Neural functions of hypothalamic oxytocin and its regulation

Wang, Ping; Wang, Stephani C.; Liu, Xiaoyu; Jia, Shuwei; Wang, Xiaoran; Li, Tong; Yu, Jiawei; Parpura, Vladimir; Wang, Yu-Feng

doi:10.1177/17590914221100706

Cited by 59Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyRegulation of Appetite and Obesity

Neural functions of hypothalamic oxytocin and its regulation

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Wang, Ping, Wang, Stephani C., Liu, Xiaoyu, Jia, Shuwei, Wang, Xiaoran, Li, Tong, Yu, Jiawei, Parpura, Vladimir +1 more·2022·ASN Neuro

DOI 10.1177/17590914221100706PMC PMC9125079

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Abstract

Oxytocin (OT), a nonapeptide, has a variety of functions. Despite extensive studies on OT over past decades, our understanding of its neural functions and their regulation remains incomplete. OT is mainly produced in OT neurons in the supraoptic nucleus (SON), paraventricular nucleus (PVN) and accessory nuclei between the SON and PVN. OT exerts neuromodulatory effects in the brain and spinal cord. While magnocellular OT neurons in the SON and PVN mainly innervate the pituitary and forebrain regions, and parvocellular OT neurons in the PVN innervate brainstem and spinal cord, the two sets of OT neurons have close interactions histologically and functionally. OT expression occurs at early life to promote mental and physical development, while its subsequent decrease in expression in later life stage accompanies aging and diseases. Adaptive changes in this OT system, however, take place under different conditions and upon the maturation of OT release machinery. OT can modulate social recognition and behaviors, learning and memory, emotion, reward, and other higher brain functions. OT also regulates eating and drinking, sleep and wakefulness, nociception and analgesia, sexual behavior, parturition, lactation and other instinctive behaviors. OT regulates the autonomic nervous system, and somatic and specialized senses. Notably, OT can have different modulatory effects on the same function under different conditions. Such divergence may derive from different neural connections, OT receptor gene dimorphism and methylation, and complex interactions with other hormones. In this review, brain functions of OT and their underlying neural mechanisms as well as the perspectives of their clinical usage are presented.

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Certain brain regions such as the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus have been identified as essential components concerning social behaviour.
“Certain brain regions such as the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of the hypothalamus have been identified as essential components concerning social behaviour (Wang et al., 2022).”
From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Wang et al., 2022

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The role of oxytocin in delay of gratification and flexibility in non-social decision making
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Endogenous Gustatory Responses and Gene Expression Profile of Stably Proliferating Human Taste Cells Isolated From Fungiform Papillae
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Cocaine abstinence induces emotional impairment and brain region‐specific upregulation of the oxytocin receptor binding
Georgiou, P., Zanos, P., Hourani, S. M. O., Kitchen, I., & Bailey, A. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13348 · Cited by 33 · see citing works
Intranasal oxytocin increases respiratory rate and reduces obstructive event duration and oxygen desaturation in obstructive sleep apnea patients: a randomized double blinded placebo controlled study
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Oxytocin enhances presynaptic and postsynaptic glutamatergic transmission between rat olfactory bulb neurones in culture
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Model Roles of the Hypothalamo-Neurohypophysial System in Neuroscience Study
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Transport of oxytocin to the brain after peripheral administration by membrane‐bound or soluble forms of receptors for advanced glycation end‐products
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Salivary oxytocin, cognitive anxiety and self-confidence in pre-competition athletes
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Hypothalamic Endothelin
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Wong S. F. Cardoso C. Orlando M. A. Brown C. A. Ellenbogen M. A. (2021b). Depressive symptoms and social context modulate oxytocin’s effect on negative memory recall. Social Cognitive and Affective Neuroscience. PMC8717011 34100542

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Authors: Wang, P., Wang, S. C., Liu, X., Jia, S., Wang, X., Li, T., Yu, J., Parpura, V., & Wang, Y.-F.
Affiliations: Harbin Medical University (CN)
University of California, Irvine (US)
University of Alabama at Birmingham (US)
Corresponding author: Parpura, Vladimir
Wang, Yu-Feng
ORCID: Wang, Ping
Wang, Stephani C.
Liu, Xiaoyu
Wang, Xiaoran
Li, Tong
Parpura, Vladimir
Wang, Yu-Feng
Venue: ASN Neuro
Publisher: Informa UK Limited
Published: 2022-01
Volume: 14
Issue: 1
Pages: 17590914221100706-17590914221100706
ISSN: 1759-0914 (ISSN-L)
DOI: 10.1177/17590914221100706
PMC: PMC9125079
OpenAlex: W4281254264
Cited by: 59
References: 311
Citations by year: 2026: 13 · 2025: 11 · 2024: 14 · 2023: 17 · 2022: 4
FWCI: 1.72
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/4.0/ (vor)
Locations: ASN NEURO (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Fund of the Ministry of Science and Technology of China (G2021011014L)
National Institute of General Medical Sciences of the National Institutes of Health (R01GM123971)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: oxytocin, hypothalamus, supraoptic nucleus, paraventricular nucleus, magnocellular neurons, parvocellular neurons, neuromodulation, social behavior, learning and memory, emotions, reward, sleep and wakefulness, sexual behavior, autonomic nervous system, DNA methylation, hormone crosstalk, aging
MeSH terms: Female, Humans, Hypothalamus, Neurons, Oxytocin, Paraventricular Hypothalamic Nucleus, Supraoptic Nucleus

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Neural functions of hypothalamic oxytocin and its regulation

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