The huge plastic potential of adult brain and the role of connectomics: new insights provided by serial mappings in glioma surgery
Abstract
While prominent in the traditional literature, the localizationist and static view of brain processing does not explain numerous observations of functional recovery following cerebral damages. Here, the goal is to revisit this classical modular and inflexible model by proposing a dynamic organization of brain circuits, which allows postlesional cerebral adaptative phenomena able to maintain neurological and cognitive functions, even in adults. In this state of mind, recent data provided by serial mappings performed in patients who underwent awake surgery for diffuse glioma infiltrating eloquent structures will be reviewed. Firstly, the use of intraoperative electrical mapping enables the realization of on-line anatomo-functional correlations both at cortical and subcortical levels, supporting a network distribution of the brain, and resulting in the reappraisal of cognitive models - notably regarding language. Secondly, combination of neuropsychological assessments and functional neuroimaging before and after operation demonstrates that it is possible to achieve massive resections of "critical" regions without eliciting permanent sequelae, thanks to reorganization of cerebral circuits. Thirdly, repeated surgeries in cases of tumor relapse show functional remapping in the same patients over time. Taken together, these findings open the window toward a huge plastic potential of human central nervous system (CNS) in adults. However, a better understanding of cerebral connectomics leads to the conclusion that the white matter connectivity constitutes a main limitation of such brain plasticity, explaining the lack of recovery in patients with extensive subcortical damages.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The association between persistent speech production impairments and white matter damage aligns with prior evidence suggesting that white matter damage poses a major constraint on brain plasticity.
“The association between persistent speech production impairments and white matter damage aligns well with prior evidence suggesting that white matter damage poses a major constraint on brain plasticity (Duffau, 2014; Herbet et al., 2016; Griffis et al., 2019).”
From Damage to Broca’s area does not contribute to long-term speech production outcome after stroke (2021) · cites this paper as Duffau, 2014
Cites
The cortical organization of speech processing
Hickok, G., & Poeppel, D. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2113 · Cited by 5,495 · see citing works
The brainweb: phase synchronization and large-scale integration
Varela, F., Lachaux, J.-P., Rodriguez, E., & Martinerie, J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35067550 · Cited by 4,761 · see citing works
The Human Connectome: A Structural Description of the Human Brain
Sporns, O., Tononi, G., & Kötter, R. (2005) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0010042 · Cited by 3,260 · see citing works
Meta-analyzing left hemisphere language areas: phonology, semantics, and sentence processing.
Vigneau, M., Beaucousin, V., Hervé, P. Y., Duffau, H., Crivello, F., Houdé, O., Mazoyer, B., & Tzourio-Mazoyer, N. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.11.002 · Cited by 1,851 · see citing works
Self-citationPerisylvian language networks of the human brain
Catani, M., Jones, D. K., & ffytche, D. H. (2005) · Annals of Neurology · doi:10.1002/ana.20319 · Cited by 1,832 · see citing works
Network structure of cerebral cortex shapes functional connectivity on multiple time scales
Honey, C. J., Kötter, R., Breakspear, M. J., & Sporns, O. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701519104 · Cited by 1,683 · see citing works
Cortical language localization in left, dominant hemisphere
Ojemann, G. A., Ojemann, J. G., Lettich, E., & Berger, M. S. (1989) · Journal of neurosurgery · doi:10.3171/jns.1989.71.3.0316 · Cited by 1,491 · see citing works
The Organization of Language and the Brain
Geschwind, N. (1970) · Science · doi:10.1126/science.170.3961.940 · Cited by 1,141 · see citing works
Impact of Intraoperative Stimulation Brain Mapping on Glioma Surgery Outcome: A Meta-Analysis
Hamer, P. C. D. W., Robles, S. G., Zwinderman, A. H., Duffau, H., & Berger, M. S. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.38.4818 · Cited by 1,046 · see citing works
