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Extracellular matrix of the central nervous system: from neglect to challenge
Open accessAbstract
The basic concept, that specialized extracellular matrices rich in hyaluronan, chondroitin sulfate proteoglycans (aggrecan, versican, neurocan, brevican, phosphacan), link proteins and tenascins (Tn-R, Tn-C) can regulate cellular migration and axonal growth and thus, actively participate in the development and maturation of the nervous system, has in recent years gained rapidly expanding experimental support. The swift assembly and remodeling of these matrices have been associated with axonal guidance functions in the periphery and with the structural stabilization of myelinated fiber tracts and synaptic contacts in the maturating central nervous system. Particular interest has been focused on the putative role of chondroitin sulfate proteoglycans in suppressing central nervous system regeneration after lesions. The axon growth inhibitory properties of several of these chondroitin sulfate proteoglycans in vitro, and the partial recovery of structural plasticity in lesioned animals treated with chondroitin sulfate degrading enzymes in vivo have significantly contributed to the increased awareness of this long time neglected structure.
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“During development, the ECM, and CSPGs in particular, regulate neuronal migration, axon outgrowth, synaptogenesis and synaptic maturation.23, 27, 28, 29, 30, 31”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [29]
Experimental — accuracy not yet measuredIn the citing paper
“The main components are hyaluronan (Figure 1), chondroitin sulfate proteoglycans (CSPGs) (i.e. aggrecan, brevican, neurocan, versican and phosphocan) (Figure 2), tenascins (Figure 3), and link proteins”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Zimmermann and Dours-Zimmermann, 2008
In the citing paper
“the perinodal-matrix or peridonal net, a PNN-like structure (Dours-Zimmermann et al., 2009; Zimmermann and Dours-Zimmermann, 2008), is commonly associated with the node of Ranvier”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Zimmermann and Dours-Zimmermann, 2008
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Metadata
- Authors
- Zimmermann, D. R., & Dours-Zimmermann, M. T.
- Affiliations
- University Hospital Zurich (CH)
- Corresponding author
- Zimmermann, Dieter R.
- Venue
- Histochemistry and Cell Biology
- Published
- 2008-08-12
- Volume
- 130
- Issue
- 4
- Pages
- 635-653
- ISSN
- 0948-6143 (ISSN-L)
- 1432-119X
- OpenAlex
- W2146369085
- Cited by
- 465
- References
- 240
- Citations by year
- 2026: 16 · 2025: 20 · 2024: 29 · 2023: 27 · 2022: 31 · 2021: 30 · 2020: 30 · 2019: 31 · 2018: 35 · 2017: 18 · 2016: 28 · 2015: 27 · 2014: 42 · 2013: 22 · 2012: 18
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Histochemistry and Cell Biology (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- reroDoc Digital Library (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Universität Zürich
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- extracellular matrix, central nervous system, hyaluronic acid, chondroitin sulfate proteoglycans, aggrecan, versican, neurocan, brevican, phosphacan, tenascin, axon guidance, axon growth, myelination, synapse maturation, central nervous system regeneration, lesion recovery, structural plasticity
- MeSH terms
- Animals, Axons, Central Nervous System, Extracellular Matrix, Humans, Chondroitin Sulfate Proteoglycans
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