Cited by 452Gut microbiota and healthAnimal Nutrition and PhysiologyPolyamine Metabolism and Applications

The DOI matches its Crossref record; 273 of the 274 references it cites were found in a registry or an index.

Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences

Blachier, F., Mariotti, F., Huneau, J. F., Tomé, D.·2007·Amino Acids

Open this paper in CoChat — free account

Abstract

Depending on the amount of alimentary proteins, between 6 and 18 g nitrogenous material per day enter the large intestine lumen through the ileocaecal junction. This material is used as substrates by the flora resulting eventually in the presence of a complex mixture of metabolites including ammonia, hydrogen sulfide, short and branched-chain fatty acids, amines; phenolic, indolic and N-nitroso compounds. The beneficial versus deleterious effects of these compounds on the colonic epithelium depend on parameters such as their luminal concentrations, the duration of the colonic stasis, the detoxication capacity of epithelial cells in response to increase of metabolite concentrations, the cellular metabolic utilization of these metabolites as well as their effects on colonocyte intermediary and oxidative metabolism. Furthermore, the effects of metabolites on electrolyte movements through the colonic epithelium must as well be taken into consideration for such an evaluation. The situation is further complicated by the fact that other non-nitrogenous compounds are believed to interfere with these various phenomenons. Finally, the pathological consequences of the presence of excessive concentrations of these compounds are related to the short- and, most important, long-term effects of these compounds on the rapid colonic epithelium renewing and homeostasis.

Integrity signals

Registry

Crossref · 10.1007/s00726-006-0477-9

Cites

273 of 273 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513
Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and Finland
Lichtenstein, P., Holm, N. V., Verkasalo, P. K., Iliadou, A., Kaprio, J., Koskenvuo, M., Pukkala, E., Skytthe, A., & Hemminki, K. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007133430201 · Cited by 4,114
Polyamine metabolism and function
Pegg, A. E., & McCann, P. P. (1982) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1982.243.5.c212 · Cited by 1,661
Utilization of Nutrients by Isolated Epithelial Cells of the Rat Colon
Roediger, W. E. W. (1982) · Gastroenterology · doi:10.1016/s0016-5085(82)80339-9 · Cited by 1,187
Toxicology Of Hydrogen Sulfide
Reiffenstein, R. J., Hulbert, W. C., & Roth, S. (1992) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.32.040192.000545 · Cited by 971
Balancing Life-Style and Genomics Research for Disease Prevention
Willett, W. C. (2002) · Science · doi:10.1126/science.1071055 · Cited by 888
Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications
Thomas, T., & Thomas, T. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000852 · Cited by 862
The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
Ricquier, D., & Bouillaud, F. (2000) · Biochemical Journal · doi:10.1042/bj3450161 · Cited by 811
Effects of short chain fatty acids on gut morphology and function
Scheppach, W. (1994) · Gut · doi:10.1136/gut.35.1_suppl.s35 · Cited by 756
THE COLONIC EPITHELIUM IN ULCERATIVE COLITIS: AN ENERGY-DEFICIENCY DISEASE?
Roediger, W. E. W. (1980) · The Lancet · doi:10.1016/s0140-6736(80)91934-0 · Cited by 728

Show all 274 references

Research works printed but not linked: 35

SK Clinton, 1988, Cancer Res, 48, 3035
JD Cremin, 2003, Am J Physiol, 285, G105
AJ Cross, 2003, Cancer Res, 63, 2358
B Darcy-Vrillon, 1993, J Nutr, 123, 234
B Duranton, 1997, Cancer Res, 57, 573
P Evenepoel, 1999, Am J Physiol, 277, G935
J Fioramonti, 1994, Am J Physiol, 267, G960
DD Ginty, 1989, Am J Physiol, 257, G145
E Giovanucci, 1994, Cancer Res, 54, 2930
RA Goldhom, 1994, Cancer Res, 54, 718
ME Handlogten, 2005, Am J Physiol, 288, G1036
BG Heerdt, 1994, Cancer Res, 54, 3288
CM Hogaboam, 1995, Am J Physiol, 268, G673
R Hughes, 2000, Curr Issues Intest Microbiol, 1, 51
H Inoue, 2005, Am J Physiol, 289, F451
J Jorgensen, 2001b, Am J Physiol, 281, G405
P Kubes, 1992, Am J Physiol, 262, G1138
P Kubes, 1993, Am J Physiol, 264, G143
L Lee, 1981, Cancer Res, 41, 3992
JL Lyon, 1987, J Natl Cancer Inst, 78, 853
GT Macfarlane, 1986, J Gen Microbiol, 132, 1647
GT Macfarlane, 1992, J Appl Bacteriol, 72, 57
S Mc Cormack, 1991, Am J Physiol, 260, G795
B Mouillé, 2004, Am J Physiol, 287, G344
MW Musch, 2001, Am J Physiol, 280, G687
M Niiyama, 1979, Am J Vet Res, 40, 716
I Noordgaard, 1995, Nutrition, 11, 129
DL Osborne, 1990, Am J Physiol, 21, G576
BC Radcliffe, 1987, Am J Physiol, 253, G246
T Sobko, 2004, Am J Physiol, 287, G993
F Suarez, 1998, Am J Physiol, 274, G727
S Ugawa, 2001, Am J Physiol, 281, G365
T Witthöf, 1998, Am J Physiol, 275, G564
O Wrong, 1965, Clin Sci, 28, 357
A Zimber, 1972, Am J Clin Nutr, 223, 1004