Self-citationHuman brain networks in health and disease
Bassett, D. S., & Bullmore, E. T. (2009) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32832d93dd · Cited by 894 · see citing works
Extensive Cortical Rewiring after Brain Injury
Dancause, N., Barbay, S., Frost, S. B., Plautz, E. J., Chen, D., Zoubina, E. V., Stowe, A. M., & Nudo, R. J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3256-05.2005 · Cited by 704 · see citing works
Direct Evidence for a Parietal-Frontal Pathway Subserving Spatial Awareness in Humans
de Schotten, M. T., Urbanski, M., Duffau, H., Volle, E., Lévy, R., Dubois, B., & Bartolomeo, P. (2005) · Science · doi:10.1126/science.1116251 · Cited by 682 · see citing works
Self-citationDuffau, H. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70140-x · Cited by 680 · see citing works
Self-citationMonkey to human comparative anatomy of the frontal lobe association tracts
Thiebaut de Schotten, M., Dell’Acqua, F., Valabregue, R., & Catani, M. (2012) · Cortex · doi:10.1016/j.cortex.2011.10.001 · Cited by 632 · see citing works
Duffau, H., Gatignol, P., Mandonnet, E., Peruzzi, P., Tzourio-mazoyer, N., & Capelle, L. (2005) · Brain : a journal of neurology · doi:10.1093/brain/awh423 · Cited by 601 · see citing works
Self-citationDuffau, H., Lopes, M., Arthuis, F., Bitar, A., Sichez, J., van Effenterre, R., & Capelle, L. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.048520 · Cited by 596 · see citing works
Self-citationIntraoperative mapping of the subcortical language pathways using direct stimulations
Duffau, H., Capelle, L., Sichez, N., Denvil, D., Lopes, M., Sichez, J. P., Bitar, A., & Fohanno, D. (2002) · Brain · doi:10.1093/brain/awf016 · Cited by 573 · see citing works
Self-citationModeling the impact of lesions in the human brain
Alstott, J., Breakspear, M., Hagmann, P., Cammoun, L., & Sporns, O. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000408 · Cited by 561 · see citing works
Duffau, H., Capelle, L., Denvil, D., Sichez, N., Gatignol, P., Taillandier, L., Lopes, M., Mitchell, M.-C., Roche, S., Muller, J.-C., et al. (2003) · Journal of Neurosurgery · doi:10.3171/jns.2003.98.4.0764 · Cited by 523 · see citing works
Self-citationContrasting acute and slow-growing lesions: a new door to brain plasticity
Desmurget, M., Bonnetblanc, F., & Duffau, H. (2006) · Brain · doi:10.1093/brain/awl300 · Cited by 515 · see citing works
Self-citationDuffau, H., Gatignol, P., Mandonnet, E., Capelle, L., & Taillandier, L. (2008) · Journal of neurosurgery · doi:10.3171/jns/2008/109/9/0461 · Cited by 499 · see citing works
Self-citationMartino, J., Brogna, C., Robles, S. G., Vergani, F., & Duffau, H. (2010) · Cortex · doi:10.1016/j.cortex.2009.07.015 · Cited by 476 · see citing works
Self-citationPreferential brain locations of low‐grade gliomas
Duffau, H., & Capelle, L. (2004) · Cancer · doi:10.1002/cncr.20297 · Cited by 448 · see citing works
Self-citationRaphaël Gaillard, B., Naccache, L., Pinel, P., Clémenceau, S., Emmanuelle Volle, C., Hasboun, D., Dupont, S., Baulac, M., Dehaene, S., Adam, C., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.031 · Cited by 440 · see citing works
Capelle, L., Fontaine, D., Mandonnet, E., Taillandier, L., Golmard, J. L., Bauchet, L., Pallud, J., Peruzzi, P., Baron, M. H., Kujas, M., et al. (2013) · Journal of neurosurgery · doi:10.3171/2013.1.jns121 · Cited by 419 · see citing works
Self-citationBello, L., Gambini, A., Castellano, A., Carrabba, G. G., Acerbi, F., Fava, E., Giussani, C. G., Cadioli, M., Blasi, V., Casarotti, A., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.08.031 · Cited by 416 · see citing works
Does the left inferior longitudinal fasciculus play a role in language? A brain stimulation study
Mandonnet, E., Nouet, A., Gatignol, P., Capelle, L., & Duffau, H. (2007) · Brain · doi:10.1093/brain/awl361 · Cited by 398 · see citing works
Self-citationDuffau, H., Moritz-Gasser, S., & Mandonnet, E. (2014) · Brain and Language · doi:10.1016/j.bandl.2013.05.011 · Cited by 367 · see citing works
Self-citationIus, T., Angelini, E., de Schotten, M. T., Mandonnet, E., & Duffau, H. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.03.022 · Cited by 364 · see citing works
Self-citationBrain plasticity: From pathophysiological mechanisms to therapeutic applications
