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Evidence-based clinical practice guidelines for irritable bowel syndrome 2020

Fukudo, Shin, Okumura, Toshikatsu, Inamori, Masahiko, Okuyama, Yusuke, Kanazawa, Motoyori, Kamiya, Takeshi, Sato, Ken, Shiotani, Akiko, Naito, Yuji, Fujikawa, Yoshiko, Hokari, Ryota, Masaoka, Tastuhiro, Fujimoto, Kazuma, Kaneko, Hiroshi, Torii, Akira, Matsueda, Kei, Miwa, Hiroto, Enomoto, Nobuyuki, Shimosegawa, Tooru, Koike, Kazuhiko·2021·Journal of Gastroenterology
DOI 10.1007/s00535-020-01746-z
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Abstract

Managing irritable bowel syndrome (IBS) has attracted international attention because single-agent therapy rarely relieves bothersome symptoms for all patients. The Japanese Society of Gastroenterology (JSGE) published the first edition of evidence-based clinical practice guidelines for IBS in 2015. Much more evidence has accumulated since then, and new pharmacological agents and non-pharmacological methods have been developed. Here, we report the second edition of the JSGE-IBS guidelines comprising 41 questions including 12 background questions on epidemiology, pathophysiology, and diagnostic criteria, 26 clinical questions on diagnosis and treatment, and 3 questions on future research. For each question, statements with or without recommendations and/or evidence level are given and updated diagnostic and therapeutic algorithms are provided based on new evidence. Algorithms for diagnosis are requisite for patients with chronic abdominal pain or associated symptoms and/or abnormal bowel movement. Colonoscopy is indicated for patients with one or more alarm symptoms/signs, risk factors, and/or abnormal routine examination results. The diagnosis is based on the Rome IV criteria. Step 1 therapy consists of diet therapy, behavioral modification, and gut-targeted pharmacotherapy for 4 weeks. For non-responders, management proceeds to step 2 therapy, which includes a combination of different mechanistic gut-targeted agents and/or psychopharmacological agents and basic psychotherapy for 4 weeks. Step 3 therapy is for non-responders to step 2 and comprises a combination of gut-targeted pharmacotherapy, psychopharmacological treatments, and/or specific psychotherapy. These updated JSGE-IBS guidelines present best practice strategies for IBS patients in Japan and we believe these core strategies can be useful for IBS diagnosis and treatment globally.

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Metadata

Authors
Fukudo, S., Okumura, T., Inamori, M., Okuyama, Y., Kanazawa, M., Kamiya, T., Sato, K., Shiotani, A., Naito, Y., Fujikawa, Y., Hokari, R., Masaoka, T., Fujimoto, K., Kaneko, H., Torii, A., Matsueda, K., Miwa, H., Enomoto, N., Shimosegawa, T., & Koike, K.
ORCID
Fukudo, Shin
Venue
Journal of Gastroenterology
Publisher
Springer Science and Business Media LLC
Published
2021-02-04
Volume
56
Issue
3
Pages
193-217
ISSN
  • 0944-1174
  • 1435-5922
DOI
10.1007/s00535-020-01746-z
Cited by
163
References
51
Language
en
Update notices
correction (2023-09-26)
Licence

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CoChat. (2026). Citation check: Evidence-based clinical practice guidelines for irritable bowel syndrome 2020. https://app.cochat.ai/papers/10.1007/s00535-020-01746-z
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Fukudo, S., Okumura, T., Inamori, M., Okuyama, Y., Kanazawa, M., Kamiya, T., Sato, K., Shiotani, A., Naito, Y., Fujikawa, Y., Hokari, R., Masaoka, T., Fujimoto, K., Kaneko, H., Torii, A., Matsueda, K., Miwa, H., Enomoto, N., Shimosegawa, T., & Koike, K. (2021). Evidence-based clinical practice guidelines for irritable bowel syndrome 2020. Journal of Gastroenterology. https://doi.org/10.1007/s00535-020-01746-z

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