Sorted by citations

Items 301–400 of 450

Microbiota, mitochondria, and epigenetics in health and disease: converging pathways to solve the puzzle
Mikusic, N. L. R., Prince, P. D., Choi, M. R., Chuffa, L. G. D. A., Simão, V. A., Castro, C., Manucha, W. A., & Quesada, I. (2025) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-025-03072-w · Cited by 11
Intake of a Chicken Protein‐Based or Soy Protein‐Based Diet Differentially Affects Growth Performance, Absorptive Capacity, and Gut Microbiota in Young Rats
Zhao, F., Wang, C., Song, S., Fang, C., Kristiansen, K., & Li, C. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202101124 · Cited by 11
Standardisation of the C:N ratio in ileal digesta changes relationships among fermentation end-products during in vitro hindgut fermentation in pigs
Lammers-Jannink, K., Pellikaan, W. F., de Vries, S., Stigter, E. C. A., & Gerrits, W. J. J. (2023) · animal · doi:10.1016/j.animal.2023.101026 · Cited by 8
Gut microbiota from end-stage renal disease patients disrupt gut barrier function by excessive production of phenol
Wang, X., Hao, Y., Liu, X., Yu, S., Zhang, W., Yang, S., Yu, Z., & Ren, F. (2019) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2019.03.015 · Cited by 8
Amino Acids as Neurotransmitters. The Balance between Excitation and Inhibition as a Background for Future Clinical Applications
Nartsissov, Y. R. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.103760 · Cited by 8
Free Amino Acid–Enriched Diets Containing Rapidly but Not Slowly Digested Carbohydrate Promote Amino Acid Absorption from Intestine and Net Fluxes across Skeletal Muscle of Pigs
Zhou, J., Tu, J., Wang, L., Yang, L., Yang, G., Zhao, S., Zeng, X., & Qiao, S. (2022) · Journal of Nutrition · doi:10.1093/jn/nxac165 · Cited by 7
Effects of alimentary-derived bacterial metabolites on energy metabolism in colonic epithelial cells and inflammatory bowel diseases
Andriamihaja, M., & Blachier, F. (2024) · Exploration of Medicine · doi:10.37349/emed.2024.00220 · Cited by 7
Self-citation
Unveiling the microbiota-mediated impact of different dietary proteins on post-digestive processes: A simulated in vitro approach
Ma, X., Fan, M., Hannachi, K., Qian, H., Li, Y., & Li, Y. (2024) · Food Research International · doi:10.1016/j.foodres.2024.115381 · Cited by 9
Impact of organic biomass waste composition on anaerobic acid fermentation
Lu, C. D., Lin, Y., & Hwu, F.-Y. (2025) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2025.108004 · Cited by 7
Yogurt and health: a focus on its matrix
Tremblay, A., Drouin‐Chartier, J., Marette, A., & Drapeau, V. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2524472 · Cited by 9
Effects of continuously infusing glucose or casein into the terminal ileum on biomarkers of metabolism, inflammation, and intestinal morphology in growing pigs
Mayorga, E. J., Horst, E. A., Al‐Qaisi, M., Goetz, B. M., Abeyta, M. A., Rodríguez-Jiménez, S., Lei, S., Acosta, J. A., Patience, J. F., Serao, M. C. R., et al. (2021) · Journal of Animal Science · doi:10.1093/jas/skab163 · Cited by 7
Assessment of the Effects of Edible Microalgae in a Canine Gut Model
Delsante, C., Pinna, C., Sportelli, F., Dalmonte, T., Stefanelli, C., Vecchiato, C. G., & Biagi, G. (2022) · Animals · doi:10.3390/ani12162100 · Cited by 12
Pet food: quality and quality improvement
Cipollini, I. (2008) · AMS Dottorato Institutional Doctoral Theses Repository (University of Bologna) · doi:10.6092/unibo/amsdottorato/1058 · Cited by 7
Effects of dietary supplementation with increasing doses of lactose on faecal bacterial populations and metabolites and apparent total tract digestibility in adult dogs
Grandi, M., Pinna, C., Bonaldo, A., Stefanelli, C., Vecchiato, C. G., Zaghini, G., & Biagi, G. (2018) · Italian Journal of Animal Science · doi:10.1080/1828051x.2018.1459210 · Cited by 7
Developmental Amino Acid Metabolism in the Pig Small and Large Intestine Epithelial Cells
Blachier, F., Wu, G., Yin, Y., Hou, Y., & Andriamihaja, M. (2013) · Springer eBooks · doi:10.1007/978-3-7091-1328-8_5 · Cited by 7
Self-citation
Digestion kinetics of protein feed ingredients and their impact on nitrogen utilization in growing pigs
Li, J., Cao, Y., Yu, X., Huang, J., Jiang, R., Huang, M., Zhao, J., Han, D., & Wang, J. (2025) · Animal nutrition · doi:10.1016/j.aninu.2024.12.006 · Cited by 6
