Frontal terminations for the inferior fronto-occipital fascicle: anatomical dissection, DTI study and functional considerations on a multi-component bundle.
Abstract
The anatomy and functional role of the inferior fronto-occipital fascicle (IFOF) remain poorly known. We accurately analyze its course and the anatomical distribution of its frontal terminations. We propose a classification of the IFOF in different subcomponents. Ten hemispheres (5 left, 5 right) were dissected with Klingler's technique. In addition to the IFOF dissection, we performed a 4-T diffusion tensor imaging study on a single healthy subject. We identified two layers of IFOF. The first one is superficial and antero-superiorly directed, terminating in the inferior frontal gyrus. The second is deeper and consists of three portions: posterior, middle and anterior. The posterior component terminates in the middle frontal gyrus (MFG) and dorso-lateral prefrontal cortex. The middle component terminates in the MFG and lateral orbito-frontal cortex. The anterior one is directed to the orbito-frontal cortex and frontal pole. In vivo tractography study confirmed these anatomical findings. We suggest that the distribution of IFOF fibers within the frontal lobe corresponds to a fine functional segmentation. IFOF can be considered as a "multi-function" bundle, with each anatomical subcomponent subserving different brain processing. The superficial layer and the posterior component of the deep layer, which connects the occipital extrastriate, temporo-basal and inferior frontal cortices, might subserve semantic processing. The middle component of the deep layer could play a role in…
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The study confirmed frontal IFOF terminations within the inferior frontal and lateral and medial fronto-orbital gyri, and also in the superior and middle frontal gyri.
“Our study first confirmed frontal IFOF terminations within the inferior frontal and lateral and medial fronto-orbital gyri corresponding to the conventional IFOF definition, but also in the superior and middle frontal gyri”
From Cortical Terminations of the Inferior Fronto-Occipital and Uncinate Fasciculi: Anatomical Stem-Based Virtual Dissection (2016) · cites this paper as Sarubbo et al., 2013
Post-mortem dissection studies have noted considerable overlap between the infero-superior course of the IFOF and antero-posterior course of the arcuate fasciculus near the inferior and middle frontal regions.
“Post-mortem dissection studies have noted considerable overlap between the infero-superior course of the IFOF and antero-posterior course of the arcuate fasciculus near the inferior and middle frontal regions (Martino et al., 2010; Sarubbo et al., 2013).”
From Cortical Terminations of the Inferior Fronto-Occipital and Uncinate Fasciculi: Anatomical Stem-Based Virtual Dissection (2016) · cites this paper as Sarubbo et al., 2013
These lateral/medial lateralization patterns are consistent with the different superficial/deep subcomponents of the IFOF defined by Sarubbo et al. (2013).
“Interestingly, these lateral/medial lateralization patterns are consistent with the different superficial/deep subcomponents of the IFOF defined by Sarubbo et al. (2013).”
From Cortical Terminations of the Inferior Fronto-Occipital and Uncinate Fasciculi: Anatomical Stem-Based Virtual Dissection (2016) · cites this paper as Sarubbo et al. (2013)
Projections to the parietal lobe are systematically excluded using the method of Zhang et al. (2010) and are likely to be missed using the method of Catani and Thiebaut de Schotten (2008), as was the case in Sarubbo et al. (2013).
“As shown Figure 8, projections to the parietal lobe are systematically excluded using the method of Zhang et al. (2010) and are likely to be missed using the method of Catani and Thiebaut de Schotten (2008) that use ROIs delineated around the frontal and occipital lobes, as was the case in Sarubbo et al. (2013).”
From Cortical Terminations of the Inferior Fronto-Occipital and Uncinate Fasciculi: Anatomical Stem-Based Virtual Dissection (2016) · cites this paper as Sarubbo et al. (2013)
The study consistently observed a cleavage zone within the ventral portion of the external capsule between the UF fibers turning anteriorly and inferiorly to the temporal lobe and the IFOF fibers going deeply and dorsally.
“As such, we consistently observed a cleavage zone within the ventral portion of the external capsule between the UF fibers turning anteriorly and inferiorly to the temporal lobe (including the superior, middle and inferior temporal gyri posterior to the temporal pole) and the IFOF fibers going deeply and dorsally (Martino et al., 2010; Sarubbo et al., 2013).”
From Cortical Terminations of the Inferior Fronto-Occipital and Uncinate Fasciculi: Anatomical Stem-Based Virtual Dissection (2016) · cites this paper as Sarubbo et al., 2013
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“But, IFOF projections to the superior and middle frontal (Sarubbo et al., 2013; Caverzasi et al., 2014), medial occipital (i.e., the lingual gyrus and cuneus) (Lawes et al., 2008; Martino et al., 2011; Caverzasi et al., 2014; Forkel et al., 2014), temporobasal (Crosby et al., 1962; Catani and…”
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- Authors
- Sarubbo, S., De Benedictis, A., Maldonado, I. L., Basso, G., & Duffau, H.
- Affiliations
- University of Ferrara (IT)
- Centre Hospitalier Universitaire de Montpellier (FR)
- University of Trento (IT)
- Inserm (FR)
- Corresponding author
- Duffau, Hugues
- Venue
- Brain Structure and Function
- Published
- 2011-12-27
- Volume
- 218
- Issue
- 1
- Pages
- 21-37
- ISSN
- 1863-2653 (ISSN-L)
- 1863-2661
- OpenAlex
- W2089904026
- Cited by
- 345
- References
- 3
- Citations by year
- 2026: 11 · 2025: 25 · 2024: 16 · 2023: 20 · 2022: 24 · 2021: 46 · 2020: 23 · 2019: 26 · 2018: 25 · 2017: 27 · 2016: 30 · 2015: 26 · 2014: 23 · 2013: 19 · 2012: 4
- FWCI
- 11.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Brain Structure and Function (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Iris (University of Trento) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Anatomy › Medical and Biological Sciences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- middle frontal gyrus, orbitofrontal cortex, frontal pole, diffusion tensor imaging, tractography, semantic processing, sensorimotor integration
- MeSH terms
- Behavior, Cerebral Cortex, Dissection, Emotions, Frontal Lobe, Humans, Models, Neurological, Neural Pathways, Occipital Lobe, Temporal Lobe, Diffusion Tensor Imaging
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