Cited by 452Gut microbiota and healthAnimal Nutrition and PhysiologyPolyamine Metabolism and Applications

The DOI matches its Crossref record; 273 of the 274 references it cites were found in a registry or an index.

Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences

Blachier, F., Mariotti, F., Huneau, J. F., Tomé, D.·2007·Amino Acids

Open this paper in CoChat — free account

Abstract

Depending on the amount of alimentary proteins, between 6 and 18 g nitrogenous material per day enter the large intestine lumen through the ileocaecal junction. This material is used as substrates by the flora resulting eventually in the presence of a complex mixture of metabolites including ammonia, hydrogen sulfide, short and branched-chain fatty acids, amines; phenolic, indolic and N-nitroso compounds. The beneficial versus deleterious effects of these compounds on the colonic epithelium depend on parameters such as their luminal concentrations, the duration of the colonic stasis, the detoxication capacity of epithelial cells in response to increase of metabolite concentrations, the cellular metabolic utilization of these metabolites as well as their effects on colonocyte intermediary and oxidative metabolism. Furthermore, the effects of metabolites on electrolyte movements through the colonic epithelium must as well be taken into consideration for such an evaluation. The situation is further complicated by the fact that other non-nitrogenous compounds are believed to interfere with these various phenomenons. Finally, the pathological consequences of the presence of excessive concentrations of these compounds are related to the short- and, most important, long-term effects of these compounds on the rapid colonic epithelium renewing and homeostasis.

Integrity signals

Registry

Crossref · 10.1007/s00726-006-0477-9

Cites

273 of 273 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513
Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and Finland
Lichtenstein, P., Holm, N. V., Verkasalo, P. K., Iliadou, A., Kaprio, J., Koskenvuo, M., Pukkala, E., Skytthe, A., & Hemminki, K. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007133430201 · Cited by 4,114
Polyamine metabolism and function
Pegg, A. E., & McCann, P. P. (1982) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1982.243.5.c212 · Cited by 1,661
Utilization of Nutrients by Isolated Epithelial Cells of the Rat Colon
Roediger, W. E. W. (1982) · Gastroenterology · doi:10.1016/s0016-5085(82)80339-9 · Cited by 1,187
Toxicology Of Hydrogen Sulfide
Reiffenstein, R. J., Hulbert, W. C., & Roth, S. (1992) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.32.040192.000545 · Cited by 971
Balancing Life-Style and Genomics Research for Disease Prevention
Willett, W. C. (2002) · Science · doi:10.1126/science.1071055 · Cited by 888
Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications
Thomas, T., & Thomas, T. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000852 · Cited by 862
The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP
Ricquier, D., & Bouillaud, F. (2000) · Biochemical Journal · doi:10.1042/bj3450161 · Cited by 811
Effects of short chain fatty acids on gut morphology and function
Scheppach, W. (1994) · Gut · doi:10.1136/gut.35.1_suppl.s35 · Cited by 756
THE COLONIC EPITHELIUM IN ULCERATIVE COLITIS: AN ENERGY-DEFICIENCY DISEASE?
Roediger, W. E. W. (1980) · The Lancet · doi:10.1016/s0140-6736(80)91934-0 · Cited by 728

Flagged first, then by citations

Show all 274 references

1 of the 274 references couldn’t be matched to a known paper.

Research works printed but not linked: 35

SK Clinton, 1988, Cancer Res, 48, 3035
JD Cremin, 2003, Am J Physiol, 285, G105
AJ Cross, 2003, Cancer Res, 63, 2358
B Darcy-Vrillon, 1993, J Nutr, 123, 234
B Duranton, 1997, Cancer Res, 57, 573
P Evenepoel, 1999, Am J Physiol, 277, G935
J Fioramonti, 1994, Am J Physiol, 267, G960
DD Ginty, 1989, Am J Physiol, 257, G145
E Giovanucci, 1994, Cancer Res, 54, 2930
RA Goldhom, 1994, Cancer Res, 54, 718
ME Handlogten, 2005, Am J Physiol, 288, G1036
BG Heerdt, 1994, Cancer Res, 54, 3288
CM Hogaboam, 1995, Am J Physiol, 268, G673
R Hughes, 2000, Curr Issues Intest Microbiol, 1, 51
H Inoue, 2005, Am J Physiol, 289, F451
J Jorgensen, 2001b, Am J Physiol, 281, G405
P Kubes, 1992, Am J Physiol, 262, G1138
P Kubes, 1993, Am J Physiol, 264, G143
L Lee, 1981, Cancer Res, 41, 3992
JL Lyon, 1987, J Natl Cancer Inst, 78, 853
GT Macfarlane, 1986, J Gen Microbiol, 132, 1647
GT Macfarlane, 1992, J Appl Bacteriol, 72, 57
S Mc Cormack, 1991, Am J Physiol, 260, G795
B Mouillé, 2004, Am J Physiol, 287, G344
MW Musch, 2001, Am J Physiol, 280, G687
M Niiyama, 1979, Am J Vet Res, 40, 716
I Noordgaard, 1995, Nutrition, 11, 129
DL Osborne, 1990, Am J Physiol, 21, G576
BC Radcliffe, 1987, Am J Physiol, 253, G246
T Sobko, 2004, Am J Physiol, 287, G993
F Suarez, 1998, Am J Physiol, 274, G727
S Ugawa, 2001, Am J Physiol, 281, G365
T Witthöf, 1998, Am J Physiol, 275, G564
O Wrong, 1965, Clin Sci, 28, 357
A Zimber, 1972, Am J Clin Nutr, 223, 1004