The gut as a central hub for multi-organ crosstalk in aging
Zhang, X., Li, R., Gao, Y., Zhang, W., Ni, T., & Liu, Y. (2026) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-026-06129-w · Cited by 7
Hydrolysis of pea protein differentially modulates its effect on iron bioaccessibility, sulfur availability, composition and activity of gut microbial communities in vitro
Zhang, Y. Y., Stockmann, R., Ng, K., & Ajlouni, S. (2023) · Food & Function · doi:10.1039/d3fo00504f · Cited by 7
Effects of Diets Based on Hydrolyzed Chicken Liver and Different Protein Concentrations on the Formation and Deamination of Biogenic Amines and Total Antioxidant Capacity of Dogs
Pinto, C. F. D., Monteiro, C. F. C., Bortolo, M., Marx, F. R., Model, J. F. A., Vinagre, A. S., & Trevizan, L. (2023) · Animals · doi:10.3390/ani13162578 · Cited by 6
Transcriptomics yields valuable information regarding the response mechanisms of Chinese Min pigs infected with PEDV
Li, H., Zhou, C., Zhang, M., Yuan, N., Huang, X., Xiang, J., Wang, L., & Shi, L. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2023.1295723 · Cited by 6
Microbiota and beneficial metabolites in colorectal cancer
González, A., Fullaondo, A., Odriozola, I., & Odriozola, A. (2024) · Advances in genetics · doi:10.1016/bs.adgen.2024.08.002 · Cited by 6
Xenobiotic metabolism activity of gut microbiota from six marine species: Combined taxonomic, metagenomic, and in vitro transformation analysis
Zhang, S., Hou, R., Wang, Y.-C., Huang, Q.-Y., Lin, L., Li, H., Liu, S., Jiang, Z., Huang, X., & Xu, X. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.136152 · Cited by 8
Fructooligosaccharide decreases the production of uremic toxin precursor through modulating gut microbes mediated tyrosine metabolism pathway
Lu, J., Li, J., Yin, J.-T., Li, C., Zhang, S., Guo, J., & Duan, J. (2021) · Future Foods · doi:10.1016/j.fufo.2021.100069 · Cited by 7
Digging deep for nutrients and metabolites derived from high dietary protein intake and their potential functions in metabolic health
Gilsenan, S., Leong, D., Cotter, P. D., Brennan, L., & Nilaweera, K. N. (2024) · Nutrition Research Reviews · doi:10.1017/s0954422424000374 · Cited by 5
Effects of crude protein and lactose levels in diets on growth performance, intestinal morphology, and expression of genes related to intestinal integrity and immune system in weaned piglets
Soares, M. H., Rodrigues, G. A., Barbosa, L. M. D. R., Júnior, D. T. V., Santos, F. C., Rocha, G. C., Campos, P. H. R. F., & Saraiva, A. (2020) · Animal Science Journal · doi:10.1111/asj.13429 · Cited by 6
Dietary Protein and Colonic Microbiota
Boudry, G., Le Huërou-Luron, I., & Michel, C. (2016) · The Molecular Nutrition of Amino Acids and Proteins · doi:10.1016/b978-0-12-802167-5.00015-3 · Cited by 5
Association between exercise and changes in gut microbiota profile: a review
Khaledi, M., Darvishi, M., Sameni, F., Shahrjerdi, S., Karami, E., Barahui, N., Hemmati, J., Hasheminasab, M. S., Sanae, M.-J., Akhavan‐Sigari, R., et al. (2023) · Sport Sciences for Health · doi:10.1007/s11332-023-01132-1 · Cited by 5
High-protein diets increase microbiota associated p-cresol production in the colon and reduce gut barrier function in a sex-dependent manner
James, D., Batool, M., Poveda, C. G., Hayirli, Z., Callow, C., Abbas, M., Linden, B., Gibson, J., Griffin, B. A., Elmore, J. S., et al. (2026) · European Journal of Nutrition · doi:10.1007/s00394-025-03885-6 · Cited by 6
Unveiling the impact of colonic pH and pH-sensing receptors in blood pressure regulation
Dinakis, E., Xie, L., Vecchio, E. A., Mackay, C. R., & Marques, F. Z. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2656346 · Cited by 5
Relevance of Indian Traditional Herbal Brews for Gut Microbiota Balance
Joshi, D. D., Deb, L., Kaul, K., Somkuwar, B. G., Rana, V. S., & Singh, R. (2024) · Indian Journal of Microbiology · doi:10.1007/s12088-024-01251-4 · Cited by 5
Effects of silymarin supplementation in late pregnancy and lactation on reproductive performance, colostrum quality, blood biochemistry and inflammation levels of sows
Cong, G., Xia, S., Liu, C., Li, J., Hung, I., Zhang, L., Guo, S., & Zhao, B. (2025) · Tropical Animal Health and Production · doi:10.1007/s11250-025-04320-y · Cited by 5
