The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
Role of AhR/ARNT system in skin homeostasis
Open accessAbstract
Aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that binds to structurally diverse synthetic and naturally occurring chemicals including dioxins, flavonoids, tryptophan photoproducts, and Malassezia metabolites. Upon binding to its ligands, cytoplasmic AhR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT), and mediates numerous biological and toxicological effects by inducing the transcription of various AhR-responsive genes. AhR ligation controls oxidation/antioxidation, epidermal barrier function, photo-induced response, melanogenesis, and innate immunity. This review summarizes recent advances in the understanding of the regulatory mechanisms of skin homeostasis mediated by the AhR/ARNT system.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
![Fig. 2 AhR ligation induces not only oxidative stress but also antioxidative response in a ligand-dependent manner. Environmental pollutants such as benzo[a]pyrene and TCDD bind to AhR and induce ROS production, DNA damage, and inflammatory cytokine production. In contrast, ketoconazole and certain flavonoids bind to AhR, resulting in the activation of Nrf2 and subsequent induction of antioxidative enzymes such as Nqo1. These antioxidative enzymes inhibit ROS production, DNA damage, and inflammatory cytokine production. Thus, AhR acts as a master switch for oxidation and antioxidation](/paper-figures/0c747253840d4fd5b4aa5798310f85e8/role-of-ahr-arnt-system-in-skin-homeostasis-figure-2.jpg)
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Air pollutants contain various exogenous ligands with high affinities for AhR, including PAHs and halogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzodioxin (TCDD), dimethylbenz[a]anthracene, methylcholanthrene, and benzo[a]pyrene (BaP)30.”
From Air Pollution and Skin Diseases (2025) · cites this paper as [30]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The ligand/AHR complex then binds to specific DNA recognition sites, namely, xenobiotic-responsive elements or dioxin-responsive elements, and upregulates the transcription of a series of responsive genes, such as CYP1A1 leading to a robust generation of reactive oxygen species [16,24].”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [16]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“AHR is a xenobiotic chemical sensor that is expressed abundantly in epidermal keratinocytes [15,16].”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [16]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“The AhR is widely expressed in the skin, and is important in maintaining skin integrity and immune functions30.”
From Air Pollution and Skin Diseases (2025) · cites this paper as [30]
The cited source says what the claim attributes to it.
In the citing paper
“Various external and internal ligands, such as dioxins, polycyclic aromatic pollutants, benzo[a]pyrene, and phytochemicals, can bind to and activate AHR [15,16].”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [16]
The cited source says what the claim attributes to it.
In the citing paper
“Various herbal and antioxidant phytochemicals have been shown to activate AHR [16,17,19].”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [16]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor
Quintana, F. J., Basso, A. S., Iglesias, A. H., Korn, T., Farez, M. F., Bettelli, E., Caccamo, M., Oukka, M., & Weiner, H. L. (2008) · Nature · doi:10.1038/nature06880 · Cited by 1,865
The Aryl Hydrocarbon Receptor Complex
Hankinson, O. (1995) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.001515 · Cited by 1,649 · cited 2×
“The translocated HSP90bound AhR subsequently dissociates from the HSP90 complex by binding to a structurally related nuclear protein, aryl hydrocarbon receptor nuclear translocator (ARNT) [22].”
BackgroundThe aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
Veldhoen, M., Hirota, K., Westendorf, A. M., Buer, J., Dumoutier, L., Renauld, J.-C., & Stockinger, B. (2008) · Nature · doi:10.1038/nature06881 · Cited by 1,634
Nrf2 signaling in coordinated activation of antioxidant gene expression
Jaiswal, A. K. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.02.074 · Cited by 1,263
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
Wakabayashi, N., Itoh, K., Wakabayashi, J., Motohashi, H., Noda, S., Takahashi, S., Imakado, S., KOTSUJI, T., Otsuka, F., Roop, D. R., et al. (2003) · Nature Genetics · doi:10.1038/ng1248 · Cited by 881
Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation
Li, Y., Innocentin, S., Withers, D. R., Roberts, N. A., Gallagher, A., Grigorieva, E. F., Wilhelm, C., & Veldhoen, M. (2011) · Cell · doi:10.1016/j.cell.2011.09.025 · Cited by 837
Functional role of AhR in the expression of toxic effects by TCDD
Mimura, J., & Fujii‐Kuriyama, Y. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00485-3 · Cited by 754
Denison, M. S., Soshilov, A. A., He, G., DeGroot, D. E., & Zhao, B. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr218 · Cited by 748
The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor
Nguyen, L. P., & Bradfield, C. A. (2007) · Chemical Research in Toxicology · doi:10.1021/tx7001965 · Cited by 718
Nguyen, N. T., Kimura, A., Nakahama, T., Chinen, I., Masuda, K., Nohara, K., Fujii‐Kuriyama, Y., & Kishimoto, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014465107 · Cited by 705
Cited by
Sorted by citations
Natividad, J. M., Agus, A., Planchais, J., Lamas, B., Jarry, A. C., Martin, R., Michel, M.-L., Chong-Nguyen, C., Roussel, R., Straube, M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.001 · Cited by 642
Aryl hydrocarbon receptor and intestinal immunity
Lamas, B., Natividad, J. M., & Sokol, H. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0019-2 · Cited by 551
Furue, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155382 · Cited by 419
Self-citationUberoi, A., Bartow‐McKenney, C., Zheng, Q., Flowers, L. J., Campbell, A. E., Knight, S. A. B., Chan, N., Wei, M. H., Lovins, V. M., Bugayev, J., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.05.011 · Cited by 328
Oxidative Stress in Atopic Dermatitis
Ji, H., & Li, X. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2721469 · Cited by 218
Metadata
- Authors
- Furue, M., Takahara, M., Nakahara, T., & Uchi, H.
- Affiliations
- Kyushu University (JP)
- Corresponding author
- Furue, Masutaka
- Venue
- Archives of Dermatological Research
- Published
- 2014-06-26
- Volume
- 306
- Issue
- 9
- Pages
- 769-779
- ISSN
- 0003-9187 (ISSN-L)
- 0340-3696
- 1432-069X
- PMC
- PMC4220966
- OpenAlex
- W1991467319
- Cited by
- 175
- References
- 97
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 14 · 2023: 18 · 2022: 20 · 2021: 17 · 2020: 21 · 2019: 18 · 2018: 22 · 2017: 14 · 2016: 4 · 2015: 9 · 2014: 2
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Archives of Dermatological Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- aryl hydrocarbon receptor, ARNT, skin homeostasis, dioxins, flavonoids, tryptophan photoproducts, skin barrier function, melanogenesis, innate immunity, oxidative stress, transcriptional regulation, xenobiotic toxicity
- MeSH terms
- Animals, Gene Expression Regulation, Homeostasis, Humans, Immunity, Innate, Ligands, Melanins, Permeability, Skin, Skin Diseases, Signal Transduction, Receptors, Aryl Hydrocarbon, Oxidative Stress, Aryl Hydrocarbon Receptor Nuclear Translocator
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
