Administration of memantine and imipramine alters mitochondrial respiratory chain and creatine kinase activities in rat brain
Abstract
Several studies have appointed for a role of glutamatergic system and/or mitochondrial function in major depression. In the present study, we evaluated the creatine kinase and mitochondrial respiratory chain activities after acute and chronic treatments with memantine (N-methyl-D: -aspartate receptor antagonist) and imipramine (tricyclic antidepressant) in rats. To this aim, rats were acutely or chronically treated for 14 days once a day with saline, memantine (5, 10 and 20 mg/kg) and imipramine (10, 20 and 30 mg/kg). After acute or chronic treatments, we evaluated mitochondrial respiratory chain complexes (I, II, II-III and IV) and creatine kinase activities in prefrontal cortex, hippocampus and striatum. Our results showed that both acute and chronic treatments with memantine or imipramine altered respiratory chain complexes and creatine kinase activities in rat brain; however, these alterations were different with relation to protocols (acute or chronic), complex, dose and brain area. Finally, these findings further support the hypothesis that the effects of imipramine and memantine could be involve mitochondrial function modulation.
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Imipramine treatment increases brain creatine kinase and increases activity of mitochondrial respiratory chain complexes.
“Additionally, imipramine treatment increased brain creatine kinase and increased activity of mitochondrial respiratory chain complexes [18, 53].”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [53]
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- Authors
- Réus, G. Z., Stringari, R. B., Rezin, G. T., Fraga, D. B., Daufenbach, J. F., Scaini, G., Benedet, J., Rochi, N., Streck, E. L., & Quevedo, J.
- Affiliations
- Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (BR)
- Corresponding author
- Quevedo, João
- Venue
- Journal of Neural Transmission
- Published
- 2011-09-28
- Volume
- 119
- Issue
- 4
- Pages
- 481-491
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- OpenAlex
- W2026535009
- Cited by
- 23
- References
- 93
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2016: 1 · 2015: 3 · 2013: 4 · 2012: 2
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neural Transmission (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- memantine, imipramine, mitochondrial respiratory chain, creatine kinase, major depressive disorder, glutamatergic system, NMDA receptor antagonists, tricyclic antidepressants, prefrontal cortex, hippocampus, striatum, mitochondrial function, chronic drug administration
- MeSH terms
- Analysis of Variance, Animals, Brain, Creatine Kinase, Dose-Response Relationship, Drug, Imipramine, Male, Memantine, Multienzyme Complexes, NADH Dehydrogenase, Time Factors, Dopamine Agents, Rats, Wistar, Adrenergic Uptake Inhibitors, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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