In vitro fermentation of Cucumis sativus fructus extract by canine gut microbiota in combination with two probiotic strains
Belà, B., Coman, M. M., Verdenelli, M. C., Bianchi, C., Pignataro, G., Fiorini, D., & Silvi, S. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103585 · Cited by 5
Dietary supplementation with citrus extract alters the plasma parameters, circulating amino acid profiles and gene expression of small intestinal nutrient transporters in Chinese yellow‐feathered broilers
Yu, M., Li, Z., Wang, G., Cui, Y., Rong, T. Z., Tian, Z., Liu, Z., Li, J., Chen, W., & Ma, X. (2020) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10525 · Cited by 5
Crude protein and lactose effects on performance, intestinal and immune function of piglets fed diets without antimicrobials growth promoters
Júnior, D. T. V., Rodrigues, G. D. A., Soares, M. H., Rocha, G. C., Campos, P. H. R. F., & Saraiva, A. (2021) · Livestock Science · doi:10.1016/j.livsci.2021.104566 · Cited by 5
The potential impact of the ketogenic diet on gut microbiota in the context of neurological disorders
Gudan, A., & Stachowska, E. (2022) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.2478/ahem-2022-0019 · Cited by 5
Short-Term Partial Replacement of Corn and Soybean Meal with High-Fiber or High-Protein Feedstuffs during Metabolizable Energy Assay Influenced Intestinal Histomorphology, Cecal Short-Chain Fatty Acids, and Selected Nutrient Transporters in 21-Day-Old Broiler Chickens
Olukosi, O. A., Oluseyifunmi, I. W., Yang, L., & Zedonek, S. S. (2022) · Animals · doi:10.3390/ani12172193 · Cited by 5
Microbiota and detrimental protein derived metabolites in colorectal cancer
González, A., Odriozola, I., Fullaondo, A., & Odriozola, A. (2024) · Advances in genetics · doi:10.1016/bs.adgen.2024.06.001 · Cited by 7
Factors affecting plant food particle behaviour during in vitro colonic microbial fermentation
Yao, H. L., Flanagan, B. M., Williams, B. A., Mikkelsen, D., & Gidley, M. J. (2024) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2024.104802 · Cited by 5
The impact of lower gut nitrogen supply on nitrogen balance and urea kinetics in growing pigs fed a valine-limiting diet1
Columbus, D. A., Lapierre, H., Fuller, M. F., Htoo, J. K., & de Lange, C. F. M. (2012) · Journal of Animal Science · doi:10.2527/jas.51843 · Cited by 5
Dietary protein sources and their effects on faecal odour and the composition of volatile organic compounds in faeces of French Bulldogs
Urrego, M. I. G., Pedreira, R. S., Santos, K. D. M., Ernandes, M. C., Santos, J. P. F., Vendramini, T. H. A., Eberlin, M. N., Balieiro, J. C. D. C., Pontieri, C. F. F., & Brunetto, M. A. (2021) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13605 · Cited by 5
[Case report. Phenprocoumon (Marcumar, Falithrom) as an unusual reason for coumarin poisoning in a dog].
Lutze, G., Römhild, W., Elwert, J., Leppelt, J., & Kutschmann, K. (2003) · PubMed · Cited by 5
Effect of Different Coffee Brews on Tryptophan Metabolite-Induced Cytotoxicity in HT-29 Human Colon Cancer Cells
Castaldo, L., Toriello, M., Izzo, L., Sessa, R., Lombardi, S., Trombetti, S., Rodríguez-Carrasco, Y., Ritieni, A., & Grosso, M. (2022) · Antioxidants · doi:10.3390/antiox11122458 · Cited by 7
Dexi disruption depletes gut microbial metabolites and accelerates autoimmune diabetesPreprint
Davison, L., Wallace, M. D., Preece, C., Hughes, K., Todd, J. A., Davies, B., & Callaghan, C. O. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/393421 · Cited by 5
Sensing the impact of diet composition on protein fermentation by direct electrochemical NH4+ sensing in gastrointestinal digesta
Leonardi, F., Sijabat, R. R., Minderhoud, R., Even, A. J. G., Mathwig, K., Armstrong, R. E., de Vries, S., Goris, A. H. C., & Hoof, C. A. V. (2023) · Biosensors and Bioelectronics X · doi:10.1016/j.biosx.2023.100406 · Cited by 4
Multiomics Analysis Reveals Leucine Deprivation Promotes Bile Acid Synthesis by Upregulating Hepatic CYP7A1 and Intestinal Turicibacter sanguinis in Mice
Niu, Y., Yu, H., Yan, Z.-H., & Yan, X. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2024.04.033 · Cited by 4
Effects of hydrolyzed chicken liver on digestibility, fecal and urinary characteristics, and fecal metabolites of adult dogs
