Prefrontal-hippocampal coupling by theta rhythm and by 2-5 Hz oscillation in the delta band: the role of the nucleus reuniens of the thalamus
Open accessAbstract
Rhythmic synchronizations of hippocampus (HC) and prefrontal cortex (PFC) at theta frequencies (4-8 Hz) are thought to mediate key cognitive functions, and disruptions of HC-PFC coupling were implicated in psychiatric diseases. Theta coupling is thought to represent a HC-to-PFC drive transmitted via the well-described unidirectional HC projection to PFC. In comparison, communication in the PFC-to-HC direction is less understood, partly because no known direct anatomical connection exists. Two recent findings, i.e., reciprocal projections between the thalamic nucleus reuniens (nRE) with both PFC and HC and a unique 2-5 Hz rhythm reported in the PFC, indicate, however, that a second low-frequency oscillation may provide a synchronizing signal from PFC to HC via nRE. Thus, in this study, we recorded local field potentials in the PFC, HC, and nRE to investigate the role of nRE in PFC-HC coupling established by the two low-frequency oscillations. Using urethane-anesthetized rats and stimulation of pontine reticular formation to experimentally control the parameters of both forebrain rhythms, we found that theta and 2-5 Hz rhythm were dominant in HC and PFC, respectively, but were present and correlated in all three signals. Removal of nRE influence, either statistically (by partialization of PFC-HC correlation when controlling for the nRE signal) or pharmacologically (by lidocaine microinjection in nRE), resulted in decreased coherence between the PFC and HC 2-5-Hz oscillations, but had minimal effect on theta coupling. This study proposes a novel thalamo-cortical network by which PFC-to-HC coupling occurs via a 2-5 Hz oscillation and is mediated through the nRe.
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Microinjection of lidocaine into the NR decreased the coherence of 2-5 Hz but not theta between the PFC and hippocampus in rats.
“Microinjection of lidocaine into the NR decreased the coherence of 2–5 Hz, but not theta, between the PFC and hippocampus in rats”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Roy et al., 2017
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- Authors
- Roy, A., Svensson, F. P., Mazeh, A., & Kocsis, B.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Venue
- Brain Structure and Function
- Published
- 2017-02-16
- Volume
- 222
- Issue
- 6
- Pages
- 2819-2830
- ISSN
- 1863-2653 (ISSN-L)
- 1863-2661
- PMC
- PMC5542875
- OpenAlex
- W2587808164
- Cited by
- 99
- References
- 43
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 7 · 2023: 11 · 2022: 10 · 2021: 12 · 2020: 18 · 2019: 11 · 2018: 12 · 2017: 8
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Brain Structure and Function (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH100820)
- National Heart, Lung, and Blood Institute (HL095491)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- theta oscillations, nucleus reuniens, thalamus, hippocampus, prefrontal cortex, thalamocortical network, local field potentials, neuronal synchronization
- MeSH terms
- Anesthetics, Local, Animals, Cortical Synchronization, Delta Rhythm, Electric Stimulation, Hippocampus, Lidocaine, Male, Microinjections, Neural Pathways, Periodicity, Theta Rhythm, Time Factors, Rats, Sprague-Dawley, Prefrontal Cortex, Midline Thalamic Nuclei
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