Prefrontal phase locking to hippocampal theta oscillations

Siapas, Athanassios G.; Lubenov, Evgueniy V.; Wilson, Matthew A.

doi:10.1016/j.neuron.2005.02.028

Cited by 1,014Neural dynamics and brain functionMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Prefrontal phase locking to hippocampal theta oscillations

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Siapas, Athanassios G., Lubenov, Evgueniy V., Wilson, Matthew A.·2005·Neuron

DOI 10.1016/j.neuron.2005.02.028

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Abstract

The interactions between cortical and hippocampal circuits are critical for memory formation, yet their basic organization at the neuronal network level is not well understood. Here, we demonstrate that a significant portion of neurons in the medial prefrontal cortex of freely behaving rats are phase locked to the hippocampal theta rhythm. In addition, we show that prefrontal neurons phase lock best to theta oscillations delayed by approximately 50 ms and confirm this hippocampo-prefrontal directionality and timing at the level of correlations between single cells. Finally, we find that phase locking of prefrontal cells is predicted by the presence of significant correlations with hippocampal cells at positive delays up to 150 ms. The theta-entrained activity across cortico-hippocampal circuits described here may be important for gating information flow and guiding the plastic changes that are believed to underlie the storage of information across these networks.

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Theta waves are maintained, probably by an external input, while local gamma oscillations reduce their presence by a putative imbalance of excitatory-inhibitory activity as a consequence of the loss of perisomatic synapses on PV cells.
“Based on these results, we hypothesize that u waves are maintained, probably by an external input (Siapas et al., 2005;Sirota et al., 2008), while the local g oscillations reduce their presence by a putative imbalance of the excitatory-inhibitory activity as a consequence of the loss of perisomatic synapses on PV cells.”
From Perineuronal Nets Regulate the Inhibitory Perisomatic Input onto Parvalbumin Interneurons and γ Activity in the Prefrontal Cortex (2020) · cites this paper as Siapas et al., 2005
PFC-hippocampal projections generate oscillatory synchronization and support the concept of a directional pathway from hippocampus towards PFC as focal for information processing.
“This illustrates that the PFC-hippocampal projections generate an oscillatory synchronization and supports the concept of a directional pathway of hippocampus towards the PFC as focal for information processing”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Siapas et al., 2005
A portion of PFC neurons were coupled to the theta rhythm (4-10 Hz) of the hippocampus and best matched with a delay of approximately 50 ms.
“a portion of the PFC neurons were found to be coupled to the theta rhythm (4–10 Hz) of the hippocampus and to best match with a delay of approximately 50 ms”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Siapas et al., 2005

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Authors: Siapas, A. G., Lubenov, E. V., & Wilson, M. A.
Affiliations: California Institute of Technology (US)
Massachusetts Institute of Technology (US)
Corresponding author: Siapas, Athanassios G.
ORCID: Siapas, Athanassios G.
Lubenov, Evgueniy V.
Wilson, Matthew A.
Venue: Neuron
Publisher: Elsevier BV
Published: 2005-04
Volume: 46
Issue: 1
Pages: 141-151
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2005.02.028
OpenAlex: W2129217278
Cited by: 1,014
References: 58
Citations by year: 2026: 33 · 2025: 47 · 2024: 53 · 2023: 47 · 2022: 47 · 2021: 63 · 2020: 54 · 2019: 40 · 2018: 50 · 2017: 55 · 2016: 45 · 2015: 56 · 2014: 47 · 2013: 63 · 2012: 48
FWCI: 17.04
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3029 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: phase locking, hippocampal theta rhythm, medial prefrontal cortex, neuronal synchronization, memory formation, single-unit activity
MeSH terms: Animals, Hippocampus, Male, Neural Pathways, Neurons, Theta Rhythm, Prefrontal Cortex, Rats

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Prefrontal phase locking to hippocampal theta oscillations

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