A pilot study to evaluate the relative efficacy of endometrial biopsy and full curettage in making a diagnosis of endometriosis by the detection of endometrial nerve fibers
Abstract
Objective The purpose of this study was to evaluate endometrial biopsy and curettage in detecting small nerve fibers in eutopic endometrium for diagnosis of endometriosis. Study design Endometrial biopsies with precise, consistent technique and curettings were taken from 37 women (20 with endometriosis and 17 without endometriosis). Sensitivity, specificity, and positive and negative predictive value were formally calculated. Endometrial nerve fibers were immunohistochemically detected using the pan-neuronal marker PGP9.5. Results Small nerve fibers were detected in all endometrial biopsies and curettings from all 20 women with endometriosis, but were not detected in endometrium taken from 17 women without endometriosis. Mean (+/-SD) nerve fiber density in the endometrial biopsies was 26.8 per mm(2) +/- 55.9 (range, 1.6-125) and for curettings was 21.6 per mm(2) +/- 33.1 (range, 0.8-250), with 100% specificity, sensitivity, and positive and negative predictive value. Conclusion Careful endometrial biopsy combined with immunohistochemical staining for nerve fibers may be a reliable means of diagnosing or excluding endometriosis.
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Women with endometriosis who undergo endometrial biopsy or hysterectomy have more nerve fibers in the endometrium and myometrium than other women and than women with endometriosis using hormonal treatments.
“An increase of nerve fibers in the endometrium and myometrium was observed in women with endometriosis undergoing endometrial biopsy or hysterectomy compared with other women and women with endometriosis using hormonal treatments”
From Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications (2011) · cites this paper as Al-Jefout et al., 2007
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Tokushige, N., Markham, R., Russell, P., & Fraser, I. S. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.12.078 · Cited by 151 · see citing works
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Al-Jefout, M., Dezarnaulds, G., Cooper, M., Tokushige, N., Luscombe, G. M., Markham, R., & Fraser, I. S. (2009) · Human Reproduction · doi:10.1093/humrep/dep275 · Cited by 151 · see citing works
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Endometrial nerve fibers in women with endometriosis, adenomyosis, and uterine fibroids
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MEDINA, M. G., & LEBOVIC, D. I. (2009) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1080/00016340903176826 · Cited by 63 · see citing works
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Tokushige, N., Markham, R., Crossett, B., Ahn, S. B., Nelaturi, V. L., Khan, A., & Fraser, I. S. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.05.016 · Cited by 61 · see citing works
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Diagnosis of endometrial nerve fibers in women with endometriosis
Aghaey Meibody, F., Mehdizadeh Kashi, A., Zare Mirzaie, A., Ghajarie Bani Amam, M., Shariati Behbahani, A., Zolali, B., & Najafi, L. (2011) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-010-1806-5 · Cited by 35 · see citing works
- Authors
- Al-Jefout, M., Andreadis, N., Tokushige, N., Markham, R., & Fraser, I.
- Affiliations
- The University of Sydney (AU)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 197
- Issue
- 6
- Pages
- 578.e1-578.e4
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W1977140365
- Cited by
- 68
- References
- 1
- Citations by year
- 2023: 2 · 2022: 1 · 2020: 1 · 2019: 7 · 2018: 3 · 2016: 3 · 2015: 7 · 2014: 6 · 2013: 7 · 2012: 4
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- UCLA - Biblioteca de Ciencias de la Salud (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis diagnosis, endometrial biopsy, curettage, PGP 9.5, immunohistochemistry, nerve fiber density, sensitivity and specificity, eutopic endometrium
- MeSH terms
- Biopsy, Curettage, Endometriosis, Endometrium, Female, Humans, Pilot Projects, Treatment Outcome, Nerve Fibers, Unmyelinated
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