Sorted by citations

Items 101–200 of 450

Effects of short-chain fructooligosaccharides and galactooligosaccharides, individually and in combination, on nutrient digestibility, fecal fermentative metabolite concentrations, and large bowel microbial ecology of healthy adults cats
Kanakupt, K., Boler, B. M. V., Dunsford, B. R., & Fahey, G. C., Jr. (2011) · Journal of Animal Science · doi:10.2527/jas.2010-3201 · Cited by 86
The effect of ageing with and without non-steroidal anti-inflammatory drugs on gastrointestinal microbiology and immunology
Tiihonen, K., Tynkkynen, S., Ouwehand, A. C., Ahlroos, T., & Rautonen, N. (2008) · British Journal Of Nutrition · doi:10.1017/s000711450888871x · Cited by 87
Dietary supplementation with chitooligosaccharides alters gut microbiota and modifies intestinal luminal metabolites in weaned Huanjiang mini-piglets
Kong, X., Zhou, X. L., Lian, G., Blachier, F., Liu, G., Tan, B., Nyachoti, C. M., & Yin, Y. (2013) · Livestock Science · doi:10.1016/j.livsci.2013.11.023 · Cited by 86
Self-citation
Pilot Dietary Intervention with Heat-Stabilized Rice Bran Modulates Stool Microbiota and Metabolites in Healthy Adults
Sheflin, A. M., Borresen, E. C., Wdowik, M. J., Rao, S., Brown, R. J., Heuberger, A. L., Broeckling, C. D., Weir, T. L., & Ryan, E. P. (2015) · Nutrients · doi:10.3390/nu7021282 · Cited by 89
Fatty acids produced by the gut microbiota dampen host inflammatory responses by modulating intestinal SUMOylation
Ezzine, C., Loison, L., Montbrion, N., Bôle‐Feysot, C., Déchelotte, P., Coëffier, M., & Ribet, D. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2108280 · Cited by 83
Effects of dietary l-lysine intake on the intestinal mucosa and expression of CAT genes in weaned piglets
He, L., Yang, H., Hou, Y., Li, T., Fang, J. Q., Zhou, X., Yin, Y., Wu, L., Nyachoti, C. M., & Wu, G. (2013) · Amino Acids · doi:10.1007/s00726-013-1514-0 · Cited by 83
Channelling of arginine in NO and polyamine pathways in colonocytes and consequences
Blachier, F. (2010) · Frontiers in bioscience · doi:10.2741/3792 · Cited by 81
Self-citation
Soluble xyloglucan generates bigger bacterial community shifts than pectic polymers during in vitro fecal fermentation
Cantu-Jungles, T. M., do Nascimento, G. E., Zhang, X., Iacomini, M., Cordeiro, L. M. C., & Hamaker, B. R. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.11.011 · Cited by 81
The Effect of Amino Acids on Production of SCFA and bCFA by Members of the Porcine Colonic Microbiota
den Abbeele, P. V., Ghyselinck, J., Marzorati, M., Koch, A.-M., Lambert, W., Michiels, J., & Chalvon‐Demersay, T. (2022) · Microorganisms · doi:10.3390/microorganisms10040762 · Cited by 84
Colonic luminal microbiota and bacterial metabolite composition in pregnant Huanjiang mini-pigs: effects of food composition at different times of pregnancy
Kong, X., Ji, Y., Li, H., Zhu, Q., Blachier, F., Geng, M., Chen, W., & Yin, Y. (2016) · Scientific Reports · doi:10.1038/srep37224 · Cited by 77
Self-citation
Perspective on Recent Developments on Sulfur-Containing Agents and Hydrogen Sulfide Signaling
Jacob, C., Anwar, A., & Burkholz, T. (2008) · Planta Medica · doi:10.1055/s-0028-1088299 · Cited by 78
Caecal fermentation, putrefaction and microbiotas in rats fed milk casein, soy protein or fish meal
An, C., Kuda, T., Yazaki, T., Takahashi, H., & Kimura, B. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-5271-5 · Cited by 80
Ileal and faecal protein digestibility measurement in humans and other non-ruminants – a comparative species view
Hendriks, W. H., van Baal, J., & Bosch, G. (2012) · British Journal of Nutrition · doi:10.1017/s0007114512002395 · Cited by 76
Effects of polysaccharide from Pueraria lobata on gut microbiota in mice
Chen, R., Liu, B., Wang, X., Chen, K., Zhang, K., Zhang, L., Fei, C., Wang, C., Liu, Y., Xue, F., et al. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.04.201 · Cited by 77
Dietary supplementation with soybean oligosaccharides increases short-chain fatty acids but decreases protein-derived catabolites in the intestinal luminal content of weaned Huanjiang mini-piglets
Zhou, X., Kong, X., Lian, G., Blachier, F., Geng, M., & Yin, Y. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.08.008 · Cited by 75
Self-citation
The Potential Role of the Dipeptidyl Peptidase-4-Like Activity From the Gut Microbiota on the Host Health
Olivares, M., Schüppel, V., Hassan, A. M., Beaumont, M., Neyrinck, A. M., Bindels, L. B., Benítez-Páez, A., Sanz, Y., Haller, D., Holzer, P., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01900 · Cited by 72
