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Cited by 346Advanced Neuroimaging Techniques and ApplicationsCognitive Abilities and TestingFunctional Brain Connectivity Studies

Quantitative fiber tracking of lateral and interhemispheric white matter systems in normal aging: relations to timed performance

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Sullivan, Edith V., Rohlfing, Torsten, Pfefferbaum, Adolf·2010·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2008.04.007PMC PMC2815144
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Abstract

The integrity of white matter, as measured in vivo with diffusion tensor imaging (DTI), is disrupted in normal aging. A current consensus is that in adults advancing age affects anterior brain regions disproportionately more than posterior regions; however, the mainstay of studies supporting this anterior-posterior gradient is based primarily on measures of the corpus callosum. Using our quantitative fiber tracking approach, we assessed fiber tract integrity of samples of major white matter cortical, subcortical, interhemispheric, and cerebellar systems (11 bilateral and 2 callosal) on DTI data collected at 1.5T magnet strength. Participants were 55 men (age 20-78 years) and 65 women (age 28-81 years), deemed healthy and cognitively intact following interview and behavioral testing. Fiber integrity was measured as orientational diffusion coherence (fractional anisotropy, FA) and magnitude of diffusion, which was quantified separately for longitudinal diffusivity (lambdaL), an index of axonal length or number, and transverse diffusivity (lambdaT), an index of myelin integrity. Aging effects were more evident in diffusivity than FA measures. Men and women, examined separately, showed similar age-related increases in longitudinal and transverse diffusivity in fibers of the internal and external capsules bilaterally and the fornix. FA was lower and diffusivity higher in anterior than posterior fibers of regional paired comparisons (genu versus splenium and frontal versus occipital forceps). Diffusivity with older age was generally greater or FA lower in the superior than inferior fiber systems (longitudinal fasciculi, cingulate bundles), with little to no evidence for age-related degradation in pontine or cerebellar systems. The most striking sex difference emerged for the corpus callosum, for which men showed significant decline in FA and increase in longitudinal and transverse diffusivity in the genu but not splenium. By contrast, in women the age effect was present in both callosal regions, albeit modestly more so in the genu than splenium. Functional meaningfulness of these age-related differences was supported by significant correlations between DTI signs of white matter degradation and poorer performance on cognitive or motor tests. This survey of multiple fiber systems throughout the brain revealed a differential pattern of age's effect on regional FA and diffusivity and suggests mechanisms of functional degradation, attributed at least in part to compromised fiber microstructure affecting myelin and axonal morphology.

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Crossref · 10.1016/j.neurobiolaging.2008.04.007

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  • Across brain systems, prefrontal association tracts are the most vulnerable to aging, while cingulum, temporal and parietal-occipital commissural connections are relatively preserved.

    “revealing a typical spatial degeneration pattern across brain systems in which prefrontal association tracts are the most vulnerable to aging, while cingulum, temporal and parietal-occipital commissural connections are relatively preserved.”

    From Quantitative mapping of the brain’s structural connectivity using diffusion MRI tractography: A review (2022) · cites this paper as Sullivan et al., 2010

    The Results (section 3.3) identify the frontal forceps as having the most prominent age-related FA decrease, and the Discussion (section 4) describes greater susceptibility in anterior than posterior bundles. But the proposed preservation is too broad: section 4 reports age-related changes in the superior cingulum, while section 3.4 reports significant age effects in temporal and parietal callosal sectors. Page numbers are unavailable in our copy. (LLM, conf=0.87)

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Authors
Sullivan, E. V., Rohlfing, T., & Pfefferbaum, A.
Affiliations
  • Stanford Medicine (US)
  • SRI International (US)
Corresponding author
Sullivan, Edith V.
ORCID
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2010-03
Volume
31
Issue
3
Pages
464-481
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/j.neurobiolaging.2008.04.007
PMC
PMC2815144
OpenAlex
W2058486187
Cited by
346
References
118
Citations by year
2026: 6 · 2025: 12 · 2024: 10 · 2023: 15 · 2022: 17 · 2021: 18 · 2020: 17 · 2019: 21 · 2018: 21 · 2017: 11 · 2016: 17 · 2015: 13 · 2014: 20 · 2013: 23 · 2012: 26
FWCI
25.42
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Alcohol Abuse and Alcoholism (R01AA012388, AA012388, R37AA010723, AA010723, R01AA010723)
  • National Institute on Aging (AG017919, R01AG017919)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
normal aging, white matter integrity, diffusion tensor imaging, fractional anisotropy, corpus callosum, anterior-posterior gradient, sex differences, internal capsule, external capsule, fornix, myelin integrity, axon morphology
MeSH terms
Adult, Aged, Aged, 80 and over, Aging, Brain, Cognition, Corpus Callosum, Female, Humans, Male, Middle Aged, Motor Activity, Nerve Fibers, Myelinated, Neural Pathways, Neuropsychological Tests, Psychomotor Performance, Sex Characteristics, Time Factors, Anisotropy, Young Adult, Diffusion Tensor Imaging

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