Field Evaluation of the Efficacy and Safety of Emodepside plus Praziquantel Tablets (Profender® Tablets for Dogs) against Naturally Acquired Nematode and Cestode Infections in Dogs
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A controlled, blinded and randomised multicentre field study evaluated the efficacy and safety of a new anthelmintic tablet formulation containing emodepside plus praziquantel (Profender tablets for dogs) in the treatment of gastrointestinal nematode and cestode infections in dogs in France, Germany, Portugal and Slovakia. Dogs positive for nematodes and/or cestodes (demonstrated by faecal egg counts and/or the presence of proglottids) were treated with emodepside plus praziquantel tablets (n = 239) or the reference product containing milbemycin oxime and praziquantel (Milbemax [n = 115]) at the recommended dose rate. Two faecal samples collected between 7 and 13 days after treatment were evaluated for proglottids, nematode and cestode eggs. No suspected adverse drug reactions were observed in the study. The following parasite species were identified: Trichuris vulpis, Toxocara canis, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum, Dipylidium caninum, Taeniidae and Mesocestoides spp. Geometric mean nematode egg counts in dogs treated with emodepside plus praziquantel tablets were reduced by 99.9 % compared with a reduction of 99.6 % for the reference product. Statistical analysis demonstrated noninferiority of investigational versus reference product (p = 0.0342). None of the dogs treated with emodepside plus praziquantel or reference product remained positive for cestodes after treatment. The study demonstrated that emodepside plus praziquantel tablets are safe and highly efficacious against a broad spectrum of nematodes and cestodes under field conditions.
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Flavoured chewable tablets containing milbemycin oxime presented high acceptance by treated animals, going from 64% to 94.8% directly from the owners' hand.
“Flavoured chewable tablets containing milbemycin oxime presented also high acceptance by treated animals, going from 64% to 94.8% directly from the owners’ hand [141,169]”
From Pet roundworms and hookworms: A continuing need for global worming (2012) · cites this paper as [141]
Practices across Europe have reported high acceptance by dogs treated with oral tablets containing emodepside.
“practices across Europe have reported a high acceptance by dogs treated with the oral tablets containing emodepside [141]”
From Pet roundworms and hookworms: A continuing need for global worming (2012) · cites this paper as [141]
Experimental and field studies have demonstrated nearly 100% efficacy of a new anthelmintic tablet formulation containing emodepside against immature and mature T. vulpis and other major canine intestinal nematodes and cestodes.
“Experimental and field studies have demonstrated the nearly 100% efficacy of a new anthelmintic tablet formulation containing the cyclooctadepsipeptide emodepside against immature and mature T. vulpis and other major canine intestinal nematodes and cestodes [69,70].”
From Are we paying too much attention to cardio-pulmonary nematodes and neglecting old-fashioned worms like Trichuris vulpis? (2011) · cites this paper as [69]
Tablets containing milbemycin oxime and praziquantel were reported by practitioners to be accepted by 64% of treated dogs.
“While tablets containing milbemycin oxime and praziquantel were reported by different practitioners to be accepted by 64% of treated dogs [69]”
From Are we paying too much attention to cardio-pulmonary nematodes and neglecting old-fashioned worms like Trichuris vulpis? (2011) · cites this paper as [69]
Oral associations of milbemycin oxime with either lufenuron or praziquantel showed an efficacy of 99.6-100% in treating whipworm infection.
“Oral associations of milbemycin oxime with either lufenuron or praziquantel showed an efficacy of 99.6-100% in treating whipworm infection [69,75].”
From Are we paying too much attention to cardio-pulmonary nematodes and neglecting old-fashioned worms like Trichuris vulpis? (2011) · cites this paper as [69]
Cites
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Grandemange, E., Claerebout, E., Genchi, C., et al. (2006) · Veterinary Parasitology · doi:10.1016/j.vetpar.2006.11.013 · Cited by 42 · see citing works
Schroeder, I., Altreuther, G., Schimmel, A., et al. (2009) · Parasitology Research · doi:10.1007/s00436-009-1493-y · Cited by 23 · see citing works
Self-citationSchimmel, A., Altreuther, G., Schroeder, I., et al. (2009) · Parasitology Research · doi:10.1007/s00436-009-1490-1 · Cited by 21 · see citing works
Self-citationAltreuther, G., Schimmel, A., Schroeder, I., et al. (2009) · Parasitology Research · doi:10.1007/s00436-009-1489-7 · Cited by 18 · see citing works
Self-citationSchimmel, A., Altreuther, G., Schroeder, I., Charles, S., Cruthers, L., Kok, D. J., Kraemer, F., & Krieger, K. J. (2009) · Parasitology Research · doi:10.1007/s00436-009-1491-0 · Cited by 16 · see citing works
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Pet roundworms and hookworms: A continuing need for global worming
Traversa, D. (2012) · Parasites & Vectors · doi:10.1186/1756-3305-5-91 · Cited by 221 · see citing works
Traversa, D. (2011) · Parasites & Vectors · doi:10.1186/1756-3305-4-32 · Cited by 148 · see citing works
Helminth control in kennels: is the combination of milbemycin oxime and praziquantel a right choice?
Rinaldi, L., Pennacchio, S., Musella, V., Maurelli, M., La Torre, F., & Cringoli, G. (2015) · Parasites & Vectors · doi:10.1186/s13071-015-0647-2 · Cited by 23 · see citing works
Altreuther, G., Gasda, N., Adler, K., Hellmann, K., Thurieau, H., Schimmel, A., Hutchens, D., & Krieger, K. J. (2011) · Parasitology Research · doi:10.1007/s00436-011-2399-z · Cited by 21 · see citing works
Self-citationSchimmel, A., Altreuther, G., Schroeder, I., Charles, S., Cruthers, L., Kok, D. J., Kraemer, F., & Krieger, K. J. (2009) · Parasitology Research · doi:10.1007/s00436-009-1491-0 · Cited by 16 · see citing works
Self-citation
- Authors
- Altreuther, G., Radeloff, I., LeSueur, C., Schimmel, A., & Krieger, K. J.
- Affiliations
- Elanco Animal Health (Germany) (DE)
- Corresponding author
- Altreuther, Gertraut
- ORCID
- Altreuther, Gertraut
- Venue
- Parasitology Research
- Published
- 2009-06-28
- Volume
- 105
- Issue
- S1
- Pages
- 23-30
- ISSN
- 0044-3255 (ISSN-L)
- 0932-0113
- 1432-1955
- OpenAlex
- W2095348319
- Cited by
- 27
- References
- 7
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 1 · 2018: 1 · 2017: 2 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 4
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Parasitology Research (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, cc-by)
- Topics
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Health Sciences › Medicine › Pathology and Forensic Medicine › Parasitic infections in humans and animals
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Keywords
- emodepside, praziquantel, anthelmintic efficacy, dogs, gastrointestinal nematode infection, cestode infection, Trichuris vulpis, Toxocara canis, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum, Dipylidium caninum, Taeniidae, Mesocestoides, fecal egg count, non-inferiority, drug safety, milbemycin oxime
- MeSH terms
- Administration, Oral, Animals, Anthelmintics, Cestoda, Cestode Infections, Dog Diseases, Dogs, Double-Blind Method, Feces, France, Germany, Nematoda, Nematode Infections, Parasite Egg Count, Portugal, Praziquantel, Tablets, Treatment Outcome, Slovakia, Macrolides, Depsipeptides
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