An integrated look at the effect of structure on nutrient bioavailability in plant foods
Capuano, E., & Pellegrini, N. (2018) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.9298 · Cited by 76
Influence of dietary protein and fructooligosaccharides on fecal fermentative end-products, fecal bacterial populations and apparent total tract digestibility in dogs
Pinna, C., Vecchiato, C. G., Bolduan, C., Grandi, M., Stefanelli, C., Windisch, W. M., Zaghini, G., & Biagi, G. (2018) · BMC Veterinary Research · doi:10.1186/s12917-018-1436-x · Cited by 74
Haem iron reshapes colonic luminal environment: impact on mucosal homeostasis and microbiome through aldehyde formation
Martin, O. C. B., Olier, M., Ellero‐Simatos, S., Naud, N., Dupuy, J., Laurence Therese, H. U. C., Taché, S., Graillot, V., Levêque, M., Bézirard, V., et al. (2019) · Microbiome · doi:10.1186/s40168-019-0685-7 · Cited by 73
Self-citation
Digesting the complex metabolic effects of diet on the host and microbiome
Carmody, R. N., Varady, K. A., & Turnbaugh, P. J. (2024) · Cell · doi:10.1016/j.cell.2024.06.032 · Cited by 76
Modulation of Protein Fermentation Does Not Affect Fecal Water Toxicity: A Randomized Cross-Over Study in Healthy Subjects
Windey, K., Preter, V. D., Louat, T., Schuit, F. C., Herman, J., Vansant, G. A. A. M., & Verbeke, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052387 · Cited by 79
Casein glycomacropeptide in the diet may reduceEscherichia coliattachment to the intestinal mucosa and increase the intestinal lactobacilli of early weaned piglets after an enterotoxigenicE. coliK88 challenge
Hermes, R. G., Molist, F., Pérez, J. F., de Segura, A. G., Ywazaki, M., Davin, R., Nofrarías, M., Korhonen, T., Virkola, R., & Martín-Orúe, S. M. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512002978 · Cited by 71
Marked Response in Microbial Community and Metabolism in the Ileum and Cecum of Suckling Piglets After Early Antibiotics Exposure
Yu, M., Mu, C., Zhang, C., Yang, Y., Su, Y., & Zhu, W. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01166 · Cited by 76
Metabolomics approaches for characterizing metabolic interactions between host and its commensal microbes
Xie, G., Zhang, S., Zheng, X., & Jia, W. P. (2013) · Electrophoresis · doi:10.1002/elps.201300017 · Cited by 71
Dietary flaxseed modulates the colonic microenvironment in healthy C57Bl/6 male mice which may alter susceptibility to gut-associated diseases
Power, K. A., Lepp, D., Zarepoor, L., Monk, J. M., Wu, W., Tsao, R., & Liu, R. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.09.028 · Cited by 70
Butyrate metabolism in human colon carcinoma cells: Implications concerning its growth‐inhibitory effect
Andriamihaja, M., Chaumontet, C., Tomé, D., & Blachier, F. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21556 · Cited by 69
Self-citation
Therapeutic applications of organosulfur compounds as novel hydrogen sulfide donors and/or mediators
Gu, X., & Zhu, Y. Z. (2010) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.10.129 · Cited by 68
Alterations in fecal short chain fatty acids (SCFAs) and branched short-chain fatty acids (BCFAs) in men with benign prostatic hyperplasia (BPH) and metabolic syndrome (MetS)
Ratajczak, W., Mizerski, A., Rył, A., Słojewski, M., Sipak‐Szmigiel, O., Piasecka, M., & Laszczyńska, M. (2021) · Aging · doi:10.18632/aging.202968 · Cited by 70
The Role of Probiotics and Their Metabolites in the Treatment of Depression
Jach, M. E., Serefko, A., Szopa, A., Sajnaga, E., Golczyk, H., Santos, L. S., Borowicz, K. K., & Sieniawska, E. (2023) · Molecules · doi:10.3390/molecules28073213 · Cited by 75
Influence of dietary protein content and source on colonic fermentative activity in dogs differing in body size and digestive tolerance1
Nery, J., Goudez, R., Biourge, V. C., Tournier, C., Leray, V., Martin, L., Thorin, C., Nguyen, P., & Dumon, H. (2012) · Journal of Animal Science · doi:10.2527/jas.2011-4112 · Cited by 66
Gut Metabolites Acting on the Gut-Brain Axis: Regulating the Functional State of Microglia
Deng, W., Yi, P., Xiong, Y., Ying, J., Lin, Y., Dong, Y., Wei, G., Wang, X., & Hua, F. (2023) · Aging and Disease · doi:10.14336/ad.2023.0727 · Cited by 70
Differential effect of early antibiotic intervention on bacterial fermentation patterns and mucosal gene expression in the colon of pigs under diets with different protein levels
Zhang, C., Yu, M., Yang, Y., Mu, C., Su, Y., & Zhu, W. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7985-7 · Cited by 64
Amino acid metabolism in the portal-drained viscera of young pigs: effects of dietary supplementation with chitosan and pea hull