Duffau, H. (2006) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2005.11.045 · Cited by 355 · see citing works
Self-citationCognitive Rehabilitation in Patients With Gliomas: A Randomized, Controlled Trial
Gehring, K., Sitskoorn, M. M., Gundy, C. M., Sikkes, S. A. M., Klein, M., Postma, T. J., van den Bent, M. J., Beute, G. N., Enting, R. H., Kappelle, A. C., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.20.5765 · Cited by 346 · see citing works
Sarubbo, S., De Benedictis, A., Maldonado, I. L., Basso, G., & Duffau, H. (2013) · Brain Structure and Function · doi:10.1007/s00429-011-0372-3 · Cited by 345 · see citing works
Self-citationThe anatomo-functional connectivity of language revisited
Duffau, H. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.10.025 · Cited by 343 · see citing works
Self-citationDuffau, H. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.7.901 · Cited by 336 · see citing works
Self-citationBello, L., Gallucci, M., Fava, M., Carrabba, G., Giussani, C., Acerbi, F., Baratta, P., Songa, V., Conte, V., Branca, V., et al. (2007) · Neurosurgery · doi:10.1227/01.neu.0000249206.58601.de · Cited by 312 · see citing works
Martino, J., De Witt Hamer, P. C., Berger, M. S., Lawton, M. T., Arnold, C. M., de Lucas, E. M., & Duffau, H. (2013) · Brain Structure and Function · doi:10.1007/s00429-012-0386-5 · Cited by 280 · see citing works
Duffau, H. (2006) · Journal of Neuro-Oncology · doi:10.1007/s11060-005-9109-6 · Cited by 249 · see citing works
Self-citationIs the left uncinate fasciculus essential for language?
Duffau, H., Gatignol, P., Moritz‐Gasser, S., & Mandonnet, E. (2009) · Journal of Neurology · doi:10.1007/s00415-009-0053-9 · Cited by 237 · see citing works
Self-citationElectrophysiological Transcortical Diaschisis After Cortical Photothrombosis in Rat Brain
Buchkremer-Ratzmann, I., August, M., Hagemann, G., & Witte, O. W. (1996) · Stroke · doi:10.1161/01.str.27.6.1105 · Cited by 233 · see citing works
Robles, S. G., Gatignol, P., Lehéricy, S., & Duffau, H. (2008) · Journal of neurosurgery · doi:10.3171/jns/2008/109/10/0615 · Cited by 232 · see citing works
Self-citationDuffau, H. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00203-9 · Cited by 220 · see citing works
Self-citationInterhemispheric Asymmetries of Motor Cortex Excitability in the Postacute Stroke Stage
Cicinelli, P., Pasqualetti, P., Zaccagnini, M., et al. (2003) · Stroke · doi:10.1161/01.str.0000092122.96722.72 · Cited by 220 · see citing works
Mandonnet, E., Winkler, P., & Duffau, H. (2009) · Acta Neurochirurgica · doi:10.1007/s00701-009-0469-0 · Cited by 217 · see citing works
Self-citationThe role of dominant striatum in language: a study using intraoperative electrical stimulations
Robles, S. G. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.045948 · Cited by 215 · see citing works
Duffau, H. (2009) · Journal of neurosurgery · doi:10.3171/2008.8.jns08741 · Cited by 213 · see citing works
Self-citationRole of the supplementary motor area in motor deficit following medial frontal lobe surgery
Krainik, A., Lehéricy, S., Duffau, H., et al. (2001) · Neurology · doi:10.1212/wnl.57.5.871 · Cited by 212 · see citing works
Self-citationRole of the healthy hemisphere in recovery after resection of the supplementary motor area
Krainik, A., Duffau, H., Capelle, L., Cornu, P., Boch, A., Mangin, J.-F., Bihan, D. L., Marsault, C., Jacques Chiras, C., & Lehéricy, S. (2004) · Neurology · doi:10.1212/01.wnl.0000120547.83482.b1 · Cited by 205 · see citing works
Self-citationAssessment of verbal working memory before and after surgery for low-grade glioma
Teixidor, P., Gatignol, P., Leroy, M., Aumatell, C. M., Capelle, L., & Duffau, H. (2006) · Journal of Neuro-Oncology · doi:10.1007/s11060-006-9233-y · Cited by 204 · see citing works
Self-citationMoritz-Gasser, S., Herbet, G., & Duffau, H. (2013) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2013.06.007 · Cited by 201 · see citing works
Self-citationFontaine, D., Capelle, L., & Duffau, H. (2002) · Neurosurgery · doi:10.1097/00006123-200202000-00011 · Cited by 193 · see citing works
Self-citationBrain Hodotopy: From Esoteric Concept to Practical Surgical Applications
BENEDICTIS, A. D., & Duffau, H. (2011) · Neurosurgery · doi:10.1227/neu.0b013e3182124690 · Cited by 186 · see citing works
Self-citationHow do brain tumors alter functional connectivity? A magnetoencephalography study
