From synapse to nucleus: Novel targets for treating depression
Open accessAbstract
The need for newer compounds to treat depression is an ever-growing concern due to the enormous societal and financial ramifications of this disorder. Here, we review some of the candidate systems that could potentially be involved in depression, or an inherent resistance to depression termed resilience, and the numerous protein targets for these systems. A substantial body of literature provides strong evidence that neurotrophic factors, glutamate receptors, hypothalamic feeding peptides, nuclear hormone receptors, and epigenetic mechanisms, among others, will make for interesting targets when examining depressive behavior or resilience in preclinical models, and eventually clinical trials. Although some of these targets for depression already appear promising, new waves of more selective compounds for any molecular system should promote a better understanding of this complex disease and perhaps improved treatments.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The nucleus accumbens and its targets contain potential modulatory drug targets including peptides, growth factors, and other neuromodulatory factors that modify cell firing properties and synaptic transmission.
“The NAc and its targets are littered with potential modulatory drug targets including peptides, growth factors, and other neuromodulatory factors that modify cell firing properties and synaptic transmission (59).”
From Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression (2017) · cites this paper as [59]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177 · see citing works
Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Warden, D., Niederehe, G., Thase, M. E., Lavori, P. W., Lebowitz, B. D., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.11.1905 · Cited by 5,643 · see citing works
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501 · see citing works
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321 · see citing works
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059 · see citing works
Antidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856 · see citing works
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766 · see citing works
THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE
Schildkraut, J. J. (1965) · American Journal of Psychiatry · doi:10.1176/ajp.122.5.509 · Cited by 3,499 · see citing works
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889 · see citing works
Self-citationKrishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · cited 1× · see citing works
“…its nucleus accumbens (NAc) target is triggered by chronic social defeat stress, and this increase is both necessary and sufficient to produce a depressive-like phenotype, while the selective knockout of BDNF from the VTA promotes resilience to stress (Berton et al., 2006; Krishnan et al., 2007).”
BackgroundSelf-citationDrevets, W. C., Price, J. L., & Furey, M. L. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0189-x · Cited by 2,209 · cited 1× · see citing works
“Recent neuroimaging and post-mortem studies of human brain have advanced our knowledge of neural systems involved in depression, particularly brain areas that might underlie cognitive impairments and dysregulation of emotional processing (Drevets et al., 2008).”
BackgroundEssential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
Self-citationThe mesolimbic dopamine reward circuit in depression
Nestler, E. J., & Carlezon, W. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.018 · Cited by 2,059 · see citing works
Self-citationSustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780 · see citing works
Self-citationExtrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
Hardingham, G. E., Fukunaga, Y., & Bading, H. (2002) · Nature Neuroscience · doi:10.1038/nn835 · Cited by 1,686 · see citing works
New approaches to antidepressant drug discovery: beyond monoamines
Berton, O., & Nestler, E. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1846 · Cited by 1,589 · see citing works
Self-citationGould, E., McEwen, B. S., Tanapat, P., Galea, L. A. M., & Fuchs, E. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02492.1997 · Cited by 1,496 · see citing works
Epigenetic regulation in psychiatric disorders
Tsankova, N., Renthal, W., Kumar, A., & Nestler, E. J. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2132 · Cited by 1,400 · see citing works
Self-citationCarlezon, W. A., Duman, R. S., & Nestler, E. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.005 · Cited by 1,351 · see citing works
Self-citationWhy stress is bad for your brain
Sapolsky, R. M. (1996) · Science · doi:10.1126/science.273.5276.749 · Cited by 1,306 · cited 2× · see citing works
“reported in depressed humans and after chronic stress in animal models (Gould et al., 1997; Sapolsky, 1996).”