Yin, Y., Huang, R., Li, T., Ruan, Z., Xie, M., Deng, Z., Hou, Y., & Wu, G. (2010) · Amino Acids · doi:10.1007/s00726-010-0577-4 · Cited by 63
Effects of macro-nutrient, micro-nutrient composition and cooking conditions on in vitro digestibility of meat and aquatic dietary proteins
Luo, J., Taylor, C., Nebl, T., Ng, K., & Bennett, L. E. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2018.01.164 · Cited by 63
The Role of Bacteriophages in the Gut Microbiota: Implications for Human Health
Emencheta, S. C., Olovo, C. V., Eze, O. C., Kalu, C. F., BEREBON, D. P., Onuigbo, E. B., Vila, M. M. D. C., Balcão, V. M., & Attama, A. A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15102416 · Cited by 68
Dietary Protein Excess during Neonatal Life Alters Colonic Microbiota and Mucosal Response to Inflammatory Mediators Later in Life in Female Pigs
Boudry, G., Jamin, A., Chatelais, L., Guen, C. G., Michel, C., & Huërou‐Luron, I. L. (2013) · Journal of Nutrition · doi:10.3945/jn.113.175828 · Cited by 61
Dietary xylo-oligosaccharide supplementation alters gut microbial composition and activity in pigs according to age and dose
Pan, J., Yin, J., Zhang, K., Xie, P., Ding, H., Huang, X., Blachier, F., & Kong, X. (2019) · AMB Express · doi:10.1186/s13568-019-0858-6 · Cited by 65
Self-citation
Gastrointestinal interaction between dietary amino acids and gut microbiota: with special emphasis on host nutrition
Abdallah, A., Elemba, E., Zhong, Q., & Sun, Z. (2020) · Current Protein & Peptide Science · doi:10.2174/1389203721666200212095503 · Cited by 59
Regulation of Gastrointestinal Immunity by Metabolites
Gu, B., Kim, M., & Yun, C. (2021) · Nutrients · doi:10.3390/nu13010167 · Cited by 57
High-protein diet differently modifies intestinal goblet cell characteristics and mucosal cytokine expression in ileum and colon
Lan, A., Andriamihaja, M., Blouin, J.-M., Liu, X., Descatoire, V., Desclée de Maredsous, C., Davila, A.-M., Walker, F., Tomé, D., & Blachier, F. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.09.007 · Cited by 57
Effect of dietary fiber fermentation on short‐chain fatty acid production and microbial composition in vitro
Bai, Y., Zhao, J., Tao, S., Zhou, X., Pi, Y., Gerrits, W. J. J., Johnston, L. J., Zhang, S., Yang, H., Liu, L., et al. (2020) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10470 · Cited by 57
Role of Heme Iron in the Association Between Red Meat Consumption and Colorectal Cancer
Sasso, A., & Latella, G. (2018) · Nutrition and Cancer · doi:10.1080/01635581.2018.1521441 · Cited by 56
Colonic luminal ammonia and portal blood l-glutamine and l-arginine concentrations: a possible link between colon mucosa and liver ureagenesis
Eklou-Lawson, M., Bernard, F., Neveux, N., Chaumontet, C., Bos, C., Davila, A., Tomé, D., Cynober, L., & Blachier, F. (2008) · Amino Acids · doi:10.1007/s00726-008-0218-3 · Cited by 55
Self-citation
Fecal Microbiota and Metabolome in a Mouse Model of Spontaneous Chronic Colitis
Robinson, A. M., Gondalia, S. V., Karpe, A. V., Eri, R. D., Beale, D. J., Morrison, P. D., Palombo, E. A., & Nurgali, K. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000970 · Cited by 55
Low Protein-High Carbohydrate Diets Alter Energy Balance, Gut Microbiota Composition and Blood Metabolomics Profile in Young Pigs
Spring, S., Premathilake, H., DeSilva, U., Shili, C. N., Carter, S., & Pezeshki, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-60150-y · Cited by 55
Effects of a diet high in resistant starch on fermentation end‐products of protein and mucin secretion in the colons of pigs
Zhou, L., Fang, L., Sun, Y., Su, Y., & Zhu, W. (2016) · Starch - Stärke · doi:10.1002/star.201600032 · Cited by 54
Nutrition and health relevant regulation of intestinal sulfur amino acid metabolism
Fang, Z., Yao, K., Zhang, X., Zhao, S., Sun, Z., Tian, G., Yu, B., Lin, Y., Zhu, B., Jia, G., et al. (2010) · Amino Acids · doi:10.1007/s00726-010-0502-x · Cited by 54
Navy Beans Impact the Stool Metabolome and Metabolic Pathways for Colon Health in Cancer Survivors
Baxter, B. A., Oppel, R. C., & Ryan, E. P. (2018) · Nutrients · doi:10.3390/nu11010028 · Cited by 57
Levels of Rectal Mucosal Polyamines and Prostaglandin E2 Predict Ability of DFMO and Sulindac to Prevent Colorectal Adenoma
Thompson, P. A., Wertheim, B. C., Zell, J. A., Chen, W., McLaren, C. E., LaFleur, B., Meyskens, F. L., & Gerner, E. W. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.06.005 · Cited by 51
Metabolomics: Towards Understanding Host–Microbe Interactions