Bartolomei, F., Bosma, I., Klein, M., Baayen, J. C., Reijneveld, J. C., Postma, T. J., Heimans, J. J., van Dijk, B. W., de Munck, J. C., de Jongh, A., et al. (2006) · Annals of Neurology · doi:10.1002/ana.20710 · Cited by 180 · see citing works
Duffau, H. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.70.4.506 · Cited by 175 · see citing works
Self-citationRESECTION OF WORLD HEALTH ORGANIZATION GRADE II GLIOMAS INVOLVING BROCA'S AREA
Benzagmout, M., Gatignol, P., & Duffau, H. (2007) · Neurosurgery · doi:10.1227/01.neu.0000298902.69473.77 · Cited by 174 · see citing works
Self-citationMandonnet, E., Capelle, L., & Duffau, H. (2006) · Journal of Neuro-Oncology · doi:10.1007/s11060-005-9084-y · Cited by 174 · see citing works
Self-citationDuffau, H., Denvil, D., & Capelle, L. (2002) · PubMed · doi:10.1136/jnnp.72.4.511 · Cited by 173 · see citing works
Self-citationStam, C. J. (2010) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2010.06.024 · Cited by 169 · see citing works
The challenge to remove diffuse low-grade gliomas while preserving brain functions
Duffau, H. (2012) · Acta Neurochirurgica · doi:10.1007/s00701-012-1275-7 · Cited by 164 · see citing works
Self-citationMaldonado, I. L., Moritz-Gasser, S., & Duffau, H. (2011) · Brain Structure and Function · doi:10.1007/s00429-011-0309-x · Cited by 161 · see citing works
Self-citationRobles, S. G., & Duffau, H. (2010) · Neurosurgical FOCUS · doi:10.3171/2009.12.focus09236 · Cited by 154 · see citing works
Self-citationThe articulatory loop: study of the subcortical connectivity by electrostimulation
Duffau, H., Gatignol, P., Denvil, D., Lopes, M., & Capelle, L. (2003) · Neuroreport · doi:10.1097/00001756-200310270-00026 · Cited by 152 · see citing works
Self-citationCognition and resective surgery for diffuse infiltrative glioma: an overview
Klein, M., Duffau, H., & Hamer, P. C. D. W. (2012) · Journal of Neuro-Oncology · doi:10.1007/s11060-012-0811-x · Cited by 149 · see citing works
Self-citationBosma, I., Douw, L., Bartolomei, F., Heimans, J. J., van Dijk, B. W., Postma, T. J., Stam, C. J., Reijneveld, J. C., & Klein, M. (2008) · Neuro-Oncology · doi:10.1215/15228517-2008-034 · Cited by 145 · see citing works
Catani, M. (2007) · Brain · doi:10.1093/brain/awm008 · Cited by 143 · see citing works
Speaking without Broca's area after tumor resection
Plaza, M., Gatignol, P., Leroy, M., & Duffau, H. (2009) · Neurocase · doi:10.1080/13554790902729473 · Cited by 142 · see citing works
Self-citationFunctional compensation of the left dominant insula for language
Duffau, H., Bauchet, L., Lehéricy, S., & Capelle, L. (2001) · Neuroreport · doi:10.1097/00001756-200107200-00023 · Cited by 139 · see citing works
Self-citationMartino, J., Taillandier, L., Moritz‐Gasser, S., Gatignol, P., & Duffau, H. (2009) · Acta Neurochirurgica · doi:10.1007/s00701-009-0232-6 · Cited by 138 · see citing works
Self-citationDuffau, H. (2008) · Advances and technical standards in neurosurgery · doi:10.1007/978-3-211-72283-1_1 · Cited by 133 · see citing works
Self-citationGras-Combe, G., Moritz-Gasser, S., Herbet, G., & Duffau, H. (2012) · Journal of Neurosurgery · doi:10.3171/2012.6.jns111981 · Cited by 128 · see citing works
Self-citationHow do brain tumors alter functional connectivity? A magnetoencephalography study
Timone, C. (2006) · Cited by 128 · see citing works
The insular lobe and brain plasticity: Lessons from tumor surgery
Duffau, H., Taillandier, L., Gatignol, P., & Capelle, L. (2005) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2005.09.004 · Cited by 123 · see citing works
Self-citationHamer, P. C. D. W., Moritz‐Gasser, S., Gatignol, P., & Duffau, H. (2010) · Human Brain Mapping · doi:10.1002/hbm.21082 · Cited by 122 · see citing works
Self-citationWhite matter functional connectivity as an additional landmark for dominant temporal lobectomy
Duffau, H., de Schotten, M. T., & Mandonnet, E. (2008) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2007.121004 · Cited by 121 · see citing works
Self-citationMaldonado, I., Moritz-Gasser, S., de Champfleur, N. D., Bertram, L., Moulinié, G., & Duffau, H. (2011) · Journal of Neurosurgery · doi:10.3171/2011.5.jns112 · Cited by 118 · see citing works
Self-citationvan Geemen, K., Herbet, G., Moritz‐Gasser, S., & Duffau, H. (2014) · Human Brain Mapping · doi:10.1002/hbm.22275 · Cited by 115 · see citing works
Self-citationDoes post-lesional subcortical plasticity exist in the human brain?
