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Evidence for angiogenesis in Parkinson’s disease, incidental Lewy body disease, and progressive supranuclear palsy
Open accessAbstract
Angiogenesis has not been extensively studied in Parkinson's disease (PD) despite being associated with other neurodegenerative disorders. Post-mortem human brain tissues were obtained from subjects with pathologically confirmed Parkinson's disease (PD) and progressive supranuclear palsy (PSP), a rapidly progressing Parkinsonian-like disorder. Tissues were also obtained from subjects with incidental Lewy body disease (iLBD) who had Lewy bodies in the substantia nigra pars compacta (SN(pc)) but had not been diagnosed with PD, and age-matched controls without Lewy body pathology. The SNpc, putamen, locus ceruleus (LC) and midfrontal cortex were examined for integrin αvβ3, a marker for angiogenesis, along with vessel number and activated microglia. All parkinsonian syndromes had greater αvβ3 in the LC and the SN(pc), while only PD and PSP subjects had elevated αvβ3 in the putamen compared to controls. PD and PSP subjects also had increases in microglia number and activation in the SN(pc) suggesting a link between inflammation and clinical disease. Microglia activation in iLBD subjects was limited to the LC, an area involved at an early stage of PD. Likewise, iLBD subjects did not differ from controls in αvβ3 staining in the putamen, a late area of involvement in PD. The presence of αvβ3 reactive vessels in PD and its syndromes is indicative of newly created vessels that have not likely developed the restrictive properties of the blood brain barrier. Such angiogenic vessels could contribute to neuroinflammation by failing to protect the parenchyma from peripheral immune cells and inflammatory or toxic factors in the peripheral circulation.
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“Aberrant angiogenesis is frequently observed in PD patients, as shown in the substantia nigra pars compacta, locus coeruleus, and putamen (144, 627).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [144]
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“Several studies have identified increased microglia number and activation in the substantia nigra pars compacta (SNpc),372 subthalamic nucleus,373 pyramidal, extrapyramidal motor system, and cerebellar output374 of brain tissues from PSP patients by immunochemical postmortem analysis.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [372]
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Metadata
- Authors
- Desai Bradaric, B., Patel, A., Schneider, J. A., Carvey, P. M., & Hendey, B.
- Affiliations
- Rush University (US)
- Corresponding author
- Hendey, Bill
- ORCID
- Schneider, Julie A.
- Venue
- Journal of Neural Transmission
- Published
- 2011-07-12
- Volume
- 119
- Issue
- 1
- Pages
- 59-71
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- PMC
- PMC3352316
- OpenAlex
- W1968306269
- Cited by
- 139
- References
- 90
- Citations by year
- 2026: 10 · 2025: 4 · 2024: 14 · 2023: 10 · 2022: 11 · 2021: 19 · 2020: 13 · 2019: 9 · 2018: 10 · 2017: 5 · 2016: 10 · 2015: 7 · 2014: 10 · 2013: 3 · 2012: 4
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neural Transmission (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P30-AG 10161, R01 AG15819, R01AG015819, P30AG010161, K08AG000849, K08AG000848)
- National Institute of Allergy and Infectious Diseases (R01AI051619, R01AI51619)
- National Institute of Neurological Disorders and Stroke (NS052414, R01NS052414)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- angiogenesis, Parkinson's disease, incidental Lewy body disease, progressive supranuclear palsy, integrin αvβ3, microglial activation, neuroinflammation, blood-brain barrier, locus coeruleus, substantia nigra pars compacta, putamen, Lewy bodies
- MeSH terms
- Aged, Aged, 80 and over, Analysis of Variance, Brain, Female, Humans, Male, Neovascularization, Pathologic, Neurons, Parkinson Disease, Postmortem Changes, Supranuclear Palsy, Progressive, Microglia, Lewy Body Disease, Integrin alphaVbeta3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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