Two types of hippocampal rhythmical slow activity in both the rabbit and the rat: Relations to behavior and effects of atropine, diethyl ether, urethane, and pentobarbital
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Classical work in rodents demonstrated two mechanistically distinct types of theta oscillations: fast Type-1 (atropine-insensitive) theta oscillations (7-11 Hz) during locomotion, and slower Type-2 (atropine-sensitive) oscillations (4-7 Hz) thought to occur preferentially during immobility.
“Classical work in rodents has demonstrated the existence of two mechanistically distinct types of theta oscillations: fast Type-1 (atropine-insensitive) theta oscillations (7–11 Hz), which are observed during locomotion, and slower Type-2 (atropine-sensitive) oscillations (4–7 Hz), which are thought to preferentially occur during immobility26–28,42,50,97.”
From Place and behavioral modulation of hippocampal neurons during immobility (2026) · cites this paper as [97]
In vivo theta rhythm has been reported to be either atropine resistant or atropine sensitive.
“the in vivo theta rhythm has been reported to be either atropine resistant or atropine sensitive”
From Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit (2016) · cites this paper as Kramis et al., 1975
Atropine resistant theta is typically associated with walking and may not be dependent on neuromodulatory inputs.
“the former is typically associated with walking and may not be dependent on neuromodulatory inputs”
From Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit (2016) · cites this paper as Kramis et al., 1975
Atropine sensitive theta requires intact, rhythmic cholinergic inputs.
“the latter requires intact, rhythmic cholinergic inputs”
From Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit (2016) · cites this paper as Kramis et al., 1975
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- Authors
- Kramis, R., Vanderwolf, C. H., & Bland, B. H.
- Affiliations
- Western University (CA)
- Corresponding author
- Vanderwolf, C.H.
- Venue
- Experimental Neurology
- Publisher
- Elsevier BV
- Published
- 1975-10
- Volume
- 49
- Issue
- 1
- Pages
- 58-85
- ISSN
- 0014-4886 (ISSN-L)
- OpenAlex
- W2049289902
- Cited by
- 791
- References
- 25
- Citations by year
- 2026: 16 · 2025: 26 · 2024: 15 · 2023: 23 · 2022: 25 · 2021: 28 · 2020: 23 · 2019: 19 · 2018: 20 · 2017: 31 · 2016: 15 · 2015: 22 · 2014: 24 · 2013: 29 · 2012: 24
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- hippocampal theta rhythm, atropine sensitivity, urethane anesthesia, pentobarbital, hypothalamic stimulation, midbrain reticular formation, drug effects on behavior
- MeSH terms
- Animals, Atropine, Dose-Response Relationship, Drug, Drinking Behavior, Electroencephalography, Ether, Ethyl Ethers, Feeding Behavior, Grooming, Hippocampus, Hypothalamus, Mesencephalon, Motor Activity, Neural Pathways, Pentobarbital, Posture, Rabbits, Reticular Formation, Theta Rhythm, Urethane, Rats
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