Han, J., Antunes, L. C. M., Finlay, B. B., & Borchers, C. H. (2010) · Future Microbiology · doi:10.2217/fmb.09.132 · Cited by 51
Gut Microbiota of Nonalcoholic Fatty Liver Disease
Abdou, R., Zhu, L., Baker, R. D., & Baker, S. S. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4045-1 · Cited by 52
Effect of Lactobacillus plantarum-fermented mulberry pomace on antioxidant properties and fecal microbial community
Tang, S., Cheng, Y., Wu, T., Hu, F., Pan, S., & Xu, X. (2021) · LWT · doi:10.1016/j.lwt.2021.111651 · Cited by 51
Changes of Mouse Gut Microbiota Diversity and Composition by Modulating Dietary Protein and Carbohydrate Contents: A Pilot Study
Kim, E., Kim, D., & Park, J.-Y. (2016) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2016.21.1.57 · Cited by 52
Animal Models for the Study of the Relationships between Diet and Obesity: A Focus on Dietary Protein and Estrogen Deficiency
Chalvon‐Demersay, T., Blachier, F., Tomé, D., & Blais, A. (2017) · Frontiers in Nutrition · doi:10.3389/fnut.2017.00005 · Cited by 50
Self-citation
Microbiome-Metabolomics Analysis Investigating the Impacts of Dietary Starch Types on the Composition and Metabolism of Colonic Microbiota in Finishing Pigs
Yu, M., Li, Z., Chen, W., Rong, T. Z., Wang, G., & Ma, X. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01143 · Cited by 49
Effects of the l-tyrosine-derived bacterial metabolite p-cresol on colonic and peripheral cells
Blachier, F., & Andriamihaja, M. (2021) · Amino Acids · doi:10.1007/s00726-021-03064-x · Cited by 53
Self-citation
Antibiotic-induced alterations of the gut microbiota and microbial fermentation in protein parallel the changes in host nitrogen metabolism of growing pigs
Pi, Y., Gao, K., Peng, Y., Mu, C., & Zhu, W. (2018) · animal · doi:10.1017/s1751731118001416 · Cited by 53
Chemical Metabolism of Xenobiotics by Gut Microbiota
Nakov, R., & Velikova, T. V. (2020) · Current Drug Metabolism · doi:10.2174/1389200221666200303113830 · Cited by 52
Dietary protein levels and amino acid supplementation patterns alter the composition and functions of colonic microbiota in pigs
Zhao, Y., Tian, G., Chen, D., Zheng, P., Yu, J., He, J., Mao, X., Huang, Z., Luo, Y., Luo, J., et al. (2020) · Animal nutrition · doi:10.1016/j.aninu.2020.02.005 · Cited by 48
Pectic polysaccharides from Aconitum carmichaelii leaves protects against DSS-induced ulcerative colitis in mice through modulations of metabolism and microbiota composition
Fu, Y., Li, C., Peng, X., Wangensteen, H., Inngjerdingen, K. T., & Zou, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113767 · Cited by 46
Mucosal Healing in Inflammatory Bowel Diseases
Lan, A., Blachier, F., Benamouzig, R., Beaumont, M., Barrat, C., Coelho, D., Lancha, A. H., Kong, X., Yin, Y., Marie, J., et al. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000177 · Cited by 49
Self-citation
Considerations for the design and conduct of human gut microbiota intervention studies relating to foods
Swann, J. R., Rajilić-Stojanović, M. D., Salonen, A., Sakwińska, O., Gill, C. M., Meynier, A., Fança‐Berthon, P., Schelkle, B., Segata, N., Shortt, C., et al. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02232-1 · Cited by 48
Protein combined with certain dietary fibers increases butyrate production in gut microbiota fermentation
Jackson, R., Yao, T., Bulut, N., Cantu-Jungles, T. M., & Hamaker, B. R. (2024) · Food & Function · doi:10.1039/d3fo04187e · Cited by 51
In Vitro Fermentation Characteristics of Select Nondigestible Oligosaccharides by Infant Fecal Inocula
Boler, B. M. V., Serao, M. C. R., Faber, T. A., Bauer, L. L., Chow, J., Murphy, M. R., & Fahey, G. C., Jr. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf305056f · Cited by 45
Impact of Kamut® Khorasan on gut microbiota and metabolome in healthy volunteers
Saa, D. L. T., Turroni, S., Serrazanetti, D. I., Rampelli, S., Maccaferri, S., Candela, M., Severgnini, M., Simonetti, E., Brigidi, P., & Gianotti, A. (2014) · Food Research International · doi:10.1016/j.foodres.2014.04.005 · Cited by 43
Preventive oral supplementation with glutamine and arginine has beneficial effects on the intestinal mucosa and inflammatory cytokines in endotoxemic rats
Zhou, X., Wu, X., Yin, Y., Zhang, C., & He, L. (2011) · Amino Acids · doi:10.1007/s00726-011-1137-2 · Cited by 43
The effect of benzoic acid concentration on nitrogen metabolism, manure ammonia and odour emissions in finishing pigs
Murphy, D., O’Doherty, J. V., Boland, T. M., O’Shea, C. J., Callan, J. J., Pierce, K. M., & Lynch, M. B. (2010) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2010.10.009 · Cited by 42
