Thermal Detection Thresholds of Aδ- and C-Fibre Afferents Activated by Brief CO2 Laser Pulses Applied onto the Human Hairy Skin
Open accessAbstract
Brief high-power laser pulses applied onto the hairy skin of the distal end of a limb generate a double sensation related to the activation of Aδ- and C-fibres, referred to as first and second pain. However, neurophysiological and behavioural responses related to the activation of C-fibres can be studied reliably only if the concomitant activation of Aδ-fibres is avoided. Here, using a novel CO(2) laser stimulator able to deliver constant-temperature heat pulses through a feedback regulation of laser power by an online measurement of skin temperature at target site, combined with an adaptive staircase algorithm using reaction-time to distinguish between responses triggered by Aδ- and C-fibre input, we show that it is possible to estimate robustly and independently the thermal detection thresholds of Aδ-fibres (46.9±1.7°C) and C-fibres (39.8±1.7°C). Furthermore, we show that both thresholds are dependent on the skin temperature preceding and/or surrounding the test stimulus, indicating that the Aδ- and C-fibre afferents triggering the behavioural responses to brief laser pulses behave, at least partially, as detectors of a change in skin temperature rather than as pure level detectors. Most importantly, our results show that the difference in threshold between Aδ- and C-fibre afferents activated by brief laser pulses can be exploited to activate C-fibres selectively and reliably, provided that the rise in skin temperature generated by the laser stimulator is well-controlled. Our approach could constitute a tool to explore, in humans, the physiological and pathophysiological mechanisms involved in processing C- and Aδ-fibre input, respectively.
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The study aimed to maintain a dataset of at least N > 11, comparable to other LEP studies including drug LEP studies with N = 12.
“We aimed to maintain a dataset of at least N > 11 [comparable to other LEP studies 47, including studies using LEPs to investigate the analgesic properties of drugs 35: N = 12]”
From The Analgesic Effect of Oxytocin in Humans: A Double‐Blind, Placebo‐Controlled Cross‐Over Study Using Laser‐Evoked Potentials (2016) · cites this paper as [47]
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- Authors
- Churyukanov, M., Plaghki, L., Legrain, V., & Mouraux, A.
- Affiliations
- Sechenov University (RU)
- UCLouvain (BE)
- Ghent University (BE)
- Corresponding author
- Churyukanov, Maxim
- Plaghki, Léon
- Legrain, Valéry
- Mouraux, André
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-04-25
- Volume
- 7
- Issue
- 4
- Pages
- e35817
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3338467
- OpenAlex
- W2000907074
- Cited by
- 97
- References
- 36
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 9 · 2022: 3 · 2021: 8 · 2020: 13 · 2019: 8 · 2018: 5 · 2017: 13 · 2016: 7 · 2015: 8 · 2014: 6 · 2013: 7 · 2012: 2
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
- RePEc: Research Papers in Economics (submittedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- thermal detection threshold, A-delta fibers, C-fibers, CO2 laser pulses, hairy skin, reaction time, skin temperature
- MeSH terms
- Adult, Evoked Potentials, Somatosensory, Female, Hot Temperature, Humans, Male, Nerve Fibers, Myelinated, Nociceptors, Reaction Time, Skin, Skin Temperature, Pain Threshold, Nerve Fibers, Unmyelinated, Lasers, Gas
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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