Duffau, H. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.07.002 · Cited by 113 · see citing works
Self-citationSubcortical electrostimulation to identify network subserving motor control
Schucht, P., Moritz-Gasser, S., Herbet, G., Raabe, A., & Duffau, H. (2013) · Human Brain Mapping · doi:10.1002/hbm.22122 · Cited by 104 · see citing works
Self-citationBlonski, M., Taillandier, L., Herbet, G., et al. (2011) · Journal of Neuro-Oncology · doi:10.1007/s11060-011-0670-x · Cited by 102 · see citing works
Moritz-Gasser, S., Herbet, G., Maldonado, I. L., & Duffau, H. (2012) · Journal of Neuro-Oncology · doi:10.1007/s11060-011-0789-9 · Cited by 99 · see citing works
Self-citationThe “frontal syndrome” revisited: Lessons from electrostimulation mapping studies
Duffau, H. (2011) · Cortex · doi:10.1016/j.cortex.2011.04.029 · Cited by 98 · see citing works
Self-citationEvidence for an occipito-temporal tract underlying visual recognition in picture naming.
Mandonnet, E., Gatignol, P., & Duffau, H. (2009) · Clinical neurology and neurosurgery (Dutch-Flemish ed. Print) · doi:10.1016/j.clineuro.2009.03.007 · Cited by 95 · see citing works
Self-citationSarubbo, S., Bars, E. L., Moritz‐Gasser, S., & Duffau, H. (2011) · Neurosurgical Review · doi:10.1007/s10143-011-0351-4 · Cited by 83 · see citing works
Self-citationHolland, R., & Ralph, M. A. L. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq020 · Cited by 77 · see citing works
Double Dissociation Between Visual Recognition and Picture Naming
Robles, S. G., Carvallo, A., de la Peña, M. J., Caicoya, A. G., Martinez, R., Ruiz-Ocaña, C., & Duffau, H. (2012) · Neurosurgery · doi:10.1227/neu.0b013e318282a361 · Cited by 76 · see citing works
Self-citationPlaza, M., Gatignol, P., Cohen, H., Berger, B., & Duffau, H. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm169 · Cited by 74 · see citing works
Self-citationLubrano, V., Draper, L., & Roux, F. (2010) · Neurosurgery · doi:10.1227/01.neu.0000368442.92290.04 · Cited by 73 · see citing works
Garbizu, J. M., García‐Armengol, R., Moritz‐Gasser, S., & Duffau, H. (2010) · Human Brain Mapping · doi:10.1002/hbm.21026 · Cited by 65 · see citing works
Self-citationKeidel, J. L., Welbourne, S. R., & Ralph, M. A. L. (2010) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.02.019 · Cited by 65 · see citing works
Connectivity constraints on cortical reorganization of neural circuits involved in object naming
Papagno, C., Gallucci, M., Casarotti, A., Castellano, A., Falini, A., Fava, E., Giussani, C. G., Carrabba, G. G., Bello, L., & Caramazza, A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.01.005 · Cited by 65 · see citing works
Double dissociation between picture naming and comprehension: an electrostimulation study
Gatignol, P., Capelle, L., Bihan, R. L., & Duffau, H. (2003) · Neuroreport · doi:10.1097/00001756-200401190-00037 · Cited by 60 · see citing works
Self-citationSchucht, P., Ghareeb, F., & Duffau, H. (2013) · Journal of neurosurgery · doi:10.3171/2013.5.jns122235 · Cited by 56 · see citing works
Self-citationBrain dynamics across levels of organization
Werner, G. (2007) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2007.12.001 · Cited by 51 · see citing works
(2012) · doi:10.1007/978-3-7091-0723-2 · Cited by 50 · see citing works
Meningeal cells can communicate with astrocytes by calcium signaling
Grafstein, B., Liu, S., Cotrina, M. L., Goldman, S. A., & Nedergaard, M. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200001)47:1 · Cited by 50 · see citing works
