Cited by 85Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration MechanismsBarrier Structure and Function Studies

Glia and volume transmission during physiological and pathological states

Sykov�, E.·2005·Journal of Neural Transmission

Abstract

Extrasynaptic communication between neurons or neurons and glia is mediated by the diffusion of neuroactive substances through the extracellular space (ECS). Structural changes and amino acid release occurring under physiological and pathological conditions result in cellular (particularly glial) swelling, leading to dynamic changes in the ECS volume and geometry that in turn affect ECS diffusion. Significant changes in ECS volume and in diffusion barriers occur during development and aging. They are often the result of cell death, astrogliosis, the rearrangement of astrocytic processes and changes in extracellular matrix molecules. Plastic changes in ECS volume, geometry and anisotropy significantly affect the spatial relation of glial processes towards synapses, glutamate or GABA 'spillover', synaptic cross-talk and neuron-glia communication/interaction. In addition, changes occurring during pathological states can be important for diagnosis, drug delivery and treatment.

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Crossref · 10.1007/s00702-004-0120-4

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36 of 36 references verified0 citation errors · 0 not checkable

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Authors
Sykov�, E.
Affiliations
Czech Academy of Sciences (CZ)
Corresponding author
Sykov�, E.
Venue
Journal of Neural Transmission
Published
2004-03-19
Volume
112
Issue
1
Pages
137-147
ISSN
  • 0300-9564 (ISSN-L)
  • 1435-1463
OpenAlex
W2098922689
Cited by
85
References
36
Citations by year
2025: 1 · 2024: 1 · 2022: 1 · 2021: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 5 · 2014: 4 · 2013: 2 · 2012: 6
FWCI
2.23
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neural Transmission (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Grantová Agentura České Republiky
  • Akademie Věd České Republiky
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords
glia, volume transmission, extracellular space, glial swelling, amino acid release, astrocytes, astrocyte activation, extracellular matrix, glutamate spillover, neuron-glia communication, aging, development (biology), cell death, drug delivery
MeSH terms
Aging, Animals, Brain, Cell Communication, Diffusion, Extracellular Space, Humans, Synaptic Transmission, Neuroglia

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