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Cited by 114Advanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity StudiesCognitive Abilities and Testing

Quantification of the spatiotemporal microstructural organization of the human brain association, projection and commissural pathways across the lifespan using diffusion tensor tractography

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Hasan, Khader M., Kamali, Arash, Abid, Humaira, Kramer, Larry A., Fletcher, Jack M., Ewing-Cobbs, Linda·2010·Brain Structure and Function
DOI 10.1007/s00429-009-0238-0PMC PMC2864323
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Abstract

Using diffusion tensor tractography, we quantified the microstructural changes in the association, projection, and commissural compact white matter pathways of the human brain over the lifespan in a cohort of healthy right-handed children and adults aged 6-68 years. In both males and females, the diffusion tensor radial diffusivity of the bilateral arcuate fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, uncinate fasciculus, corticospinal, somatosensory tracts, and the corpus callosum followed a U-curve with advancing age; fractional anisotropy in the same pathways followed an inverted U-curve. Our study provides useful baseline data for the interpretation of data collected from patients.

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Cited by

Sorted by citations

Authors
Hasan, K. M., Kamali, A., Abid, H., Kramer, L. A., Fletcher, J. M., & Ewing-Cobbs, L.
Affiliations
  • The University of Texas Health Science Center at Houston (US)
  • University of Houston (US)
Corresponding author
Hasan, Khader M.
ORCID
Venue
Brain Structure and Function
Publisher
Springer Science and Business Media LLC
Published
2010-02-04
Volume
214
Issue
4
Pages
361-373
ISSN
  • 1863-2653 (ISSN-L)
  • 1863-2661
DOI
10.1007/s00429-009-0238-0
PMC
PMC2864323
OpenAlex
W1999972116
Cited by
114
References
9
Citations by year
2025: 7 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 11 · 2019: 9 · 2018: 9 · 2017: 8 · 2016: 7 · 2015: 8 · 2014: 2 · 2013: 13 · 2012: 6
FWCI
8.47
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Brain Structure and Function (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Commons-TMC (Texas Medical Center) (submittedVersion)
Funders
  • University of Texas Health Science Center at Houston
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (R01NS046308, R01NS052505)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD035946)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
white matter microstructure, association tracts, commissural tracts, arcuate fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, uncinate fasciculus, corticospinal tract, corpus callosum, radial diffusivity, fractional anisotropy, U-shaped curve, inverted U-shaped relationship, children and adults
MeSH terms
Adolescent, Adult, Age Factors, Aged, Aging, Brain, Child, Corpus Callosum, Female, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Fibers, Myelinated, Neural Pathways, Sex Factors, Cohort Studies, Diffusion Magnetic Resonance Imaging, Young Adult

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