Cited by 35Nursing care and researchCancer survivorship and careGlioma Diagnosis and Treatment

Caregiver burden by treatment and clinical characteristics of patients with glioblastoma

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Au, Trang H., Willis, Connor, Reblin, Maija, Peters, Katherine B., Nghiemphu, Phioanh Leia, Taylor, Jennie W., Colman, Howard, Cohen, Adam L. +13 more·2022·Supportive Care in Cancer

Abstract

Background: Glioblastoma is an incurable disease with a poor prognosis. For caregivers of people with glioblastoma, the burden of care can be high. Patients often present with different clinical characteristics, which may impact caregiver burden in different ways. This study aimed to evaluate associations between patient clinical characteristics and caregiver burden/quality of life (QoL). Methods: Caregiver–patient dyads were enrolled at 7 academic cancer centers in the United States. Eligible caregiver participants were self-reported as the primary caregiver of an adult living with glioblastoma and completed a caregiver burden survey. Eligible patients were age ≥ 18 years at glioblastoma diagnosis and alive when their respective caregiver entered the study, with the presence of cognitive dysfunction confirmed by the caregiver. Data were analyzed with descriptive statistics and multivariable analyses. Results: The final cohort included 167 dyads. Poor patient performance status resulted in patient difficulty with mental tasks, more caregiving tasks, and increased caregiving time. Language problems were reported in patients with left-sided lesions. Patient confusion was negatively associated with all caregiver domains: emotional health, social health, general health, ability to work, confidence in finances, and overall QoL. Better caregiver QoL was observed in patients with frontal lobe lesions versus non-frontal lobe lesions. Conclusion: This study reinforced that patient performance status is a critical clinical factor that significantly affects caregiver burden, caregiving tasks, and caregiver time. Additionally, patient confusion affects multiple facets of caregiver burden/QoL. These results could be used to support guided intervention for caregiver support, customized to the patient experience.

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  • Similar work in glioblastoma caregivers has highlighted that burden is not uniform across clinical settings and might vary according to treatment phase and patient clinical characteristics.

    “Similar work in glioblastoma caregivers has also highlighted that burden is not uniform across clinical settings and might vary according to treatment phase and patient clinical characteristics.10”

    From Caregiver burden, quality of life, and psychosocial outcomes among informal caregivers of patients with glioma: A systematic review and meta-analysis (2026) · cites this paper as [10]

    The Results and Conclusion report that caregiver burden differs with patient clinical characteristics, including performance status and confusion. The Patient demographics section includes caregivers at different treatment stages, but the paper does not establish that burden varies by treatment phase; its Discussion notes that the one-time survey cannot reflect changes over the course of caregiving. No page numbers were available in our copy. (LLM, conf=0.86)

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  • The pooled burden prevalence in this review is broadly consistent with prior neuro-oncology literature, while the heterogeneity mirrors the diversity of caregiving contexts previously described.

    “The pooled burden prevalence in this review is broadly consistent with that literature, while the heterogeneity mirrors the diversity of caregiving contexts previously described.10,27”

    From Caregiver burden, quality of life, and psychosocial outcomes among informal caregivers of patients with glioma: A systematic review and meta-analysis (2026) · cites this paper as [10]

    The Conclusion (page unavailable) says that glioblastoma caregiver–patient dyads are not all alike, and the Discussion describes differences in caregiver experience linked to patient characteristics. This supports the point about diverse caregiving contexts. The paper does not compare this review’s pooled burden prevalence with prior literature or assess the review’s statistical heterogeneity. (LLM, conf=0.86)

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  • Empirical studies in patients with glioma suggest that caregiver burden is common and clinically meaningful.

    “Empirical studies in patients with glioma suggest that caregiver burden is common and clinically meaningful.6, 7, 8, 9, 10”

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Authors
Au, T. H., Willis, C., Reblin, M., Peters, K. B., Nghiemphu, P. L., Taylor, J. W., Colman, H., Cohen, A. L., Ormond, D. R., Chakravarti, A., Willmarth, N., Menon, J., Ma, J., Bauer, H., Watanabe, A. H., Ulrich, C. M., Singh, P., Marshall, A., Korytowsky, B., Stenehjem, D., & Brixner, D.
Affiliations
  • University of Utah (US)
  • Moffitt Cancer Center (US)
  • Duke Medical Center (US)
  • University of California, Los Angeles (US)
  • University of California, San Francisco (US)
  • University of Colorado Anschutz (US)
  • The Ohio State University (US)
  • American Brain Tumor Association (US)
  • Bristol-Myers Squibb (United States) (US)
Corresponding author
Brixner, Diana
Venue
Supportive Care in Cancer
Published
2021-09-11
Volume
30
Issue
2
Pages
1365-1375
ISSN
  • 0941-4355 (ISSN-L)
  • 1433-7339
OpenAlex
W3201427233
Cited by
34
References
40
Citations by year
2026: 4 · 2025: 13 · 2024: 11 · 2023: 4 · 2022: 2
FWCI
6.63
Type
journal article
Language
en
Open access
Locations
  • Supportive Care in Cancer (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
Bristol Myers Squibb
Topics
  • Health Sciences › Health Professions › Pharmacy › Nursing care and research
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
Keywords
glioblastoma, caregiver burden, caregiver quality of life, performance status, cognitive impairment, patient confusion, language difficulties, frontal lobe lesions, caregiving responsibilities, caregiver time, caregiver support
MeSH terms
Caregiver Burden, Adolescent, Adult, Glioblastoma, Humans, Quality of Life, Surveys and Questionnaires, Caregivers, Cost of Illness

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