O xytocin modulation of neural circuits for social behavior
Abstract
Oxytocin is a hypothalamic neuropeptide that has gained attention for the effects on social behavior. Recent findings shed new light on the mechanisms of oxytocin in synaptic plasticity and adaptively modifying neural circuits for social interactions such as conspecific recognition, pair bonding, and maternal care. Here, we review several of these newer studies on oxytocin in the context of previous findings, with an emphasis on social behavior and circuit plasticity in various brain regions shown to be enriched for oxytocin receptors. We provide a framework that highlights current circuit-level mechanisms underlying the widespread action of oxytocin. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 77: 169-189, 2017.
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The coupling in paired voles between OXTR and the eCB system may reinforce the value of social interactions.
“Given OXT’s well-documented involvement in social-specific behaviors 19,46, the coupling in paired voles between OXTR and the eCB system may therefore reinforce the value of social interactions 39.”
From Social experience alters oxytocinergic modulation in the nucleus accumbens of female prairie voles (2022) · cites this paper as [46]
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“This,andsimilarexperimentsin rodentsexaminingolfactoryprocessing(Oettletal.,2016)haveledtothe hypothesis that OT tunes inhibitory circuits to increase the salience (signal/noise ratio) of important social stimuli (Marlin & Froemke, 2017; Mitre, Minder, Morina, Chao, & Froemke, 2017).”
BackgroundDiversity of central oxytocinergic projections
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Context-dependent activation of a social behavior brain network during learned vocal production
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- Authors
- Marlin, B. J., & Froemke, R. C.
- Affiliations
- Howard Hughes Medical Institute (US)
- New York University (US)
- Corresponding author
- Froemke, Robert C.
- Venue
- Developmental Neurobiology
- Publisher
- Wiley
- Published
- 2016-10-04
- Volume
- 77
- Issue
- 2
- Pages
- 169-189
- ISSN
- 1932-8451 (ISSN-L)
- 1932-846X
- OpenAlex
- W2519797740
- Cited by
- 130
- References
- 188
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 8 · 2023: 11 · 2022: 19 · 2021: 19 · 2020: 7 · 2019: 13 · 2018: 16 · 2017: 12 · 2016: 2
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- McKnight Foundation
- National Institute on Deafness and Other Communication Disorders
- Pew Charitable Trusts
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- oxytocin, social behavior, neural circuits, synaptic plasticity, oxytocin receptor, pair bonding, maternal care, conspecific recognition, hypothalamus, circuit plasticity
- MeSH terms
- Animals, Brain, Humans, Neuronal Plasticity, Oxytocin, Social Behavior
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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