Effects of low dietary protein on the metabolites and microbial communities in the caecal digesta of piglets
Luo, Z., Li, C., Cheng, Y., Hang, S., & Zhu, W. (2015) · Archives of Animal Nutrition · doi:10.1080/1745039x.2015.1034521 · Cited by 42
Compared with Raw Bovine Meat, Boiling but Not Grilling, Barbecuing, or Roasting Decreases Protein Digestibility without Any Major Consequences for Intestinal Mucosa in Rats, although the Daily Ingestion of Bovine Meat Induces Histologic Modifications in the Colon
Oberli, M., Lan, A., Khodorova, N., Santé-Lhoutellier, V., Walker, F., Piedcoq, J., Davila, A., Blachier, F., Tomé, D., Fromentin, G., et al. (2016) · Journal of Nutrition · doi:10.3945/jn.116.230839 · Cited by 41
Self-citation
Dietary proline supplementation alters colonic luminal microbiota and bacterial metabolite composition between days 45 and 70 of pregnancy in Huanjiang mini-pigs
Ji, Y., Guo, Q., Yin, Y., Blachier, F., & Kong, X. (2018) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-018-0233-5 · Cited by 41
Self-citation
Microbiome response to diet: focus on obesity and related diseases
Delzenne, N. M., Rodriguez, J., Olivares, M., & Neyrinck, A. M. (2020) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09572-7 · Cited by 40
Protein and amino acids
Mai, K., Xue, M., He, G., Xie, S., & Kaushik, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819587-1.00012-4 · Cited by 39
Determination of Biogenic Amines in Digesta by High Performance Liquid Chromatography with Precolumn Dansylation
Yang, Y., Mu, C., Zhang, J., & Zhu, W. (2014) · Analytical Letters · doi:10.1080/00032719.2013.871550 · Cited by 39
Exploiting the interactions between plant proteins and gut microbiota to promote intestinal health
Jia, J., Dell’Olio, A., Izquierdo-Sandoval, D., Capuano, E., Liu, X., Duan, X., & Rubert, J. (2024) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2024.104749 · Cited by 41
Metabolite quantification of faecal extracts from colorectal cancer patients and healthy controls
Gall, G. L., Guttula, K., Kellingray, L., Tett, A., ten Hoopen, R., Kemsley, E. K., Savva, G. M., Ibrahim, A. E. K., & Narbad, A. (2018) · Oncotarget · doi:10.18632/oncotarget.26022 · Cited by 39
Specific Microbiota Dynamically Regulate the Bidirectional Gut–Brain Axis Communications in Mice Fed Meat Protein Diets
Xie, Y., Zhou, G., Wang, C., Xu, X., & Li, C. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b05654 · Cited by 37
Effect of feeding a selected combination of galacto-oligosaccharides and a strain of Bifidobacterium pseudocatenulatum on the intestinal microbiota of cats
Biagi, G., Cipollini, I., Bonaldo, A., Grandi, M., Pompei, A., Stefanelli, C., & Zaghini, G. (2012) · American Journal of Veterinary Research · doi:10.2460/ajvr.74.1.90 · Cited by 36
Indices of gastrointestinal fermentation and manure emissions of growing-finishing pigs as influenced through singular or combined consumption of Lactobacillus plantarum and inulin
O’Shea, C. J., Sweeney, T., Bahar, B., Ryan, M. T., Thornton, K. H., & O’Doherty, J. V. (2012) · Journal of Animal Science · doi:10.2527/jas.2011-4461 · Cited by 36
Progressive response of large intestinal bacterial community and fermentation to the stepwise decrease of dietary crude protein level in growing pigs
Peng, Y., Yu, K., Mu, C., Hang, S., Che, L., & Zhu, W. (2017) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-017-8285-6 · Cited by 36
Effect of a proanthocyanidin-rich polyphenol extract from avocado on the production of amino acid-derived bacterial metabolites and the microbiota composition in rats fed a high-protein diet
Cires, M. J., Navarrete, P., Pastene, E., Carrasco‐Pozo, C., Valenzuela, R., Medina, D. A., Andriamihaja, M., Beaumont, M., Blachier, F., & Gotteland, M. (2019) · Food & Function · doi:10.1039/c9fo00700h · Cited by 36
Self-citation
Maternal microbiota and gestational diabetes: impact on infant health
Singh, P., Elhag, D. A., Ibrahim, I., Abdullahi, H., & Khodor, S. A. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04230-3 · Cited by 41
Fate of undigested proteins in the pig large intestine: What impact on the colon epithelium?
Blachier, F., Andriamihaja, M., & Kong, X. (2021) · Animal nutrition · doi:10.1016/j.aninu.2021.08.001 · Cited by 35
Self-citation
Flavonoid extract of saffron by‐product alleviates hyperuricemia via inhibiting xanthine oxidase and modulating gut microbiota
Chen, N., Wang, R., Li, H., Wang, W., Wang, L., Yin, X., Yao, R., & Yang, B. (2022) · Phytotherapy Research · doi:10.1002/ptr.7579 · Cited by 36