Cognitive processes and neural basis of language switching: proposal of a new model
Moritz‐Gasser, S., & Duffau, H. (2009) · Neuroreport · doi:10.1097/wnr.0b013e328333907e · Cited by 49 · see citing works
Self-citationBrain Mapping: From Neural Basis of Cognition to Surgical Applications
Kubben, P. (2012) · Europe PMC (PubMed Central) · Cited by 47 · see citing works
Absence of movement disorders after resection of glioma invading the right striatum
Duffau, H., Denvil, D., & Capelle, L. (2002) · Journal of neurosurgery · doi:10.3171/jns.2002.97.2.0363 · Cited by 46 · see citing works
Self-citationSzalisznyó, K., Silverstein, D. N., Duffau, H., & Smits, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069798 · Cited by 44 · see citing works
Self-citationFunctional compensation of the claustrum: lessons from low-grade glioma surgery
Duffau, H., Mandonnet, E., Gatignol, P., et al. (2006) · Journal of Neuro-Oncology · doi:10.1007/s11060-006-9236-8 · Cited by 43 · see citing works
Self-citationDuffau, H. (2013) · DIAL (Catholic University of Leuven) · doi:10.1007/978-1-4471-2213-5 · Cited by 42 · see citing works
Self-citationDuffau, H., Karachi, C., Gatignol, P., et al. (2003) · Neurosurgery · doi:10.1227/01.neu.0000073990.94180.54 · Cited by 36 · see citing works
Self-citationDuffau, H., & Capelle, L. (2001) · PubMed · Cited by 27 · see citing works
Self-citationMeunier, S., Duffau, H., Garnero, L., et al. (2000) · NeuroImage · doi:10.1016/s1053-8119(00)91796-8 · Cited by 9 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Mapping neuroplastic potential in brain-damaged patients
Herbet, G., Maheu, M., Costi, E., Lafargue, G., & Duffau, H. (2016) · Brain · doi:10.1093/brain/awv394 · Cited by 289 · see citing works
Self-citationDamage to Broca’s area does not contribute to long-term speech production outcome after stroke
Gajardo-Vidal, A., Lorca-Puls, D. L., team, P., Warner, H., Pshdary, B., Crinion, J. T., Leff, A. P., Hope, T. M. H., Geva, S., Seghier, M. L., et al. (2021) · Brain · doi:10.1093/brain/awaa460 · Cited by 150 · see citing works
Resection of gliomas deemed inoperable by neurosurgeons based on preoperative imaging studies
Southwell, D. G., Birk, H. S., Han, S. J., Li, J., Sall, J. W., & Berger, M. S. (2018) · Journal of Neurosurgery · doi:10.3171/2017.5.jns17166 · Cited by 71 · see citing works
Duffau, H. (2021) · Acta Neurochirurgica · doi:10.1007/s00701-021-04752-z · Cited by 69 · see citing works
Self-citation
- Authors
- Duffau, H.
- Affiliations
- Inserm (FR)
- Corresponding author
- Duffau, Hugues
- ORCID
- Duffau, Hugues
- Venue
- Cortex
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 58
- Pages
- 325-337
- ISSN
- 0010-9452 (ISSN-L)
- OpenAlex
- W2065442514
- Cited by
- 331
- References
- 103
- Citations by year
- 2026: 24 · 2025: 22 · 2024: 10 · 2023: 24 · 2022: 32 · 2021: 28 · 2020: 31 · 2019: 20 · 2018: 29 · 2017: 40 · 2016: 23 · 2015: 22 · 2014: 24 · 2013: 2
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cortex (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Keywords
- neuroplasticity, glioma surgery, connectomics, functional reorganization, language lateralization, white matter connectivity, eloquent brain areas, tumor recurrence, subcortical lesions
- MeSH terms
- Brain, Brain Mapping, Brain Neoplasms, Glioma, Humans, Nerve Net, Neural Pathways, Neurosurgical Procedures, Connectome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
