Cited by 23Treatment of Major DepressionMitochondrial Function and PathologyNeuroscience and Neuropharmacology Research

Administration of memantine and imipramine alters mitochondrial respiratory chain and creatine kinase activities in rat brain

Réus, Gislaine Z., Stringari, Roberto B., Rezin, Gislaine T., Fraga, Daiane B., Daufenbach, Juliana F., Scaini, Giselli, Benedet, Joana, Rochi, Natália +2 more·2012·Journal of Neural Transmission

Abstract

Several studies have appointed for a role of glutamatergic system and/or mitochondrial function in major depression. In the present study, we evaluated the creatine kinase and mitochondrial respiratory chain activities after acute and chronic treatments with memantine (N-methyl-D: -aspartate receptor antagonist) and imipramine (tricyclic antidepressant) in rats. To this aim, rats were acutely or chronically treated for 14 days once a day with saline, memantine (5, 10 and 20 mg/kg) and imipramine (10, 20 and 30 mg/kg). After acute or chronic treatments, we evaluated mitochondrial respiratory chain complexes (I, II, II-III and IV) and creatine kinase activities in prefrontal cortex, hippocampus and striatum. Our results showed that both acute and chronic treatments with memantine or imipramine altered respiratory chain complexes and creatine kinase activities in rat brain; however, these alterations were different with relation to protocols (acute or chronic), complex, dose and brain area. Finally, these findings further support the hypothesis that the effects of imipramine and memantine could be involve mitochondrial function modulation.

Integrity signals

Registry

Crossref · 10.1007/s00702-011-0718-2

Cites

93 of 93 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Réus, G. Z., Stringari, R. B., Rezin, G. T., Fraga, D. B., Daufenbach, J. F., Scaini, G., Benedet, J., Rochi, N., Streck, E. L., & Quevedo, J.
Affiliations
Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (BR)
Corresponding author
Quevedo, João
Venue
Journal of Neural Transmission
Published
2011-09-28
Volume
119
Issue
4
Pages
481-491
ISSN
  • 0300-9564 (ISSN-L)
  • 1435-1463
OpenAlex
W2026535009
Cited by
23
References
93
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2016: 1 · 2015: 3 · 2013: 4 · 2012: 2
FWCI
1.41
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neural Transmission (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
memantine, imipramine, mitochondrial respiratory chain, creatine kinase, major depressive disorder, glutamatergic system, NMDA receptor antagonists, tricyclic antidepressants, prefrontal cortex, hippocampus, striatum, mitochondrial function, chronic drug administration
MeSH terms
Analysis of Variance, Animals, Brain, Creatine Kinase, Dose-Response Relationship, Drug, Imipramine, Male, Memantine, Multienzyme Complexes, NADH Dehydrogenase, Time Factors, Dopamine Agents, Rats, Wistar, Adrenergic Uptake Inhibitors, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review