Pinto, C. F. D., Sezerotto, P. P., Barcellos, J. F., Bortolo, M., Guldenpfennig, R., Marx, F. R., & Trevizan, L. (2023) · Journal of Animal Science · doi:10.1093/jas/skad366 · Cited by 4
Growth Performance, Biochemical Blood Indices, and Large Intestine Physiology of Rats Fed Diets with Alfalfa Protein-Xanthophyll Concentrate
Barszcz, M., Tuśnio, A., Bachanek, I., Gawin, K., Skomiał, J., & Taciak, M. (2021) · Animals · doi:10.3390/ani11072069 · Cited by 5
Functional short-chain carbohydrates (prebiotics) in the diet to improve the microbiome and health of the gastrointestinal tract
Muir, J. G., Yao, C. K., & Gibson, P. G. (2015) · Animal Production Science · doi:10.1071/an15277 · Cited by 4
Long‐term effect of early antibiotic exposure on amino acid profiles and gene expression of transporters and receptors in the small intestinal mucosa of growing pigs with different dietary protein levels
Yu, M., Mu, C., Zhang, C., Yang, Y., Su, Y., & Zhu, W. (2019) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10028 · Cited by 4
Gut-brain axis and immunoneuroendocrine modulation in neurological and psychiatric disorders: A systematic review
Lami, K. F., de Oliveira, V. F., & Batista, K. Z. S. (2021) · Research Society and Development · doi:10.33448/rsd-v10i4.14185 · Cited by 4
Feed Additives in Swine Diets
O’Shea, C. J. (2022) · doi:10.1002/9781119583998.ch18 · Cited by 4
The Human Microbiome—A Physiologic Perspective
Yang, X. J., Louwies, T., Mars, R. A. T., & Kashyap, P. (2024) · Comprehensive physiology · doi:10.1002/cphy.c230013 · Cited by 14
Amino acid metabolism-mediated immune cell fate and function in pigs
He, L., Jin, S., Li, Y., & Yin, Y. (2025) · Animal Nutriomics · doi:10.1017/anr.2025.5 · Cited by 3
Enabling rational gut microbiome manipulations by understanding gut ecology through experimentally-evidenced in silico models
Ortiz, J. P. M., McClure, D. D., Shanahan, E. R., Dehghani, F., Holmes, A. J., & Read, M. N. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1965698 · Cited by 4
Nutritional Values and In Vitro Fermentation Characteristics of 29 Different Chinese Herbs
Xiao, L., Yi, S., Azad, M. A. K., Huang, M., Guo, X., & Kong, X. (2022) · Agriculture · doi:10.3390/agriculture12091285 · Cited by 3
Metabolism of Dietary Substrates by Intestinal Bacteria and Consequences for the Host Intestine
Blachier, F. (2023) · Springer eBooks · doi:10.1007/978-3-031-26322-4_3 · Cited by 4
Self-citation
Dietary fibre fractions supplementation modulates pro-inflammatory cytokines, hindgut fermentation metabolites, and fecal consistency score in nursery pigs
Erinle, T. J., Babatunde, O. O., Htoo, J. K. K., Mendoza, S. M., & Columbus, D. A. (2024) · Canadian Journal of Animal Science · doi:10.1139/cjas-2024-0123 · Cited by 3
Usefulness of Probiotics for Neonates?
Butel, M., Waligora‐Dupriet, A., & Aires, J. (2012) · InTech eBooks · doi:10.5772/51265 · Cited by 3
Investigation of the cytotoxicity of apidaecin on intestinal epithelial cells of tilapia (Oreochromis niloticus) in vitro
Zhou, X., Wang, Y., Pan, Y.-J., & Li, W. (2008) · Aquaculture International · doi:10.1007/s10499-008-9170-1 · Cited by 3
Temporal changes in gut microbiota and signaling molecules of the gut–brain axis in mice fed meat protein dietsPreprint
Xie, Y., Zhou, G., Wang, C., Xu, X., & Li, C. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/329953 · Cited by 3
Gut Microbiota and Related Metabolites in Children With Egg White Sensitization
Chen, C., Yeh, Y., Chen, K.-J., Chang, H.-J., Cheng, M., Lo, C.-J., & Lai, H. (2024) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000004628 · Cited by 2
Effects of dietary inclusion of hydrolysed feather meal on faecal fermentation products in adult female dogs
Chiofalo, B., Armone, R., Randazzo, A., Nava, V., Barbato, M., & Stefanon, B. (2025) · Italian Journal of Animal Science · doi:10.1080/1828051x.2025.2576519 · Cited by 2
The Role of CP Level and Interaction with Antibiotics in the Post-Weaning Piglets’ Diet: Growth Performance, Body Composition, Nutrient Digestion, and Intestinal Health
Wang, R., Hou, L., Wu, Q., Wen, X., Xiong, Y., Yang, X., Gao, K., Jiang, Z., Cao, S., & Wang, L. (2025) · Animals · doi:10.3390/ani16010024 · Cited by 2
Fate of dietary phytochemicals in human gut and interaction with intestinal flora
