Diagnosis of endometrial nerve fibers in women with endometriosis
Abstract
Purpose Recent studies indicated that there is a high density of small nerve fibers in the functional layer of the endometrium in women with endometriosis and that it can be used as a marker to detect endometriosis. In this study, the efficacy assessment of small nerve fibers' density as a diagnostic marker was compared in patients with and without endometriosis.Methods In this study, women with history of pelvic pain and/or infertility who were candidates for laparoscopy or laparotomy in Rassoul hospital (2007-2009) were enrolled. Histological sections of endometrial tissue were prepared from endometrial biopsy from women with endometriosis (n = 12) (1) and without endometriosis (n = 15) (2). Protein gene product 9.5 and neurofilament were evaluated as marker from endometrial biopsies by immunohistochemical methods.Results There was no statistically significant difference between two groups according to age, body mass index. Nerve fibers were detected in all endometrial biopsies from all women with endometriosis but detected only in three women without endometriosis. The mean density of nerve fibers was 2.2 ± 4.7 mm(-2) in group without endometriosis and) 13.1 ± 3.3 (in group with endometriosis (p < 0.001). Women with endometriosis had significantly higher nerve fiber density in comparison with women without endometriosis.Conclusions Our findings indicated that endometrial biopsy for detecting density of nerve fibers by usage of protein gene product 9.5, provided a reliable marker for diagnosis of endometriosis.
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These results were confirmed in a study of 27 prospectively collected eutopic endometrial specimens using identical sampling and detection methods.
“These results were confirmed in a study of 27 prospectively collected eutopic endometrial specimens using identical sampling and detection methods [142].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [142]
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- Authors
- Aghaey Meibody, F., Mehdizadeh Kashi, A., Zare Mirzaie, A., Ghajarie Bani Amam, M., Shariati Behbahani, A., Zolali, B., & Najafi, L.
- Affiliations
- Iran University of Medical Sciences (IR)
- Corresponding author
- Najafi, Laily
- ORCID
- Najafi, Laily
- Venue
- Archives of Gynecology and Obstetrics
- Published
- 2010-12-17
- Volume
- 284
- Issue
- 5
- Pages
- 1157-1162
- ISSN
- 0003-9128 (ISSN-L)
- 0932-0067
- 1432-0711
- OpenAlex
- W1964378623
- Cited by
- 35
- References
- 24
- Citations by year
- 2026: 3 · 2024: 2 · 2021: 3 · 2019: 4 · 2018: 1 · 2016: 3 · 2015: 5 · 2014: 4 · 2013: 6 · 2012: 3
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Gynecology and Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, small nerve fibers, nerve fiber density, protein gene product 9.5, neurofilaments, endometrial biopsy, diagnostic biomarkers, pelvic pain, infertility
- MeSH terms
- Adolescent, Adult, Biopsy, Endometriosis, Endometrium, Female, Humans, Infertility, Female, Middle Aged, Nerve Fibers, Prospective Studies, Biomarkers, Neurofilament Proteins, Pelvic Pain, Ubiquitin Thiolesterase, Young Adult
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