In vivo imaging of microglial activation with [11C](R)‐PK11195 PET in progressive supranuclear palsy
Abstract
Progressive supranuclear palsy (PSP) is a neurodegenerative disease presenting with voluntary gaze difficulties, early falls, and Parkinsonism. Neuronal loss, associated with intracellular neurofibrillary tangles and activated microglia, is found targeting the basal ganglia, brainstem nuclei, and frontal cortex. [11 C](R)‐PK11195 PET is a marker of peripheral benzodiazepine binding sites (PBBS) expressed by activated microglia. We have used [11 C](R)‐PK11195 PET to demonstrate in vivo the degree and distribution of the glial response to the degenerative process in four patients with PSP. Compared to normal age‐matched controls, the PSP patient group showed significantly increased mean [11 C](R)‐PK11195 binding in the basal ganglia, midbrain, the frontal lobe, and the cerebellum. Two of the patients were rescanned after 6 to 10 months and during that time the level of microglial activation remained stable. [11 C](R)‐PK11195 PET reveals a pattern of increased microglial activation in PSP patients involving cortical and subcortical regions that corresponds well with the known distribution of neuropathological changes. [11 C](R)‐PK11195 PET, therefore, may help in characterizing in vivo the underlying disease activity in PSP. © 2005 Movement Disorder Society
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PK-PET is increased in entorhinal, temporal, parietal, and cingulate cortex in AD, in frontotemporal regions in FTD, while PSP shows increased PK-PET binding in thalamus, putamen, and pallidum, showing differential distribution of neuroinflammatory processes in different types of dementia.
“PK-PET is increased in the entorhinal, temporal, parietal and cingulate cortex in AD, in the frontotemporal regions in FTD, while PSP shows increased PK-PET binding in the thalamus, putamen and pallidum, showing differential distribution of neuroinflammatory processes in different types of dementia [215–218].”
From The use of neuroimaging techniques in the early and differential diagnosis of dementia (2023) · cites this paper as [216]
PSP patients showed significantly increased mean [11C](R)-PK11195 binding in the midbrain, basal ganglia, frontal lobe, cerebellum, thalamus, putamen, and globus pallidus compared to controls.
“PSP patients showed significantly increased mean [11C](R)-PK11195 binding in the midbrain, basal ganglia, frontal lobe, cerebellum,375 thalamus, putamen, and globus pallidus376 compared to controls.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [375]
Microglial activation in PSP brains was also detected by PET imaging.
“Microglial activation in PSP brains was also detected by PET imaging.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [375]
Earlier PET investigations have detected alterations in PSP with ligands for tau and for microglial activation.
“Previous positron emission tomography (PET) has indicated changes in PSP using ligands targeting tau8–16 and microglial activation17,18.”
From Neuroinflammation and Tau Colocalize in vivo in Progressive Supranuclear Palsy (2020) · cites this paper as [17]
[11C]PK11195 is commonly employed as an indicator of microglial activation in neurodegenerative conditions, including PSP.
“[11C]PK11195 is widely used as a marker of microglial activation in neurodegenerative diseases23, including PSP17,18.”
From Neuroinflammation and Tau Colocalize in vivo in Progressive Supranuclear Palsy (2020) · cites this paper as [17]
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- Authors
- Gerhard, A., Trender‐Gerhard, I., Turkheimer, F., Quinn, N. P., Bhatia, K. P., & Brooks, D. J.
- Affiliations
- National Hospital for Neurology and Neurosurgery (GB)
- Imperial College London (GB)
- Corresponding author
- Gerhard, Alexander
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2005-08-17
- Volume
- 21
- Issue
- 1
- Pages
- 89-93
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- OpenAlex
- W1965485738
- Cited by
- 171
- References
- 18
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 9 · 2023: 7 · 2022: 5 · 2021: 13 · 2020: 19 · 2019: 14 · 2018: 10 · 2017: 11 · 2016: 12 · 2015: 7 · 2014: 10 · 2013: 10 · 2012: 7
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- progressive supranuclear palsy, microglial activation, [11C]PK11195 PET, neuroinflammation, basal ganglia, midbrain, frontal lobe, cerebellum, neurodegeneration, neurofibrillary tangles
- MeSH terms
- Aged, Basal Ganglia, Brain Stem, Carbon Radioisotopes, Female, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Isoquinolines, Magnetic Resonance Imaging, Male, Middle Aged, Neurons, Radionuclide Imaging, Receptors, GABA-A, Reference Values, Stereoisomerism, Supranuclear Palsy, Progressive, Cell Death, Microglia, Neurodegenerative Diseases
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