Du, B., Ma, Z., Xin, G., Yang, Y., & Xu, B. (2022) · Journal of Food Bioactives · doi:10.31665/jfb.2022.18307 · Cited by 2
Revealing the hidden heights of microbial metabolites on reproductive physiology
Jayamurali, D., Saminathan, G., Varier, K. M., Acharya, P. S., Manoharan, N., Parasuraman, R., Gajendran, B., & Govindarajulu, S. N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90113-0.00004-3 · Cited by 2
Development and validation of a systematic platform for broad-scale profiling of microbial metabolites
Wang, X.-N., Yin, Y., Cheng, X. S., Chen, L., Chen, M., Zheng, J., Jin, Y., Liu, J., Liu, L., & Xin, G.-Z. (2019) · Talanta · doi:10.1016/j.talanta.2019.03.087 · Cited by 2
Metabolism of alimentary compounds by the intestinal microbiota and consequences for gut health
Blachier, F., & Kong, X. (2023) · Journal of Food Nutrition and Diet Science · doi:10.55976/fnds.1202311533-19 · Cited by 2
Self-citation
Effect of Lycopus lucidus Turcz. supplementation on gut microflora and short chain fatty acid composition in Crj: CD-1 mice
Na, E., & Lim, S. (2022) · Biocell · doi:10.32604/biocell.2022.019807 · Cited by 2
Animal fibre : a key factor for gastrointestinal health in an obligate carnivore: the cheetah
Depauw, S. (2012) · Ghent University Academic Bibliography (Ghent University) · Cited by 2
Effects of heat stress on intestinal physiology and immunometabolism
Mayorga, E. J. (2022) · doi:10.31274/td-20240329-264 · Cited by 2
Composition of linear and branched short-chain fatty acids in human milk and newborn feces: influence of perinatal and maternal factors
Luna-Guzmán, C. E., Zarzoza-Mendoza, I. C., Cervantes-Monroy, E., Villa-Morales, J., Carmona-Sierra, F. V., Maldonado‐Hernández, J., Domínguez-Calderón, I., & Rodríguez‐Cruz, M. (2024) · Food & Function · doi:10.1039/d4fo03568b · Cited by 1
Supplementation of Arginine or N-Carbamylglutamate Affects Jejunum Development, Global Arginine Bioavailability Ratio, and Stress-Related Indices in Young Rex Rabbits
Qin, F., Zhang, L., Shao, L., Li, J., Yang, J., Zhai, P., & Zhang, X. (2025) · Animals · doi:10.3390/ani15101354 · Cited by 1
Hydrolyzed chicken liver and increasing crude protein levels on palatability, digestibility, and intestinal fermentation products of cats
Sezerotto, P. P., Pinto, C. F. D., da Silva, A. M., Francisco, J. C. P., Bortolo, M., Marx, F. R., Vasconcellos, R. S., & Trevizan, L. (2025) · Journal of Animal Science · doi:10.1093/jas/skaf173 · Cited by 1
Effect of oral glutamine supplementation on growth and glutamine and glucose metabolism in suckling piglets
Sciascia, Q. L., Leonardis, D. D., Görs, S., Vernunft, A., Eggert, A., Zentek, J., & Metges, C. C. (2025) · Journal of Animal Science · doi:10.1093/jas/skaf201 · Cited by 1
Source of plant proteins diverts colonic fermentation of wheat arabinoxylan
Zhao, S., Yang, Z. H., Du, J., & Chen, M. (2025) · LWT · doi:10.1016/j.lwt.2025.118664 · Cited by 1
Leptin receptor gene influences pig gut microbiota both through feed intake and independently
Suárez-Mesa, R., Laghouaouta, H., Estellé, J., Seradj, A. R., Freixedes, R. R., Pena, R. N., & Estany, J. (2025) · Animal Microbiome · doi:10.1186/s42523-025-00508-7 · Cited by 1
Effects of incrementally increased plant-based protein intake on gut microbiota and inflammatory–metabolic biomarkers in healthy adults
do Prado, S. B. R., Kamm, A., Dannenberg, K., Keidel, I., Castro‐Alves, V., Hyötyläinen, T., Lentjes, M. A. H., Repsilber, D., Marques, T. M., & Brummer, R. J. (2026) · Food & Function · doi:10.1039/d5fo02653a · Cited by 2
Effect of the Microbiota Metabolite Butyric Acid on Behavior, Neuroinflammation, and Oxidative Stress Level in a Mouse Model of Dysbiosis
Salikhzyanova, A. F., Mullakaeva, A. I., Shaidullov, I. F., Ситдикова, Г. Ф., & Yakovleva, O. V. (2025) · Neurochemical Journal · doi:10.1134/s1819712425700795 · Cited by 1
Effects of supplementary protein source, autoclaving diets, and gender on biochemical blood parameters, oxidative stress markers, and caecal fermentation in rats
Gawin, K., Tuśnio, A., Barszcz, M., Taciak, M., Święch, E., Konopka, A., Frączek, N., Szumska, M., & Pastuszewska, B. (2026) · BMC Veterinary Research · doi:10.1186/s12917-025-05266-x · Cited by 1
The impact of protein fermentation on faecal consistency and intestinal permeability in pigs
