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Proteoglycans: Structures And Interactions

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Impact of adolescent intermittent ethanol exposure on interneurons and their surrounding perineuronal nets in adulthood

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Activity-dependent remodeling of chondroitin sulfate proteoglycans extracellular matrix in the hypothalamo–neurohypophysial system

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3D Bioprinting of Glioblastoma Model

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Surfen, a proteoglycan binding agent, reduces inflammation but inhibits remyelination in murine models of Multiple Sclerosis

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Oligodendrocyte Myelin Glycoprotein Does Not Influence Node of Ranvier Structure or Assembly

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Erratum to: Anosmin-1 over-expression regulates oligodendrocyte precursor cell proliferation, migration and myelin sheath thickness

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Structural Abnormalities of Corpus Callosum and Cortical Axonal Tracts Accompanied by Decreased Anxiety-Like Behavior and Lowered Sociability in Spock3-Mutant Mice

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Hyaluronan degradation and release of a hyaluronan-aggrecan complex from perineuronal nets in the aged mouse brain

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Easy HPLC-based separation and quantitation of chondroitin sulphate and hyaluronan disaccharides after chondroitinase ABC treatment

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Aggrecan-based extracellular matrix shows unique cortical features and conserved subcortical principles of mammalian brain organization in the Madagascan lesser hedgehog tenrec (Echinops telfairi Martin, 1838)

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Drug Delivery Systems in the Development of Novel Strategies for Glioblastoma Treatment

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Layer-specific expression of extracellular matrix molecules in the mouse somatosensory and piriform cortices

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ECS Dynamism and Its Influence on Neuronal Excitability and Seizures

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Tissue-Engineered Models of the Human Brain: State-of-the-Art Analysis and Challenges

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The diversified hydrogels for biomedical applications and their imperative roles in tissue regeneration

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The axon as a physical structure in health and acute trauma

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Distribution and development of molecularly distinct perineuronal nets in visual thalamus

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Effects of IKAP/hELP1 Deficiency on Gene Expression in Differentiating Neuroblastoma Cells: Implications for Familial Dysautonomia

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Softening of the chronic hemi-section spinal cord injury scar parallels dysregulation of cellular and extracellular matrix content

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Exploring the properties and potential of the neural extracellular matrix for next‐generation regenerative therapies

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The Networking Brain: How Extracellular Matrix, Cellular Networks, and Vasculature Shape the In Vivo Mechanical Properties of the Brain

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Microvasculature of the Mouse Cerebral Cortex Exhibits Increased Accumulation and Synthesis of Hyaluronan With Aging

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Modifications of perineuronal nets and remodelling of excitatory and inhibitory afferents during vestibular compensation in the adult mouse

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Hierarchically structured nerve guidance channels based on poly-3-hydroxybutyrate enhance oriented axonal outgrowth

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Microcirculation of the brain: morphological assessment in degenerative diseases and restoration processes

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Molecular Determinants of Malignant Brain Cancers: From Intracellular Alterations to Invasion Mediated by Extracellular Vesicles

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Engineering biomaterial microenvironments to promote myelination in the central nervous system

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Comparison of sensory neuron growth cone and filopodial responses to structurally diverse aggrecan variants, in vitro

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Glypican-1, Phosphacan/Receptor Protein-Tyrosine Phosphatase-ζ/β and its Ligand, Tenascin-C, are Expressed by Neural Stem Cells and Neural Cells Derived from Embryonic Stem Cells

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Viscoelastic N‑cadherin-like interactions maintain neural progenitor cell stemness within 3D matrices

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Polysaccharide-based chondroitin sulfate macromolecule loaded hydrogel/scaffolds in wound healing- A comprehensive review on possibilities, research gaps, and safety assessment

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GATA Regulation and Function During the Ovarian Life Cycle

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Engineering Brain Organoids: Toward Mature Neural Circuitry with an Intact Cytoarchitecture

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Astrocytes and human artificial blood-brain barrier models

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Effect of unilateral labyrinthectomy on the molecular composition of perineuronal nets in the lateral vestibular nucleus of the rat

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From de novo peptides to native proteins: advancements in biomaterial scaffolds for acute ischemic stroke repair

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Synaptogenesis Is Modulated by Heparan Sulfate in Caenorhabditis elegans

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Lumbar and ventricular CSF concentrations of extracellular matrix proteins before and after shunt surgery in idiopathic normal pressure hydrocephalus

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Distribution of extracellular matrix molecules in human uterine tubes during the menstrual cycle: a histological and immunohistochemical analysis

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Versican V1 in human endometrial epithelial cells promotes BeWo spheroid adhesion in vitro

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3D hydrogels reveal medulloblastoma subgroup differences and identify extracellular matrix subtypes that predict patient outcome

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Serum-Free Cultures: Could They Be a Future Direction to Improve Neuronal Differentiation of Mesenchymal Stromal Cells?