BackgroundPsychobiology and molecular genetics of resilience
Feder, A., Nestler, E. J., & Charney, D. S. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2649 · Cited by 1,272 · see citing works
Self-citationNew insights into BDNF function in depression and anxiety
Martinowich, K., Manji, H., & Lu, B. (2007) · Nature Neuroscience · doi:10.1038/nn1971 · Cited by 1,221 · see citing works
The cellular neurobiology of depression
Manji, H. K., Drevets, W. C., & Charney, D. S. (2001) · Nature Medicine · doi:10.1038/87865 · Cited by 1,182 · see citing works
Dynamic DNA methylation programs persistent adverse effects of early-life stress
Murgatroyd, C., Patchev, A. V., Wu, Y., Micale, V., Bockmühl, Y., Fischer, D., Holsboer, F., Wotjak, C. T., Almeida, O. F. X., & Spengler, D. (2009) · Nature Neuroscience · doi:10.1038/nn.2436 · Cited by 1,162 · see citing works
Maeng, S., Zarate, C. A., Du, J., Schloesser, R. J., McCammon, J., Chen, G., & Manji, H. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.028 · Cited by 1,103 · see citing works
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
Jeffrey Conn, P., Christopoulos, A., & Lindsley, C. W. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2760 · Cited by 1,063 · see citing works
Deep Brain Stimulation to Reward Circuitry Alleviates Anhedonia in Refractory Major Depression
Schlaepfer, T. E., Cohen, M. X., Frick, C., Kosel, M., Brodesser, D., Axmacher, N., Joe, A. Y., Kreft, M., Lenartz, D., & Sturm, V. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301408 · Cited by 1,027 · see citing works
Synaptic AMPA receptor plasticity and behavior
Kessels, H. W., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.015 · Cited by 993 · see citing works
Freeman, E. W., Sammel, M. D., Lin, H., & Nelson, D. B. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.4.375 · Cited by 904 · see citing works
Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders
Sanacora, G., Zarate, C. A., Krystal, J. H., & Manji, H. K. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2462 · Cited by 894 · see citing works
The Descriptive Epidemiology of Commonly Occurring Mental Disorders in the United States
Kessler, R. C., & Wang, P. S. (2008) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.29.020907.090847 · Cited by 888 · see citing works
Dwivedi, Y., Rizavi, H. S., Conley, R. R., Roberts, R. C., Tamminga, C. A., & Pandey, G. N. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.804 · Cited by 875 · see citing works
Risk for New Onset of Depression During the Menopausal Transition
Cohen, L. S., Soares, C. N., Vitonis, A. F., Otto, M. W., & Harlow, B. L. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.4.385 · Cited by 836 · see citing works
Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
Woo, N. H., Teng, H. K., Siao, C.-J., Chiaruttini, C., Pang, P. T., Milner, T. A., Hempstead, B. L., & Lu, B. (2005) · Nature Neuroscience · doi:10.1038/nn1510 · Cited by 815 · see citing works
Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression
aan het Rot, M., Collins, K. A., Murrough, J. W., Perez, A. M., Reich, D. L., Charney, D. S., & Mathew, S. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.038 · Cited by 690 · see citing works
Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity
Yashiro, K., & Philpot, B. D. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.046 · Cited by 649 · see citing works
The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress
Lutter, M., Sakata, I., Osborne-Lawrence, S., Rovinsky, S. A., Anderson, J. G., Jung, S., Birnbaum, S., Yanagisawa, M., Elmquist, J. K., Nestler, E. J., et al. (2008) · Nature Neuroscience · doi:10.1038/nn.2139 · Cited by 644 · see citing works
Self-citationAntidepressant Actions of Histone Deacetylase Inhibitors
Covington, H. E., Maze, I., LaPlant, Q. C., Vialou, V. F., Ohnishi, Y. N., Berton, O., Fass, D. M., Renthal, W., Rush, A. J., Wu, E. Y., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1758-09.2009 · Cited by 624 · see citing works
Self-citationHomeostatic and hedonic signals interact in the regulation of food intake
Lutter, M., & Nestler, E. J. (2009) · The Journal of Nutrition · doi:10.3945/jn.108.097618 · Cited by 614 · see citing works
Self-citationDnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
LaPlant, Q., Vialou, V., Covington, H. E., Dumitriu, D., Feng, J., Warren, B. L., Maze, I., Dietz, D. M., Watts, E. L., Iñiguez, S. D., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2619 · Cited by 612 · see citing works
Self-citationPrice, R. B., Nock, M. K., Charney, D. S., & Mathew, S. J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.029 · Cited by 600 · see citing works
5-HT1A receptor function in major depressive disorder
Savitz, J. B., Lucki, I., & Drevets, W. C. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.01.009 · Cited by 573 · see citing works
Transdermal oestrogen for treatment of severe postnatal depression
Grégoire, A., Kumar, R., Everitt, B. J., & Studd, J. W. W. (1996) · The Lancet · doi:10.1016/s0140-6736(96)91414-2 · Cited by 559 · see citing works
Antidepressant-Like Effects of the Histone Deacetylase Inhibitor, Sodium Butyrate, in the Mouse
Schroeder, F. A., Lin, C. L., Crusio, W. E., & Akbarian, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.036 · Cited by 541 · see citing works
Tomita, S., Chen, L., Kawasaki, Y., Petralia, R. S., Wenthold, R. J., Nicoll, R. A., & Bredt, D. S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200212116 · Cited by 527 · see citing works
