Oxytocin in the prelimbic medial prefrontal cortex reduces anxiety-like behavior in female and male rats
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The neuropeptide oxytocin (OT) is anxiolytic in rodents and humans. However, the specific brain regions where OT acts to regulate anxiety requires further investigation. The medial prefrontal cortex (mPFC) has been shown to play a role in the modulation of anxiety-related behavior. In addition, the mPFC contains OT-sensitive neurons, expresses OT receptors, and receives long range axonal projections from OT-producing neurons in the hypothalamus, suggesting that the mPFC may be a target where OT acts to diminish anxiety. To investigate this possibility, female rats were administered OT bilaterally into the prelimbic (PL) region of the mPFC and anxiety-like behavior assessed. In addition, to determine if the effects of OT on anxiety-like behavior are sex dependent and to evaluate the specificity of OT, male and female anxiety-like behavior was tested following delivery of either OT or the closely related neuropeptide arginine vasopressin (AVP) into the PL mPFC. Finally, the importance of endogenous OT in the regulation of anxiety-like behavior was examined in male and female rats that received PL infusions of an OT receptor antagonist (OTR-A). Overall, even though males and females showed some differences in their baseline levels of anxiety-like behavior, OT in the PL region of the mPFC decreased anxiety regardless of sex. In contrast, neither AVP nor an OTR-A affected anxiety-like behavior in males or females. Together, these findings suggest that although endogenous OT in the PL region of the mPFC does not influence anxiety, the PL mPFC is a site where exogenous OT may act to attenuate anxiety-related behavior independent of sex.
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mPFC/aMCC activities are modulated by administered OT.
“and mPFC/aMCC activities are modulated by administered OT (Sabihi et al., 2014; Eckstein et al., 2015; Liu et al., 2017; Wang et al., 2017).”
From A neurobiological association of revenge propensity during intergroup conflict (2020) · cites this paper as Sabihi et al., 2014
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- Authors
- Sabihi, S., Durosko, N. E., Dong, S. M., & Leuner, B.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Leuner, Benedetta
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 45
- Pages
- 31-42
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC4067951
- OpenAlex
- W2103264859
- Cited by
- 106
- References
- 103
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 9 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 14 · 2019: 13 · 2018: 11 · 2017: 11 · 2016: 6 · 2015: 7 · 2014: 4
- FWCI
- 13.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (R0084148)
- National Institute of Mental Health (R00MH084148)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, anxiety-like behavior, vasopressin, oxytocin receptor antagonist, sex differences, anxiolytic effects
- MeSH terms
- Animals, Anxiety, Behavior, Animal, Female, Male, Oxytocin, Anti-Anxiety Agents, Down-Regulation, Rats, Sprague-Dawley, Prefrontal Cortex, Receptors, Oxytocin, Rats, Infusions, Intraventricular
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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