Efficacy of Emodepside plus Praziquantel Tablets (Profender® Tablets for Dogs) against Mature and Immature Adult Trichuris vulpis Infections in Dogs
Abstract
This paper reports on the efficacy of a novel flavoured tablet formulation of emodepside plus praziquantel (Profender tablets for dogs) against mature and immature adult whipworms (Trichuris vulpis) at the proposed minimum dose of 1 mg emodepside and 5 mg praziquantel per kg body weight in dogs. Three randomised, blinded and controlled laboratory studies with naturally or experimentally infected dogs were performed. The first study was conducted as a dose determination study in experimentally infected dogs using three different dose levels, i.e., 0.5x, 1x and 2x the minimum therapeutic dose. Two further studies confirmed the efficacy of emodepside plus praziquantel tablets against mature and immature adult T. vulpis at the recommended minimum dose. In all three studies, the efficacy against mature and immature adult T. vulpis was >99%. No side effects of the treatment were observed. It is concluded that the emodepside plus praziquantel tablet is an effective and safe treatment against mature and immature adult stages of T. vulpis in dogs.
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Experimental and field studies have demonstrated nearly 100% efficacy of a new anthelmintic tablet formulation containing emodepside against immature and mature T. vulpis and other major canine intestinal nematodes and cestodes.
“Experimental and field studies have demonstrated the nearly 100% efficacy of a new anthelmintic tablet formulation containing the cyclooctadepsipeptide emodepside against immature and mature T. vulpis and other major canine intestinal nematodes and cestodes [69,70].”
From Are we paying too much attention to cardio-pulmonary nematodes and neglecting old-fashioned worms like Trichuris vulpis? (2011) · cites this paper as [70]
Cites
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BackgroundInfluentialGastrointestinal parasites of shepherd and hunting dogs in the Serres Prefecture, Northern Greece
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Self-citationMORPHOLOGICAL CHANGES IN THE INTESTINE OF DOGS, EXPERIMENTALLY INFECTED WITH TRICHURIS VULPIS
Kirkova, Z., & Dinev, I. (2005) · Bulgarian Portal for Open Science · Cited by 24 · see citing works
Schroeder, I., Altreuther, G., Schimmel, A., et al. (2009) · Parasitology Research · doi:10.1007/s00436-009-1493-y · Cited by 23 · see citing works
Self-citationSchimmel, A., Altreuther, G., Schroeder, I., et al. (2009) · Parasitology Research · doi:10.1007/s00436-009-1490-1 · Cited by 21 · see citing works
Self-citationAltreuther, G., Schimmel, A., Schroeder, I., et al. (2009) · Parasitology Research · doi:10.1007/s00436-009-1489-7 · Cited by 18 · see citing works
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- Authors
- Schimmel, A., Altreuther, G., Schroeder, I., Charles, S., Cruthers, L., Kok, D. J., Kraemer, F., & Krieger, K. J.
- Affiliations
- Bayer (Germany) (DE)
- Elanco Animal Health (Germany) (DE)
- Clinvet (ZA)
- University of Veterinary Medicine Hannover, Foundation (DE)
- Corresponding author
- Altreuther, Gertraut
- ORCID
- Altreuther, Gertraut
- Venue
- Parasitology Research
- Published
- 2009-06-28
- Volume
- 105
- Issue
- S1
- Pages
- 17-22
- ISSN
- 0044-3255 (ISSN-L)
- 0932-0113
- 1432-1955
- OpenAlex
- W2014009324
- Cited by
- 16
- References
- 15
- Citations by year
- 2021: 4 · 2020: 1 · 2019: 1 · 2018: 1 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Parasitology Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Keywords
- emodepside, praziquantel, Trichuris vulpis, trichuriasis, dogs, anthelmintic efficacy, dose determination, experimental infection, treatment safety
- MeSH terms
- Administration, Oral, Animals, Anthelmintics, Dog Diseases, Dogs, Double-Blind Method, Feces, Parasite Egg Count, Placebos, Praziquantel, Tablets, Trichuriasis, Trichuris, Treatment Outcome, Depsipeptides
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