Glia and volume transmission during physiological and pathological states
Abstract
Extrasynaptic communication between neurons or neurons and glia is mediated by the diffusion of neuroactive substances through the extracellular space (ECS). Structural changes and amino acid release occurring under physiological and pathological conditions result in cellular (particularly glial) swelling, leading to dynamic changes in the ECS volume and geometry that in turn affect ECS diffusion. Significant changes in ECS volume and in diffusion barriers occur during development and aging. They are often the result of cell death, astrogliosis, the rearrangement of astrocytic processes and changes in extracellular matrix molecules. Plastic changes in ECS volume, geometry and anisotropy significantly affect the spatial relation of glial processes towards synapses, glutamate or GABA 'spillover', synaptic cross-talk and neuron-glia communication/interaction. In addition, changes occurring during pathological states can be important for diagnosis, drug delivery and treatment.
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Extracellular diffusion depends on ECM structure and chemical properties.
“Because diffusion in the extracellular space is dependent on the structure and chemical properties of the ECM (Sykova, 2005)”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Sykova, 2005
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Hess, E. M., Madayag, A., Hearing, M. C., & Baker, D. L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812202-0.00016-6 · Cited by 1 · see citing works
Imaging dynamic volume changes in astrocytes
Florence, C. M. (2010) · University Library - University of Saskatchewan (University of Saskatchewan)
Theoretische Untersuchungen zur Kopplung von neuronaler Erregung und neuronalem Energiestoffwechsel
Berndt, N. (2012) · edoc Publication server (Humboldt University of Berlin) · doi:10.18452/16668
fractal based model of diffusion MRI in cortical grey matter
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Ranepura, N. (2011) · QSpace (Queen's University Library)
Sleep, Adenosine, and Neurodegeneration
Bjorness, T. E., & Greene, R. W. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803724-9.00006-5
Astrocytes Store for Memory and Cognition
Baghmaleki, M. K. (2021) · Neuroscience International · doi:10.3844/amjnsp.2021.4.7
Robert, J., Drown, C., & Gertz, M. L. (2011) · InTech eBooks · doi:10.5772/19517
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Rôle de la D-sérine dans la modulation des synapses glutamatergiques de l'hippocampe
Bail, M. L. (2015) · theses.fr (ABES) · doi:10.70675/e5c5af98zfa6az4f78zb04fzc23c8de05a70
- Authors
- Sykov�, E.
- Affiliations
- Czech Academy of Sciences (CZ)
- Corresponding author
- Sykov�, E.
- Venue
- Journal of Neural Transmission
- Published
- 2004-03-19
- Volume
- 112
- Issue
- 1
- Pages
- 137-147
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- OpenAlex
- W2098922689
- Cited by
- 85
- References
- 36
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 5 · 2014: 4 · 2013: 2 · 2012: 6
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neural Transmission (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Grantová Agentura České Republiky
- Akademie Věd České Republiky
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- glia, volume transmission, extracellular space, glial swelling, amino acid release, astrocytes, astrocyte activation, extracellular matrix, glutamate spillover, neuron-glia communication, aging, development (biology), cell death, drug delivery
- MeSH terms
- Aging, Animals, Brain, Cell Communication, Diffusion, Extracellular Space, Humans, Synaptic Transmission, Neuroglia
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