Endometriosis-associated nerve fibers and pain.
Open accessAbstract
The assessment and diagnosis of endometriosis remain elusive targets. Patient and medical-related factors add to delays in the detection and treatment. Recently, investigators have revealed specific nerve fibers present in endometriotic tissue, with existing parallels between density and pain severity. The aim of this review is to compile a comprehensive review of existing literature on endometriosis-related nerve fiber detection, and the effects of medical therapy on these neural fibers. We performed a systematic literature-based review using Medline and PubMed of nerve fibers detected in eutopic endometrium, endometriotic lesions, and the peritoneum. Various arrangements of significant medical terms and phrases consisting of endometriosis, pelvic pain, nerve fiber detection/density in endometriosis, and diagnoses methodology, including treatment and detection were applied in the search. Subsequent references used were cross-matched with existing sources to compile all additional similar reports. Similar nerve fibers were detected within lesions, endometrium, and myometrium, though at varying degrees of density. Hormonal therapy is widely used to treat endometriosis and was shown to be related to a reduction in fiber density. A direct result of specific nerve fiber detection within eutopic endometrial layers points to the use of a minimally invasive endometrial biopsy technique in reducing delay in diagnosis and subsequent possible preservation of fertility.
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Hormonal therapy is related to a reduction in nerve fiber density in ectopic endometrial growths.
“Consistent with this possibility are recent findings from a comprehensive clinical review that hormonal therapy is related to a reduction in nerve fiber density in ectopic endometrial growths [37].”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [37]
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- Authors
- MEDINA, M. G., & LEBOVIC, D. I.
- Affiliations
- University of Michigan (US)
- University of Wisconsin–Madison (US)
- Corresponding author
- LEBOVIC, DAN I.
- Venue
- Acta Obstetricia Et Gynecologica Scandinavica
- Publisher
- Wiley
- Published
- 2009-09
- Volume
- 88
- Issue
- 9
- Pages
- 968-975
- ISSN
- 0001-6349 (ISSN-L)
- 1600-0412
- PMC
- PMC4554536
- OpenAlex
- W2108644400
- Cited by
- 63
- References
- 29
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 1 · 2021: 7 · 2020: 1 · 2019: 7 · 2018: 5 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 9
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Acta Obstetricia Et Gynecologica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5k23hd043952-02)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K23 HD043952, 5K23 HD 043952-02)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, nerve fibers, pelvic pain, endometriotic lesions, eutopic endometrium, myometrium, peritoneum, nerve fiber density, hormone therapy, endometrial biopsy, fertility preservation, endometriosis diagnosis
- MeSH terms
- Endometriosis, Endometrium, Female, Humans, Myometrium, Nerve Fibers, Pelvic Pain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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