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A Library of Elastin-like Proteins with Tunable Matrix Ligands for In Vitro 3D Neural Cell Culture

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Versican V0 and V1 Direct the Growth of Peripheral Axons in the Developing Chick Hindlimb

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Cerebrospinal fluid markers of extracellular matrix remodelling, synaptic plasticity and neuroinflammation before and after cranial radiotherapy

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Hyaluronan and the Aggregating Proteoglycans

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Mapping of the Wnt/β-Catenin/TCF Response Elements in the Human Versican Promoter

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Neural Plasticity and Memory

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Nanomedicine for targeting brain Neurodegeneration: Critical barriers and circadian rhythm Considerations

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Biomimetic biphasic scaffolds in osteochondral tissue engineering: Their composition, structure and consequences

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Molecular composition of extracellular matrix in the vestibular nuclei of the rat

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The Multimerization State of the Amyloid-β42 Peptide (Aβ42) Governs its Interaction Network with the Extracellular Matrix

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Wallerian degeneration: From mechanism to disease to imaging

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Dynamic Hydrogel‐Based Strategy for Traumatic Brain Injury Modeling and Therapy

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Organotypic whole hemisphere brain slice models to study the effects of donor age and oxygen-glucose-deprivation on the extracellular properties of cortical and striatal tissue

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Mecanismos de disfunção da barreira hematoencefálica no paciente criticamente enfermo: ênfase no papel das metaloproteinases de matriz

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A deficiency of the link protein Bral2 affects the size of the extracellular space in the thalamus of aged mice

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Fibrous Materials Made of Poly(ε-caprolactone)/Poly(ethylene oxide)-b-Poly(ε-caprolactone) Blends Support Neural Stem Cells Differentiation

Fernández, D., Guerra, M., Lisoni, J. G., Hoffmann, T., Araya‐Hermosilla, R., Shibue, T., Nishide, H., Moreno‐Villoslada, I., & Flores, M. E. (2019) · Polymers · doi:10.3390/polym11101621 · Cited by 17

Destroy the old to build the new: Activity-dependent lysosomal exocytosis in neurons

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Anatomo‐Functional Correlation between Head Zones and Acupuncture Channels and Points: A Comparative Analysis from the Perspective of Neural Therapy

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Region- and Cell-Specific Expression of Transmembrane Collagens in Mouse Brain

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A pericellular hyaluronan matrix is required for the morphological maturation of cortical neurons.

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CAQK, a peptide associating with extracellular matrix components targets sites of demyelinating injuries

Abi‐Ghanem, C., Jonnalagadda, D., Chun, J. J. M., Kihara, Y., & Ranscht, B. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.908401 · Cited by 16

Engineered In Vitro Tumor Model Recapitulates Molecular Signatures of Invasion in Glioblastoma

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Exploring tissue permeability of brain tumours in different grades: Insights from pore-scale fluid dynamics analysis

Yang, Y., Tian, Y., Panaitescu, C., Li, R., Wu, K., Zhou, Y., Pokrajac, D., Dini, D., & Zhan, W. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.11.005 · Cited by 17

Analysis of the potential role of photocurable hydrogel in patient-derived glioblastoma organoid culture through RNA sequencing

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Subcutaneous Maturation of Neural Stem Cell-Loaded Hydrogels Forms Region-Specific Neuroepithelium

Farrag, M., & Leipzig, N. D. (2018) · Cells · doi:10.3390/cells7100173 · Cited by 15

Alteration of Extracellular Matrix Molecules and Perineuronal Nets in the Hippocampus of Pentylenetetrazol-Kindled Mice

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Abolished perineuronal nets and altered parvalbumin-immunoreactivity in the nucleus reticularis thalami of wildtype and 3xTg mice after experimental stroke