Gatt, J. M., Nemeroff, C. B., Dobson-Stone, C., Paul, R. H., Bryant, R. A., Schofield, P. R., Gordon, E., Kemp, A. H., & Williams, L. M. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.143 · Cited by 525 · see citing works
Preskorn, S., Baker, B., Kolluri, S., Menniti, F. S., Krams, M., & Landen, J. W. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31818a6cea · Cited by 522 · see citing works
Minowada, G., Jarvis, L. A., Chi, C. L., Neubüser, A., Sun, X., Hacohen, N., Krasnow, M. A., & Martin, G. R. (1999) · Development · doi:10.1242/dev.126.20.4465 · Cited by 506 · see citing works
Monteggia, L. M., Luikart, B., Barrot, M., Theobold, D., Malkovska, I., Nef, S., Parada, L. F., & Nestler, E. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.021 · Cited by 502 · see citing works
Self-citationManji, H. K., Quiroz, J. A., Sporn, J., Payne, J. L., Denicoff, K. D., Gray, N. A., Zarate, C. A., & Charney, D. S. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00117-3 · Cited by 499 · see citing works
Neurobiological mechanisms in major depressive disorder
Rot, M. A. H., Mathew, S. J., & Charney, D. S. (2009) · Canadian Medical Association Journal · doi:10.1503/cmaj.080697 · Cited by 473 · see citing works
VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants
Warner-Schmidt, J. L., & Duman, R. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610282104 · Cited by 438 · see citing works
Histone H3 Lysine 4 Demethylation Is a Target of Nonselective Antidepressive Medications
Lee, M. G., Wynder, C., Schmidt, D. M., McCafferty, D. G., & Shiekhattar, R. (2006) · Chemistry & Biology · doi:10.1016/j.chembiol.2006.05.004 · Cited by 438 · see citing works
Dysregulation of the fibroblast growth factor system in major depression
Evans, S. J., Choudary, P. V., Neal, C. R., Li, J. Z., Vawter, M. P., Tomita, H., Lopez, J. F., Thompson, R. C., Meng, F., Stead, J. D., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406788101 · Cited by 424 · see citing works
Feyissa, A. M., Chandran, A., Stockmeier, C. A., & Karolewicz, B. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.10.005 · Cited by 421 · see citing works
Eisch, A. J., Bolaños, C. A., de Wit, J., Simonak, R. D., Pudiak, C. M., Barrot, M., Verhaagen, J., & Nestler, E. J. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.08.003 · Cited by 420 · see citing works
Self-citationFibroblast growth factors and their receptors in the central nervous system
Reuß, B., & Halbach, O. V. B. U. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0756-7 · Cited by 412 · see citing works
Is it time to reassess the BDNF hypothesis of depression?
Groves, J. O. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002075 · Cited by 403 · see citing works
Functional Proteomics Identify Cornichon Proteins as Auxiliary Subunits of AMPA Receptors
Schwenk, J., Harmel, N., Zolles, G., Bildl, W., Kulik, Á., Heimrich, B., Chisaka, O., Jónás, P., Schulte, U., Fakler, B., et al. (2009) · Science · doi:10.1126/science.1167852 · Cited by 388 · see citing works
Georgescu, D., Sears, R. M., Hommel, J. D., Barrot, M., Bolaños, C. A., Marsh, D. J., Bednarek, M. A., Bibb, J. A., Maratos–Flier, E., Nestler, E. J., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1714-04.2005 · Cited by 346 · see citing works
Self-citationPDE4 inhibitors: current status
Spina, D. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.307 · Cited by 342 · see citing works
A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant Treatment
Duman, C. H., Schlesinger, L., Kodama, M., Russell, D., & Duman, R. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.047 · Cited by 338 · see citing works
An Open-Label Trial of Riluzole in Patients With Treatment-Resistant Major Depression
Zarate, C. A., Payne, J. L., Quiroz, J. A., Sporn, J., Denicoff, K. K., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.1.171 · Cited by 324 · see citing works
Sapolsky, R. M. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0350 · Cited by 316 · see citing works
Porter, R. H. P., Jaeschke, G., Spooren, W., Ballard, T. M., Büttelmann, B., Kolczewski, S., Peters, J.-U., Prinssen, E., Wichmann, J., Vieira, E., et al. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.089839 · Cited by 308 · see citing works
Zagrebelsky, M., Holz, A., Dechant, G., Barde, Y.-A., Bonhoeffer, T., & Korte, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2492-05.2005 · Cited by 286 · see citing works
Role of S-adenosyl-l-methionine in the treatment of depression: a review of the evidence,,,
Mischoulon, D., & Fava, M. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.5.1158s · Cited by 285 · see citing works
Increased anxiety and synaptic plasticity in estrogen receptor β-deficient mice
Krężel, W., Dupont, S., Krust, A., Chambon, P., & Chapman, P. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221451898 · Cited by 279 · see citing works
Cryan, J. F., Kelly, P. H., Neijt, H. C., Sansig, G., Flor, P. J., & van der Putten, H. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02667.x · Cited by 266 · see citing works
Maternal care, the epigenome and phenotypic differences in behavior
Moshe Szyf, A., Weaver, I. C. G., & Meaney, M. J. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.05.001 · Cited by 263 · see citing works
Estrogen Deficiency in Severe Postpartum Depression
Ahokas, A., Kaukoranta, J., Wahlbeck, K., & Aito, M. (2001) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v62n0504 · Cited by 261 · see citing works
Volosin, M., Song, W., Almeida, R. D., Kaplan, D. R., Hempstead, B. L., & Friedman, W. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1560-06.2006 · Cited by 259 · see citing works
Weight regulation in normal and hypothalamic hyperphagic rats.