Dietary supplementation with fermented Mao-tai lees beneficially affects gut microbiota structure and function in pigs
Li, H., Li, H., Xie, P., Li, Z., Yin, Y., Blachier, F., & Kong, X. (2019) · AMB Express · doi:10.1186/s13568-019-0747-z · Cited by 34
Self-citation
Enhancing Metabolism and Milk Production Performance in Periparturient Dairy Cattle through Rumen-Protected Methionine and Choline Supplementation
Huang, B., Khan, M. Z., Kou, X., Chen, Y., Liang, H., Ullah, Q., Khan, N., Khan, A. A., Chai, W., & Wang, C. (2023) · Metabolites · doi:10.3390/metabo13101080 · Cited by 34
The role of gut microbiota in human metabolism and inflammatory diseases: a focus on elderly individuals
Khaledi, M., Poureslamfar, B., Alsaab, H. O., Tafaghodi, S., Hjazi, A. M., Singh, R., Alawadi, A. H., Alsaalamy, A. H., Qasim, Q. A., & Sameni, F. (2024) · Annals of Microbiology · doi:10.1186/s13213-023-01744-5 · Cited by 50
Type, Intensity, and Duration of Exercise as Regulator of Gut Microbiome Profile
Suryani, D., Alfaqih, M. S., Gunadi, J. W., Sylviana, N., Goenawan, H., Megantara, I., & Lesmana, R. (2022) · Current Sports Medicine Reports · doi:10.1249/jsr.0000000000000940 · Cited by 34
Challenges and opportunities for improving nitrogen utilization efficiency for more sustainable pork production
Shurson, G. C., & Kerr, B. J. (2023) · Frontiers in Animal Science · doi:10.3389/fanim.2023.1204863 · Cited by 39
Effects of dietary nutrient levels on microbial community composition and diversity in the ileal contents of pregnant Huanjiang mini-pigs
Ji, Y., Kong, X., Li, H., Zhu, Q., Guo, Q., & Yin, Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172086 · Cited by 32
A Review on Autism Spectrum Disorder: Pathogenesis, Biomarkers, Pharmacological and Non-Pharmacological Interventions
Majhi, S., Kumar, S., & Singh, L. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220428134802 · Cited by 33
Effects of Dietary Different Doses of Copper and High Fructose Feeding on Rat Fecal Metabolome
Wei, X., Song, M., Yin, X., Schuschke, D. A., Koo, I., McClain, C. J., & Zhang, X. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00596 · Cited by 33
Dietary fibre and crude protein: impact on gastrointestinal microbial fermentation characteristics and host response
Pieper, R., Vahjen, W., & Zentek, J. (2015) · Animal Production Science · doi:10.1071/an15278 · Cited by 33
Dual effects of the tryptophan-derived bacterial metabolite indole on colonic epithelial cell metabolism and physiology: comparison with its co-metabolite indoxyl sulfate
Armand, L., Fofana, M., Couturier-Becavin, K., Andriamihaja, M., & Blachier, F. (2022) · Amino Acids · doi:10.1007/s00726-021-03122-4 · Cited by 33
Self-citation
Methionine-driven methylation modification overcomes plasmid-mediated high-level tigecycline resistance
Fang, D., Xu, T., Li, F., Sun, Y., Sun, J., Yin, Y., Zhang, H., Wang, Z., & Liu, Y. (2025) · Nature Communications · doi:10.1038/s41467-024-55791-w · Cited by 33
Dietary Supplementation With Chinese Herbal Residues or Their Fermented Products Modifies the Colonic Microbiota, Bacterial Metabolites, and Expression of Genes Related to Colon Barrier Function in Weaned Piglets
Su, J., Zhu, Q., Zhao, Y., Han, L., Yin, Y., Blachier, F., Wang, Z., & Kong, X. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03181 · Cited by 30
Self-citation
Microbial Fermentation Patterns, Diarrhea Incidence, and Performance in Weaned Piglets Fed a Low Protein Diet Supplemented with Probiotics
García, K. E., de Souza, T. C. R., Landín, G. M., Barreyro, A. A., Santos, M. G. B., & Soto, J. G. G. (2014) · Food and Nutrition Sciences · doi:10.4236/fns.2014.518191 · Cited by 30
Interactive effects of protein and carbohydrates on production of microbial metabolites in the large intestine of growing pigs
Taciak, M., Barszcz, M., Święch, E., Tuśnio, A., & Bachanek, I. (2017) · Archives of Animal Nutrition · doi:10.1080/1745039x.2017.1291202 · Cited by 30
Interactive Effects of Indigestible Carbohydrates, Protein Type, and Protein Level on Biomarkers of Large Intestine Health in Rats
Taciak, M., Barszcz, M., Tuśnio, A., & Pastuszewska, B. (2015) · PLOS ONE · doi:10.1371/journal.pone.0142176 · Cited by 29
Microbiome Therapeutics for Food Allergy
Chernikova, D. A., Zhao, M. Y., & Jacobs, J. P. (2022) · Nutrients · doi:10.3390/nu14235155 · Cited by 30
Effects of three major protein sources on performance, gut morphology and fermentation characteristics in broilers
Qaisrani, S. N., van Krimpen, M. M., Verstegen, M. W. A., Hendriks, W. H., & Kwakkel, R. P. (2019) · British Poultry Science · doi:10.1080/00071668.2019.1671958 · Cited by 29

