Revisiting the human uncinate fasciculus, its subcomponents and asymmetries with stem-based tractography and microdissection validation
Open accessAbstract
Despite its significant functional and clinical interest, the anatomy of the uncinate fasciculus (UF) has received little attention. It is known as a 'hook-shaped' fascicle connecting the frontal and anterior temporal lobes and is believed to consist of multiple subcomponents. However, the knowledge of its precise connectional anatomy in humans is lacking, and its subcomponent divisions are unclear. In the present study, we evaluate the anatomy of the UF and provide its detailed normative description in 30 healthy subjects with advanced particle-filtering tractography with anatomical priors and robustness to crossing fibers with constrained spherical deconvolution. We extracted the UF by defining its stem encompassing all streamlines that converge into a compact bundle, which consisted not only of the classic hook-shaped fibers, but also of straight horizontally oriented. We applied an automatic-clustering method to subdivide the UF bundle and revealed five subcomponents in each hemisphere with distinct connectivity profiles, including different asymmetries. A layer-by-layer microdissection of the ventral part of the external and extreme capsules using Klingler's preparation also demonstrated five types of uncinate fibers that, according to their pattern, depth, and cortical terminations, were consistent with the diffusion-based UF subcomponents. The present results shed new light on the UF cortical terminations and its multicomponent internal organization with extended cortical connections within the frontal and temporal cortices. The different lateralization patterns we report within the UF subcomponents reconcile the conflicting asymmetry findings of the literature. Such results clarifying the UF structural anatomy lay the groundwork for more targeted investigations of its functional role, especially in semantic language processing.
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Post-mortem dissection with Klingler's method reveals the macroscopic organization of the human brain white matter, although this method shares some limitations of tractography in complex fiber configurations or near the cortex.
“Currently, post-mortem dissection with Klingler’s method reveals the macroscopic organization of the human brain white matter11, 62–64, although this method shares some of the mentioned limitations of tractography in complex fiber configurations or near the cortex.”
From Tractography-based connectomes are dominated by false-positive connections (2016) · cites this paper as [64]
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Tractography-based connectomes are dominated by false-positive connections
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- Authors
- Hau, J., Sarubbo, S., Houde, J. C., Corsini, F., Girard, G., Deledalle, C., Crivello, F., Zago, L., Mellet, E., Jobard, G., Joliot, M., Mazoyer, B., Tzourio-Mazoyer, N., Descoteaux, M., & Petit, L.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Ospedale Santa Chiara (IT)
- Université de Sherbrooke (CA)
- Corresponding author
- Petit, Laurent
- ORCID
- Venue
- Brain Structure and Function
- Published
- 2016-08-31
- Volume
- 222
- Issue
- 4
- Pages
- 1645-1662
- ISSN
- 1863-2653 (ISSN-L)
- 1863-2661
- OpenAlex
- W2515350692
- Cited by
- 121
- References
- 78
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 8 · 2023: 9 · 2022: 16 · 2021: 22 · 2020: 15 · 2019: 10 · 2018: 14 · 2017: 7
- FWCI
- 8.97
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- Locations
- Brain Structure and Function (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Institutional Research Information System (Università degli Studi di Trento) (submittedVersion)
- Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion)
- Funders
- LabEx TRAIL Bordeaux (ANR-10-LABX-57)
- Agence Nationale de la Recherche (BIOMIST - no. ANR-13-CORD-0007)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Anatomy › Medical and Biological Sciences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- uncinate fasciculus, hemispheric lateralization, frontal lobe connectivity, anterior temporal lobe, external capsule, extreme capsule, diffusion MRI tractography
- MeSH terms
- Adult, Female, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Male, Neural Pathways, Temporal Lobe, Diffusion Magnetic Resonance Imaging, Microdissection, Young Adult, Diffusion Tensor Imaging, White Matter
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Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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