Biosynthesis of dihydrotestosterone by a pathway that does not require testosterone as an intermediate in the SZ95 sebaceous gland cell line
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DHT formation in SZ95 sebocytes does not always require testosterone as an intermediate; an alternative pathway is 5α-reduction of androstenedione to 5α-androstanedione followed by conversion to DHT by 17βHSD.
“The formation of DHT in SZ95 sebocytes does not always require T as an intermediate, since 5α-reduction of androstenedione to 5α-androstanedione and subsequent conversion to DHT by 17βHSD provides an alternative pathway [110].”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [110]
The conversion of A4 to DHT proceeds via the 5α-reduction of A4 to 5α-androstanedione, followed by the conversion of 5α-dione to DHT.
“Indeed, the conversion of A4 (Δ4, 17-keto) to DHT (5α, 17β) proceeds via the 5α-reduction of A4 to 5α-androstanedione (5α-dione, 5α-androstane-3,17-dione), followed by the conversion of 5α-dione to DHT (Chang et al., 2011' Luu-The and Labrie, 2010, Samson et al., 2010) (Fig. 6).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Samson et al., 2010
The presence of SRD5A1 allows for local production of DHT, with the 5α-dione pathway bypassing T being the preferred route.
“The presence of SRD5A1 allows for the local production of DHT (Luu-The et al., 1994), with the 5α-dione pathway bypassing T being the preferred route (Samson et al., 2010, Sugimoto et al., 1995) (Fig. 6).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Samson et al., 2010
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Steroidogenesis in the skin: Implications for local immune functions
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Testosterone synthesis in patients with 17β-hydroxysteroid dehydrogenase 3 deficiency
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- Authors
- Samson, M., Labrie, F., Zouboulis, C. C., & Luu-The, V.
- Affiliations
- Centre hospitalier de l'Université Laval (CA)
- Städtisches Klinikum Dessau (DE)
- Corresponding author
- Luu-The, Van
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 130
- Issue
- 2
- Pages
- 602-604
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W1985371586
- Cited by
- 42
- References
- 26
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 4 · 2014: 6 · 2013: 5 · 2012: 3
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Université Laval
- Canadian Institutes of Health Research (53894_1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- sebaceous glands, 17β-hydroxysteroid dehydrogenase, 3β-hydroxysteroid dehydrogenase, 5α-reductase, androstenedione, dehydroepiandrosterone, testosterone, sex steroid metabolism
- MeSH terms
- Cell Line, Humans, Models, Biological, RNA, Messenger, Sebaceous Glands, Dihydrotestosterone, Testosterone, Inhibitory Concentration 50
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