Hoebel, B. G., & Teitelbaum, P. (1966) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0023126 · Cited by 258 · see citing works
Stargazin Reduces Desensitization and Slows Deactivation of the AMPA-Type Glutamate Receptors
Priel, A., Kolleker, A., Ayalon, G., Gillor, M., Osten, P., & Stern-Bach, Y. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4834-04.2005 · Cited by 249 · see citing works
Orexin Signaling Mediates the Antidepressant-Like Effect of Calorie Restriction
Lutter, M., Krishnan, V., Russo, S. J., Jung, S., McClung, C. A., & Nestler, E. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5584-07.2008 · Cited by 234 · see citing works
Self-citationSprouty proteins, masterminds of receptor tyrosine kinase signaling
Cabrita, M. A., & Christofori, G. (2008) · Angiogenesis · doi:10.1007/s10456-008-9089-1 · Cited by 231 · see citing works
Walf, A. A., & Frye, C. A. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300713 · Cited by 229 · see citing works
Zhang, H. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00344-5 · Cited by 228 · see citing works
Imwalle, D. B., Gustafsson, J.-Α., & Rissman, E. F. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.11.002 · Cited by 225 · see citing works
Heine, V. M., Zareno, J., Maslam, S., Joëls, M., & Lucassen, P. J. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03951.x · Cited by 225 · see citing works
Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition
Mott, D. D., Doherty, J., Zhang, S., Washburn, M. S., Fendley, M. J., Lyuboslavsky, P. N., Traynelis, S. F., & Dingledine, R. J. (1998) · Nature Neuroscience · doi:10.1038/3661 · Cited by 224 · see citing works
A Transmembrane Accessory Subunit that Modulates Kainate-Type Glutamate Receptors
Zhang, W., St-Gelais, F., Grabner, C. P., Trinidad, J. C., Sumioka, A., Morimoto‐Tomita, M., Kim, K. S., Straub, C., Burlingame, A. L., Howe, J. R., et al. (2009) · Neuron · doi:10.1016/j.neuron.2008.12.014 · Cited by 223 · see citing works
Novel Drugs and Therapeutic Targets for Severe Mood Disorders
Mathew, S. J., Manji, H. K., & Charney, D. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301652 · Cited by 222 · see citing works
Genetic Markers of Suicidal Ideation Emerging During Citalopram Treatment of Major Depression
Laje, G., Paddock, S., Manji, H. K., Rush, A. J., Wilson, A. F., Charney, D. S., & McMahon, F. J. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06122018 · Cited by 213 · see citing works
Role of S-adenosyl-l-methionine in the treatment of depression: a review of the evidence,,,
Mischoulon, D., & Fava, M. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76/5.1158s · Cited by 212 · see citing works
The NMDA Receptor as a Therapeutic Target in Major Depressive Disorder
Pittenger, C., Sanacora, G., & Krystal, J. H. (2007) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152707780363267 · Cited by 203 · see citing works
The varied clinical presentations of major depressive disorder.
Rush, A. J. (2007) · PubMed · Cited by 200 · see citing works
Role of the hypothalamus in the regulation of food and water intake.
