 9 · 2017: 13 · 2016: 11 · 2015: 10 · 2014: 7 · 2013: 6 · 2012: 1
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Dermatological Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK073414, DK-73414)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Keywords
- androgen receptor, androgens, skin diseases, acne, androgenetic alopecia, hirsutism, skin wound healing, androgen receptor knockout mice, androgen synthesis inhibitors
- MeSH terms
- Acne Vulgaris, Alopecia, Androgen Antagonists, Androgens, Animals, Hirsutism, Humans, Receptors, Androgen, Wound Healing, Mice, Knockout, Mice, Molecular Targeted Therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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