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Role of AhR/ARNT system in skin homeostasis
Open accessAbstract
Aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that binds to structurally diverse synthetic and naturally occurring chemicals including dioxins, flavonoids, tryptophan photoproducts, and Malassezia metabolites. Upon binding to its ligands, cytoplasmic AhR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT), and mediates numerous biological and toxicological effects by inducing the transcription of various AhR-responsive genes. AhR ligation controls oxidation/antioxidation, epidermal barrier function, photo-induced response, melanogenesis, and innate immunity. This review summarizes recent advances in the understanding of the regulatory mechanisms of skin homeostasis mediated by the AhR/ARNT system.
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“Air pollutants contain various exogenous ligands with high affinities for AhR, including PAHs and halogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzodioxin (TCDD), dimethylbenz[a]anthracene, methylcholanthrene, and benzo[a]pyrene (BaP)30.”
From Air Pollution and Skin Diseases (2025) · cites this paper as [30]
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“The ligand/AHR complex then binds to specific DNA recognition sites, namely, xenobiotic-responsive elements or dioxin-responsive elements, and upregulates the transcription of a series of responsive genes, such as CYP1A1 leading to a robust generation of reactive oxygen species [16,24].”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [16]
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“AHR is a xenobiotic chemical sensor that is expressed abundantly in epidermal keratinocytes [15,16].”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [16]
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“The AhR is widely expressed in the skin, and is important in maintaining skin integrity and immune functions30.”
From Air Pollution and Skin Diseases (2025) · cites this paper as [30]
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“Various external and internal ligands, such as dioxins, polycyclic aromatic pollutants, benzo[a]pyrene, and phytochemicals, can bind to and activate AHR [15,16].”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [16]
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“Various herbal and antioxidant phytochemicals have been shown to activate AHR [16,17,19].”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [16]
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Self-citation
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Metadata
- Authors
- Furue, M., Takahara, M., Nakahara, T., & Uchi, H.
- Affiliations
- Kyushu University (JP)
- Corresponding author
- Furue, Masutaka
- Venue
- Archives of Dermatological Research
- Published
- 2014-06-26
- Volume
- 306
- Issue
- 9
- Pages
- 769-779
- ISSN
- 0003-9187 (ISSN-L)
- 0340-3696
- 1432-069X
- PMC
- PMC4220966
- OpenAlex
- W1991467319
- Cited by
- 175
- References
- 97
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 14 · 2023: 18 · 2022: 20 · 2021: 17 · 2020: 21 · 2019: 18 · 2018: 22 · 2017: 14 · 2016: 4 · 2015: 9 · 2014: 2
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Archives of Dermatological Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- aryl hydrocarbon receptor, ARNT, skin homeostasis, dioxins, flavonoids, tryptophan photoproducts, skin barrier function, melanogenesis, innate immunity, oxidative stress, transcriptional regulation, xenobiotic toxicity
- MeSH terms
- Animals, Gene Expression Regulation, Homeostasis, Humans, Immunity, Innate, Ligands, Melanins, Permeability, Skin, Skin Diseases, Signal Transduction, Receptors, Aryl Hydrocarbon, Oxidative Stress, Aryl Hydrocarbon Receptor Nuclear Translocator
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