Grossman, S. P. (1975) · Psychology Review · doi:10.1037/0033-295x.82.3.200 · Cited by 193 · see citing works
Association of GRIK4 With Outcome of Antidepressant Treatment in the STAR*D Cohort
Paddock, S., Laje, G., Charney, D. S., Rush, A. J., Wilson, A. F., Sorant, A. J. M., Lipsky, R. H., Wisniewski, S. R., Manji, H., & McMahon, F. J. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06111790 · Cited by 192 · see citing works
Alteration in the Hypothalamic-Pituitary-Ovarian Axis in Depressed Women
Young, E. A., MIDGLEY, A. R., Carlson, N. E., & Brown, M. B. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.12.1157 · Cited by 187 · see citing works
Reduced anxiety and improved stress coping ability in mice lacking NPY‐Y2 receptors
Tschenett, A., Singewald, N., Carli, M., Balducci, C., Salchner, P., Vezzani, A., Herzog, H., & Sperk, G. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02725.x · Cited by 180 · see citing works
Krishnan, V., Han, M.-H., Mazei-Robison, M., Iñiguez, S. D., Ables, J. L., Vialou, V., Berton, O., Ghose, S., Covington, H. E., Wiley, M. D., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.003 · Cited by 176 · see citing works
Self-citationGlutamate metabotropic receptors as targets for drug therapy in epilepsy
Moldrich, R. X., Chapman, A. G., Sarro, G. D., et al. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)02149-6 · Cited by 170 · see citing works
Sex differences in psychiatric disorders: origins and developmental influences.
Earls, F. J. (1987) · PubMed · Cited by 167 · see citing works
Association of GRIK4 With Outcome of Antidepressant Treatment in the STAR*D Cohort
Ballenger, J. C. (2009) · Yearbook of Psychiatry and Applied Mental Health · doi:10.1016/s0084-3970(08)79086-8 · Cited by 167 · see citing works
Walf, A., & Frye, C. (2007) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2006.07.003 · Cited by 166 · see citing works
Mood disorders: Regulation by metabotropic glutamate receptors
Pilc, A., Chaki, S., Nowak, G., & Witkin, J. M. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.09.021 · Cited by 163 · see citing works
Metabotropic Glutamate 5 Receptor Antagonism Is Associated with Antidepressant-Like Effects in Mice
Li, X., Need, A. B., Baez, M., & Witkin, J. M. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.103143 · Cited by 163 · see citing works
Hiroi, R., McDevitt, R. A., & Neumaier, J. F. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.019 · Cited by 161 · see citing works
Properties and Functions of GAF Domains in Cyclic Nucleotide Phosphodiesterases and Other Proteins
Zoraghi, R., Corbin, J. D., & Francis, S. H. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.2.267 · Cited by 160 · see citing works
Lodge, D. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.006 · Cited by 158 · see citing works
Reduced Neuropeptide Y Concentrations in Suicide Brain
Widdowson, P. S., Ordway, G. A., & Halaris, A. E. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb08877.x · Cited by 155 · see citing works
GAF Domains: Two-Billion-Year-Old Molecular Switches that Bind Cyclic Nucleotides
Martinez, S. E. (2002) · Molecular Interventions · doi:10.1124/mi.2.5.317 · Cited by 150 · see citing works
Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than “depressive”
Zörner, B., Wolfer, D. P., Brandis, D., Kretz, O., Zacher, C., Madani, R., Kadow, I. C. G., Lipp, H., Klein, R., Henn, F. A., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00418-9 · Cited by 145 · see citing works
AMPA receptor subunit 1 (GluR‐A) knockout mice model the glutamate hypothesis of depression
Chourbaji, S., Vogt, M. A., Fumagalli, F., Sohr, R., Frasca, A., Brandwein, C., Hörtnagl, H., Riva, M. A., Sprengel, R., & Gass, P. (2008) · The FASEB Journal · doi:10.1096/fj.08-106450 · Cited by 144 · see citing works
Elevated levels of NR2A and PSD-95 in the lateral amygdala in depression
Karolewicz, B., Szebeni, K., Gilmore, T., Maciąg, D., Stockmeier, C. A., & Ordway, G. A. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708008985 · Cited by 144 · see citing works