Noorman, L., Bekebrede, A. F., de Vries, S., Kies, A. K., & Gerrits, W. J. J. (2026) · animal · doi:10.1016/j.animal.2026.101815 · Cited by 1
Breed-dependent differences in gut microbiota linked to indole and skatole levels in Hezuo and DLY pigs
Gao, X., Zhang, S., & Yang, Q. (2026) · BMC Microbiology · doi:10.1186/s12866-026-05082-9 · Cited by 1
Current advances and challenges in microbiome-based mitigation of volatile organic compounds from livestock waste systems
Adnane, M., Drillich, M., & Chapwanya, A. (2026) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2026.1848842 · Cited by 1
Lower gut nitrogen supply does not affect apparent ileal digestibility of nitrogen or amino acids in growing pigs1
Columbus, D. A., Fuller, M. F., Htoo, J. K. K., & de Lange, C. F. M. (2012) · Journal of Animal Science · doi:10.2527/jas.51839 · Cited by 1
The Microbiome and Amino Acid Metabolism
Diether, N. E., & Willing, B. P. (2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839160950-00048 · Cited by 1
Co-products in maize-soybean growing-pig diets altered in vitro enzymatic insoluble fibre hydrolysis and fermentation in relation to botanical origin
Fushai, F., Tekere, M., Masafu, M. M., Akinsola, C. M., Siebrits, F. K., Nherera-Chokuda, F. V., & Kanengoni, A. T. (2019) · South African Journal of Animal Science · doi:10.4314/sajas.v49i2.1 · Cited by 1
Suplementacja wśród mężczyzn amatorsko uprawiających kulturystkę
Karpik, A., Jamioł-Milc, D., Załęska, P., & Ryterská, K. (2020) · Polski Przegląd Nauk o Zdrowiu · doi:10.20883/ppnoz.2019.60 · Cited by 1
Microbial sensing in the neonatal pig gut: effect of diet-independent and diet-dependent factors1
Wellington, M. O., Agyekum, A. K., & Kessel, A. G. V. (2021) · Canadian Journal of Animal Science · doi:10.1139/cjas-2020-0051 · Cited by 1
Fermentability of select polyphenol‐rich substrates in the canine faecal inoculum and their interaction with a canine‐origin probiotic: an in vitro appraisal
Ashwin, K., Pattanaik, A. K., Paladan, V., Singh, A., Sahoo, J. K., Jose, T., Jadhav, S. E., & Dutta, N. (2021) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.11495 · Cited by 1
Microbial and Protease Fermentation of Mao-Tai Lees Alters Nutritional Composition and Promotes In Vitro Intestinal Proteolysis
Yi, S., Azad, M. A. K., Ji, Y., Liu, Y., Dou, M., & Kong, X. (2022) · Agriculture · doi:10.3390/agriculture13010064 · Cited by 1
Mitochondria Inspire a LifestylePreprint
Krämer, P., & Bressan, P. (2018) · doi:10.31234/osf.io/t49eg · Cited by 2
Metabolism of the challenged intestinal epithelial cell
Bekebrede, A. F. (2023) · doi:10.18174/578215 · Cited by 1
Organoid based models to study the role of gut microbiota metabolites in post-weaning diarrhea
van der Hee, B. (2023) · doi:10.18174/630692 · Cited by 1
Activation mechanism of AhR pathway in intestinal epithelial cells by commensal bacteria
Marinelli, L. (2018) · theses.fr (ABES) · doi:10.70675/fcff0336z601cz4152z97f7z6e398d94c34b · Cited by 1
O papel da composição de ácidos graxos da dieta na lipectomia e nas doenças inflamatórias intestinais.
Coelho, D. (2013) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2013.tde-29052014-161540
Influence of High Dietary Zinc on Structure and Selected Functional Aspects of Intestinal Microbial Communities in Piglets
Starke, I. C. (2014) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-17464
Flux de protéines endogènes dans l'intestin et métabolisme postprandial des acides aminés alimentaires chez les mammifères monogastriques et chez l'homme
Deglaire, A. (2008) · HAL
Zebrafish as a novel animal model for evaluating the human gastrointestinal microbiota in autism spectrum disorder
Toh, M. C. W. (2015) · The Atrium (University of Guelph)
Diet and dysbiosis
Estaki, M., Quin, C., & Gibson, D. L. (2016) · Wiley eBooks · doi:10.1002/9781118982907.ch29
The Effect of Low Protein on Colonic Mucosal Barrier in Pigs
Hou, Q., Mi, X., Hu, W., Yu, Q., & Zhang, B. (2017) · International Journal of Morphology · doi:10.4067/s0717-95022017000300013
Effects of probiotic Lactobacillus pentosus S-PT84 and prebiotic isomaltodexrin on microbiota population in low-grade chronic inflammation in C57BL/6 mouse model
Zong, L. (2017) · The Atrium (University of Guelph)