Härtig, W., Appel, S., Suttkus, A., Grosche, J., & Michalski, D. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.09.004 · Cited by 15

Reorganization of the Brain Extracellular Matrix in Hippocampal Sclerosis

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Altered Extracellular Matrix as an Alternative Risk Factor for Epileptogenicity in Brain Tumors

de Jong, J. M., Broekaart, D. W. M., Bongaarts, A., Mühlebner, A., Mills, J. D., van Vliet, E. A., & Aronica, E. (2022) · Biomedicines · doi:10.3390/biomedicines10102475 · Cited by 15

3D biological scaffold delivers Bergenin to reduce neuroinflammation in rats with cerebral hemorrhage

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Distribution and classification of the extracellular matrix in the olfactory bulb

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Modulatory Effects of Monoamines and Perineuronal Nets on Output of Cerebellar Purkinje Cells

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Formulation Controls the Potential Neuromuscular Toxicity of Polyethylene Photoproducts in Developing Zebrafish

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Diverse functions of perlecan in central nervous system cells in vitro

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Expression Patterns of Extracellular Matrix Proteins during Posterior Commissure Development

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Cerebrospinal fluid brevican and neurocan fragment patterns in human traumatic brain injury

Minta, K., Brinkmalm, G., Thelin, E. P., Nimer, F. A., Piehl, F., Tullberg, M., Jeppsson, A., Portelius, E., Zetterberg, H., Blennow, K., et al. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.11.017 · Cited by 14

Chondroitin Sulfate is the Primary Receptor for a Peptide-Modified AAV That Targets Brain Vascular Endothelium In Vivo

Geoghegan, J. C., Keiser, N. W., Okulist, A., Martins, I., Wilson, M. S., & Davidson, B. L. (2014) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2014.50 · Cited by 14

Effects of 3D-printed exosome-functionalized brain acellular matrix hydrogel on neuroinflammation in rats following cerebral hemorrhage

Zhang, A., Sun, B., Nan, C., Cong, L., Zhao, Z., & Liu, L. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04332-3 · Cited by 15

Exploring the interstitial system in the brain: the last mile of drug delivery

Sun, Y. X., & Sun, X. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0057 · Cited by 14

Clearing-induced tisssue shrinkage: A novel observation of a thickness size effect

Vulders, R. C. M., van Hoogenhuizen, R. C., der Giessen, E. V., & van der Zaag, P. J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0261417 · Cited by 13

Biomaterials-based strategies for in vitro neural models

Özgün, A., Lomboni, D. J., Arnott, H. G., Staines, W. A., Woulfe, J., & Variola, F. (2022) · Biomaterials Science · doi:10.1039/d1bm01361k · Cited by 13

Novel electrospun conduit based on polyurethane/collagen enhanced by nanobioglass for peripheral nerve tissue engineering

Nasab, S. T., Roodbari, N. H., Goodarzi, V., Khonakdar, H. A., Mansoori, K., & Nourani, M. R. (2022) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2021.2021350 · Cited by 13

Collagen VI deficiency causes behavioral abnormalities and cortical dopaminergic dysfunction

Gregorio, I. D., Mereu, M., Contarini, G., Bello, L., Semplicini, C., Burgio, F., Russo, L., Sut, S., Dall’Acqua, S., Braghetta, P., et al. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049481 · Cited by 13

Biomaterials and 3D Printing Techniques for Neural Tissue Regeneration

Lee, S., Zhu, W., Castro, N. J., & Zhang, L. G. (2016) · Springer eBooks · doi:10.1007/978-3-319-31433-4_1 · Cited by 13

Formation of perineuronal nets within a thalamocortical circuit shapes mechanical and thermal pain thresholds in mice with neuropathic pain

Mascio, G., Notartomaso, S., Ginerete, R. P., Imbriglio, T., Bucci, D., Liberatore, F., Ceccherelli, A., Castaldi, S., Zampini, G., Cannella, M., et al. (2025) · Pain · doi:10.1097/j.pain.0000000000003563 · Cited by 12

Serum matrix metalloproteinase-9 levels and severity of symptoms in boys with attention deficit hyperactivity disorder ADHD/hyperkinetic disorder HKD

Kądziela-Olech, H., Cichocki, P., Chwiesko, J., Konstantynowicz, J., & Braszko, J. J. (2014) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-014-0533-z · Cited by 12

Nanobioglass enhanced polyurethane/collagen conduit in sciatic nerve regeneration

Nasab, S. T., Roodbari, N. H., Goodarzi, V., Khonakdar, H. A., & Nourani, M. R. (2021) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34983 · Cited by 12

Impact of hyaluronan size on localization and solubility of the extracellular matrix in the mouse brain

Egorova, D., Nomura, Y., & Miyata, S. (2023) · Glycobiology · doi:10.1093/glycob/cwad022 · Cited by 9

Extracellular matrix molecules exhibit unique expression pattern in the climbing fiber-generating precerebellar nucleus, the inferior olive

Kecskés, S., Gaál, B., Rácz, É., Birinyi, A., Hunyadi, A., & Matesz, C. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.080 · Cited by 12

The synthesis and secretion of versican isoform V3 by mammalian cells: A role for N-linked glycosylation

Harten, I. A., Kaber, G., Agarwal, K. J., Kang, I., Ibarrientos, S. R., Workman, G. A., Chan, C. K., Nivison, M. P., Nagy, N., Braun, K. R., et al. (2020) · Matrix Biology · doi:10.1016/j.matbio.2020.01.002 · Cited by 13

Physiology of Astroglia: Channels, Receptors, Transporters, Ion Signaling and Gliotransmission

Verkhratsky, A., & Parpura, V. (2015) · Colloquium Series on Neuroglia in Biology and Medicine From Physiology to Disease · doi:10.4199/c00123ed1v01y201501ngl004 · Cited by 12

Altered Synaptic Marker Abundance in the Hippocampal Stratum Oriens of Ts65Dn Mice is Associated with Exuberant Expression of Versican

Howell, M. D., & Gottschall, P. E. (2012) · ASN NEURO · doi:10.1042/an20110037 · Cited by 11

Distribution of extracellular matrix macromolecules in the vestibular nuclei and cerebellum of the frog, Rana esculenta

Gaál, B., Rácz, É., Juhász, T., Holló, K., & Matesz, C. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.10.080 · Cited by 13

Carboxymethylcellulose hydrogels support central nervous system-derived tumor-cell chemotactic migration: Comparison with conventional extracellular matrix macromolecules

Singh, T., Kothapalli, C. R., Varma, D. M., Nicoll, S. B., & Vázquez, M. (2014) · Journal of Biomaterials Applications · doi:10.1177/0885328214532969 · Cited by 11

The Mosaic of Extracellular Matrix in the Central Nervous System as a Determinant of Glial Heterogeneity

Willis, C. M., & Crocker, S. J. (2016) · InTech eBooks · doi:10.5772/62706 · Cited by 13

Bioengineered fibrin-based niche to direct outgrowth of circulating progenitors into neuron-like cells for potential use in cellular therapy

Sudhadevi, T., & Krishnan, L. K. (2015) · Journal of Neural Engineering · doi:10.1088/1741-2560/12/3/036011 · Cited by 11

Pentylenetetrazol kindling induces cortical astrocytosis and increased expression of extracellular matrix molecules in mice

Ueno, H., Suemitsu, S., Murakami, S., Kitamura, N., Wani, K., Takahashi, Y., Matsumoto, Y., Okamoto, M., & Ishihara, T. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.07.019 · Cited by 11

Bral1: “Superglue” for the extracellular matrix in the brain white matter

Cicanic, M., Syková, E., & Vargová, L. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.01.009 · Cited by 12

Neuronal growth cones and regeneration: gridlock within the extracellular matrix

Snow, D. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.128234 · Cited by 3

A ‘GAG’ reflex prevents repair of the damaged CNS

Sherman, L. S., & Back, S. A. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2007.11.001 · Cited by 116

Structural Variation of Chondroitin Sulfate and Its Roles in the Central Nervous System

Maeda, N. (2010) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/187152410790780136 · Cited by 43

Proteoglycans of the Central Nervous System

Gupta, G. (2012) · Springer eBooks · doi:10.1007/978-3-7091-1065-2_38 · Cited by 1

Chondroitin sulfate: A key molecule in the brain matrix

Kwok, J. C. F., Warren, P. M., & Fawcett, J. W. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.01.004 · Cited by 138