Regulation of AMPA receptor gating and pharmacology by TARP auxiliary subunits
Milstein, A. D., & Nicoll, R. A. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.04.004 · Cited by 132 · see citing works
CYLOSERINE AS AN ANTIDEPRESSANT AGENT
CRANE, G. E. (1959) · American Journal of Psychiatry · doi:10.1176/ajp.115.11.1025 · Cited by 127 · see citing works
Antidepressant-like effects of intracerebroventricular FGF2 in rats
Turner, C. A., Gula, E. L., Taylor, L. P., Watson, S. J., & Akil, H. (2008) · Brain Research · doi:10.1016/j.brainres.2008.05.088 · Cited by 125 · see citing works
Dwivedi, Y., Rizavi, H. S., Conley, R. R., & Pandey, G. N. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001744 · Cited by 123 · see citing works
Rodriguez, A. L., Nong, Y., Sekaran, N. K., Alagille, D., Tamagnan, G. D., & Conn, P. J. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.016139 · Cited by 123 · see citing works
Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation
Kato, R., Nonami, A., Taketomi, T., Wakioka, T., Kuroiwa, A., Matsuda, Y., & Yoshimura, A. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00259-6 · Cited by 118 · see citing works
AMPA Receptors in the Therapeutic Management of Depression
Bleakman, D., Alt, A. J., & Witkin, J. M. (2007) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152707780363258 · Cited by 114 · see citing works
Fujimaki, K. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00084-6 · Cited by 110 · see citing works
Getting a first clue about SPRED functions
Bundschu, K., Walter, U., & Schuh, K. (2007) · BioEssays · doi:10.1002/bies.20632 · Cited by 97 · see citing works
Bachis, A., Mallei, A., Cruz, M. I., Wellstein, A., & Mocchetti, I. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.014 · Cited by 96 · see citing works
Spred1Is Required for Synaptic Plasticity and Hippocampus-Dependent Learning
Denayer, E., Ahmed, T., Brems, H., van Woerden, G. M., Borgesius, N. Z., Callaerts‐Vegh, Z., Yoshimura, A., Hartmann, D., Elgersma, Y., D’Hooge, R., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4698-08.2008 · Cited by 96 · see citing works
AMPA Receptor Potentiators: Application for Depression and Parkinsons Disease
O'Neill, M., & Witkin, J. M. (2007) · Current Drug Targets · doi:10.2174/138945007780618517 · Cited by 94 · see citing works
S-Adenosylmethionine: molecular, biological, and clinical aspects—an introduction,,
Lieber, C. S., & Packer, L. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.5.1148s · Cited by 90 · see citing works
Hughes, Z. A., Liu, F., Platt, B. J., Dwyer, J. M., Pulicicchio, C. M., Zhang, G., Schechter, L. E., Rosenzweig-Lipson, S., & Day, M. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.03.004 · Cited by 88 · cited 1× · see citing works
“Although the effects of estrogen levels during the course of depression in males remains uncertain, data indicate that gonadectomy-related changes in mood within this population can be alleviated by estrogen treatments (Hughes et al., 2008).”
BackgroundERα, but not ERβ, mediates the expression of sexual behavior in the female rat
Mazzucco, C., Walker, H. A., Pawluski, J. L., Lieblich, S. E., & Galea, L. A. M. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.03.016 · Cited by 85 · see citing works
Kott, S., Werner, M., Körber, C., & Hollmann, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4185-06.2007 · Cited by 82 · see citing works
Variation in brain-derived neurotrophic factor (BDNF) gene is associated with symptoms of depression
Duncan, L. E., Hutchison, K. E., Carey, G., & Craighead, W. E. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.08.016 · Cited by 81 · see citing works
S-Adenosylmethionine: molecular, biological, and clinical aspects—an introduction,,
Lieber, C. S., & Packer, L. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76/5.1148s · Cited by 79 · see citing works
Bacchi, F., Mathé, A. A., Jiménez, P., Stasi, L. P., Arban, R., Gerrard, P. A., & Caberlotto, L. (2006) · Peptides · doi:10.1016/j.peptides.2006.07.020 · Cited by 79 · see citing works
Effect of sildenafil on anxiety in the plus-maze test in mice.
Kurt, M., Bilge, S. S., Aksöz, E., et al. (2004) · PubMed · Cited by 78 · see citing works
Melanin-Concentrating Hormone MCH1 Receptor Antagonists
Shimazaki, T., Yoshimizu, T., & Chaki, S. (2006) · CNS Drugs · doi:10.2165/00023210-200620100-00002 · Cited by 73 · see citing works
The principle of complementarity: chemical versus biological space
Haggarty, S. J. (2005) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2005.04.006 · Cited by 72 · see citing works
Stargazin controls the pharmacology of AMPA receptor potentiators
Tomita, S., Sekiguchi, M., Wada, K., Nicoll, R. A., & Bredt, D. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603128103 · Cited by 70 · see citing works
Bespalov, A., van Gaalen, M. M., Sukhotina, I. A., Wicke, K. M., Mezler, M., Schoemaker, H., & Groß, G. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.06.089 · Cited by 68 · see citing works
Behavioral profiling of NPY in aggression and neuropsychiatric diseases
Karl, T., & Herzog, H. (2006) · Peptides · doi:10.1016/j.peptides.2006.07.027 · Cited by 68 · see citing works
Caberlotto, L. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00231-1 · Cited by 67 · see citing works
Ishida, H., Shirayama, Y., Iwata, M., Katayama, S., Yamamoto, A., Kawahara, R., & Nakagome, K. (2007) · Hippocampus · doi:10.1002/hipo.20264 · Cited by 67 · see citing works
Assembly and cell surface expression of KA‐2 subunit‐containing kainate receptors
Gallyas, F., Ball, S. M., & Molnár, E. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01945.x · Cited by 64 · see citing works
Bolaños, C. A., Perrotti, L. I., Edwards, S., Eisch, A. J., Barrot, M., Olson, V. G., Russell, D. S., Neve, R. L., & Nestler, E. J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-20-07569.2003 · Cited by 62 · see citing works
Tsai, S., Hong, C., Liou, Y., Yu, Y. W. ‐., & Chen, T. (2008) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e328308bbc0 · Cited by 60 · see citing works
Galea, L. A. M., Lee, T. T.-Y., Kostaras, X., et al. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00849-1 · Cited by 57 · see citing works
Targeting Neurotrophic/Growth Factor Expression and Signaling for Antidepressant Drug Development
Tanis, K. Q., Newton, S. S., & Duman, R. S. (2007) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152707780363276 · Cited by 57 · see citing works
Öngür, D., Pohlman, J., Dow, A. L., Eisch, A. J., Edwin, F., Heckers, S., Cohen, B. M., Patel, T. B., & Carlezon, W. A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.11.014 · Cited by 56 · see citing works
Hebb, A. L. O., Robertson, H. A., & Denovan‐Wright, E. M. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.08.002 · Cited by 56 · see citing works
Tsai, S. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.09.043 · Cited by 55 · see citing works
Preventing Recurrent Depression
Blier, P., Keller, M. B., Pollack, M. H., Thase, M. E., Zajecka, J., & Dünner, D. L. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.0307e06 · Cited by 53 · see citing works
Metabotropic glutamate 2/3 receptors as drug targets
Marek, G. J. (2003) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2003.10.003 · Cited by 52 · see citing works
Körber, C., Werner, M., Kott, S., Ma‐Högemeier, Z., & Hollmann, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0424-07.2007 · Cited by 51 · see citing works
Major depression: emerging therapeutics
Sen, S., & Sanacora, G. (2008) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20043 · Cited by 48 · see citing works
Stargazin involvement with bipolar disorder and response to lithium treatment
Silberberg, G., Levit, A., Collier, D. A., Clair, D. S., Munro, J., Kerwin, R. W., Tondo, L., Floris, G., Breen, G. D., & Navon, R. (2008) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e3282f974ca · Cited by 48 · see citing works
Wise, D. D., Felker, A., & Stahl, S. M. (2008) · CNS Spectrums · doi:10.1017/s1092852900013742 · Cited by 44 · see citing works
Patisaul, H. B., Burke, K. T., Hinkle, R. E., Adewale, H. B., & Shea, D. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2008.11.004 · Cited by 38 · see citing works
Stargazin modulates AMPA receptor antagonism
Cokić, B., & Stein, V. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.02.012 · Cited by 36 · see citing works
Dwivedi, Y., Rizavi, H. S., Teppen, T. L., Zhang, H., Mondal, A. C., Roberts, R. C., Conley, R. R., & Pandey, G. N. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301641 · Cited by 35 · see citing works
The Three Faces of the Antidepressants:
Healy, D. (1999) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199903000-00007 · Cited by 33 · see citing works
Tsai, S., Hong, C., Liou, Y., Chen, T., Chen, M., Hou, S.-J., Yen, F.-C., & Yu, Y. W. ‐. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.06.028 · Cited by 29 · see citing works
Epigenetic inactivation of the ERK inhibitor Spry2 in B-cell diffuse lymphomas
Sánchez, A., Setién, F., Martinez, N., et al. (2008) · Oncogene · doi:10.1038/onc.2008.129 · Cited by 28 · see citing works
Anxiolytic-like effects through a GLUK5 kainate receptor mechanism
Alt, A. J., Weiss, B., Ornstein, P. L., Gleason, S. D., Bleakman, D., Stratford, R. E., & Witkin, J. M. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.02.005 · Cited by 26 · see citing works
Gerrits, M., Bakker, P. L., Koch, T., & Horst, G. J. T. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04701.x · Cited by 24 · see citing works
Hou, S.-J., Yen, F.-C., & Tsai, S. (2008) · Medical Hypotheses · doi:10.1016/j.mehy.2008.09.009 · Cited by 20 · see citing works
Pharmacogenetics of Major Depression
Lekman, M., Paddock, S., & McMahon, F. J. (2008) · Molecular Diagnosis & Therapy · doi:10.1007/bf03256297 · Cited by 19 · see citing works
Are Depressed Outpatients With and Without a Family History of Substance Use Disorder Different?
Davis, L. L., & Frazier, E. C. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n1214 · Cited by 15 · see citing works
ERβ protein expression in female cynomolgus monkey and CF-1 mouse brain: Western analysis
Hu, S., Lu, S., Kaplan, J. R., Adams, M. R., & Simon, N. G. (2005) · Journal of Neurobiology · doi:10.1002/neu.20139 · Cited by 7 · see citing works
Trilostane exerts antidepressive effects among wild-type, but not estrogen receptor β knockout mice
Koonce, C. J., Walf, A. A., & Frye, C. A. (2009) · Neuroreport · doi:10.1097/wnr.0b013e32832e0c44 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Semkovska, M., & McLoughlin, D. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.009 · Cited by 718 · see citing works
Baldessarini, R. J. (2013) · doi:10.1007/978-1-4614-3710-9 · Cited by 365 · see citing works
A Role for Repressive Histone Methylation in Cocaine-Induced Vulnerability to Stress
Covington, H. E., Maze, I., Sun, H., Bomze, H. M., DeMaio, K. D., Wu, E. Y., Dietz, D. M., Lobo, M. K., Ghose, S., Mouzon, E., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.007 · Cited by 289 · see citing works
Self-citationEmerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression
Francis, T. C., & Lobo, M. K. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.09.007 · Cited by 230 · see citing works
Andrus, B. M., Blizinsky, K., Vedell, P. T., Dennis, K., Shukla, P. K., Schaffer, D. J., Radulovic, J., Churchill, G. A., & Redei, E. E. (2012) · Molecular Psychiatry · doi:10.1038/mp.2010.119 · Cited by 178 · see citing works
SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens
Kim, H.-D., Hesterman, J., Call, T., Magazu, S., Keeley, E., Armenta, K., Kronman, H., Neve, R. L., Nestler, E. J., & Ferguson, D. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0212-16.2016 · Cited by 158 · see citing works
Self-citationKoike, H., Iijima, M., & Chaki, S. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.034 · Cited by 114 · see citing works
Lindemann, L., Porter, R. H., Scharf, S. H., Kuennecke, B., Bruns, A., von Kienlin, M., Harrison, A. C., Paehler, A., Funk, C., Gloge, A., et al. (2015) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.222463 · Cited by 107 · see citing works
Antidepressant effects of TNF-α blockade in an animal model of depression
Krügel, U., Fischer, J., Radicke, S., Sack, U., & Himmerich, H. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.01.007 · Cited by 104 · see citing works
The Relationship between DNA Methylation and Antidepressant Medications: A Systematic Review
Webb, L. M., Phillips, K. E., Ho, M. C., Veldic, M., & Blacker, C. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030826 · Cited by 84 · see citing works
Lewis, A. S., & Picciotto, M. R. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3126-5 · Cited by 38 · see citing works
Vakhitova, Y. V., Kalinina, T. S., Zainullina, L. F., Lusta, A. Y., Volkova, A. V., Kudryashov, N. V., Gudasheva, T. A., Shimshirt, A. A., Kadnikov, I. A., Voronin, M. V., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413381 · Cited by 21 · see citing works
Réus, G. Z., Stringari, R. B., Rezin, G. T., Fraga, D. B., Daufenbach, J. F., Scaini, G., Benedet, J., Rochi, N., Streck, E. L., & Quevedo, J. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-011-0718-2 · Cited by 23 · see citing works
- Authors
- Covington, H. E., Vialou, V., & Nestler, E. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Nestler, Eric J.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 58
- Issue
- 4-5
- Pages
- 683-693
- ISSN
- 0028-3908 (ISSN-L)
- PMC
- PMC2821954
- OpenAlex
- W2081351662
- Cited by
- 98
- References
- 162
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 9 · 2015: 9 · 2014: 4 · 2013: 12 · 2012: 10
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- depression, antidepressant targets, neurotrophic factors, glutamate receptors, nuclear receptors, epigenetic mechanisms, synaptic signaling
- MeSH terms
- Animals, Antidepressive Agents, Cell Nucleus, Depressive Disorder, Humans, Synapses, Drug Design, Drug Delivery Systems
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