Authors: Blachier, F., Mariotti, F., Huneau, J. F., & Tomé, D.
Affiliations: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
Physiologie de la Nutrition et du Comportement Alimentaire (FR)
ORCID: Blachier, F.
Mariotti, F.
Huneau, J. F.
Tomé, D.
Venue: Amino Acids
Publisher: Springer Science and Business Media LLC
Published: 2006-12-06
Volume: 33
Issue: 4
Pages: 547-562
ISSN: 0939-4451 (ISSN-L)
1438-2199
DOI: 10.1007/s00726-006-0477-9
OpenAlex: W1975034176
Semantic Scholar: 378e65004ac0b84d7d32fddc40404dfde955ba9e
Cited by: 452
References: 274
Citations by year: 2026: 19 · 2025: 25 · 2024: 43 · 2023: 35 · 2022: 41 · 2021: 34 · 2020: 32 · 2019: 36 · 2018: 36 · 2017: 21 · 2016: 18 · 2015: 27 · 2014: 11 · 2013: 12 · 2012: 17
FWCI: 0.48
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Amino Acids (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
Keywords: colonic epithelium, colonic microbiota, ammonia, hydrogen sulfide, short-chain fatty acids, branched-chain fatty acids, amines, phenolic compounds, N-nitroso compounds, colonic stasis, oxidative metabolism, electrolyte transport, colonic homeostasis, colon carcinogenesis
MeSH terms: Amino Acids, Ammonia, Animals, Bacteria, Colon, Colonic Diseases, Dietary Proteins, Digestion, Epithelial Cells, Fatty Acids, Humans, Hydrogen Sulfide, Intestinal Mucosa, Intestine, Large, Nitroso Compounds, Polyamines, Hydroxybenzoates

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks