Cited by 465Proteoglycans and glycosaminoglycans researchNerve injury and regenerationNeurogenesis and neuroplasticity mechanisms

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Extracellular matrix of the central nervous system: from neglect to challenge

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Zimmermann, Dieter R., Dours-Zimmermann, María T.·2008·Histochemistry and Cell Biology

DOI 10.1007/s00418-008-0485-9

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Abstract

The basic concept, that specialized extracellular matrices rich in hyaluronan, chondroitin sulfate proteoglycans (aggrecan, versican, neurocan, brevican, phosphacan), link proteins and tenascins (Tn-R, Tn-C) can regulate cellular migration and axonal growth and thus, actively participate in the development and maturation of the nervous system, has in recent years gained rapidly expanding experimental support. The swift assembly and remodeling of these matrices have been associated with axonal guidance functions in the periphery and with the structural stabilization of myelinated fiber tracts and synaptic contacts in the maturating central nervous system. Particular interest has been focused on the putative role of chondroitin sulfate proteoglycans in suppressing central nervous system regeneration after lesions. The axon growth inhibitory properties of several of these chondroitin sulfate proteoglycans in vitro, and the partial recovery of structural plasticity in lesioned animals treated with chondroitin sulfate degrading enzymes in vivo have significantly contributed to the increased awareness of this long time neglected structure.

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Authors: Zimmermann, D. R., & Dours-Zimmermann, M. T.
Affiliations: University Hospital Zurich (CH)
Corresponding author: Zimmermann, Dieter R.
Venue: Histochemistry and Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2008-08-12
Volume: 130
Issue: 4
Pages: 635-653
ISSN: 0948-6143 (ISSN-L)
1432-119X
DOI: 10.1007/s00418-008-0485-9
OpenAlex: W2146369085
Cited by: 465
References: 240
Citations by year: 2026: 16 · 2025: 20 · 2024: 29 · 2023: 27 · 2022: 31 · 2021: 30 · 2020: 30 · 2019: 31 · 2018: 35 · 2017: 18 · 2016: 28 · 2015: 27 · 2014: 42 · 2013: 22 · 2012: 18
FWCI: 1.63
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/2.0 (tdm)
creativecommons.org/licenses/by-nc/2.0 (vor)
Locations: Histochemistry and Cell Biology (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
reroDoc Digital Library (submittedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich)
Funders: National Science Foundation
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Universität Zürich
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: extracellular matrix, central nervous system, hyaluronic acid, chondroitin sulfate proteoglycans, aggrecan, versican, neurocan, brevican, phosphacan, tenascin, axon guidance, axon growth, myelination, synapse maturation, central nervous system regeneration, lesion recovery, structural plasticity
MeSH terms: Animals, Axons, Central Nervous System, Extracellular Matrix, Humans, Chondroitin Sulfate Proteoglycans

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Extracellular matrix of the central nervous system: from neglect to challenge

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