Authors: Blachier, F., Mariotti, F., Huneau, J. F., & Tomé, D.
Affiliations: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
Physiologie de la Nutrition et du Comportement Alimentaire (FR)
ORCID: Blachier, F.
Mariotti, F.
Huneau, J. F.
Tomé, D.
Venue: Amino Acids
Publisher: Springer Science and Business Media LLC
Published: 2006-12-06
Volume: 33
Issue: 4
Pages: 547-562
ISSN: 0939-4451 (ISSN-L)
1438-2199
DOI: 10.1007/s00726-006-0477-9
OpenAlex: W1975034176
Semantic Scholar: 378e65004ac0b84d7d32fddc40404dfde955ba9e
Cited by: 452
References: 274
Citations by year: 2026: 19 · 2025: 25 · 2024: 43 · 2023: 35 · 2022: 41 · 2021: 34 · 2020: 32 · 2019: 36 · 2018: 36 · 2017: 21 · 2016: 18 · 2015: 27 · 2014: 11 · 2013: 12 · 2012: 17
FWCI: 0.48
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Amino Acids (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
Keywords: colonic epithelium, colonic microbiota, ammonia, hydrogen sulfide, short-chain fatty acids, branched-chain fatty acids, amines, phenolic compounds, N-nitroso compounds, colonic stasis, oxidative metabolism, electrolyte transport, colonic homeostasis, colon carcinogenesis
MeSH terms: Amino Acids, Ammonia, Animals, Bacteria, Colon, Colonic Diseases, Dietary Proteins, Digestion, Epithelial Cells, Fatty Acids, Humans, Hydrogen Sulfide, Intestinal Mucosa, Intestine, Large, Nitroso Compounds, Polyamines, Hydroxybenzoates

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks